Pentraxin 3 as a novel diagnostic marker in neonatal sepsis

Fahmey, Sameh Samir; Mostafa, Nadia M.

doi:10.3233/npm-190261

Cited by 16 publications

(16 citation statements)

References 23 publications

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“…Our result supported by Fahmey et al, 2020 6 revealed that Pulmonary systolic pressure was significantly higher in septic neonates compared to control group (p < .001)…”

Section: Discussionsupporting

confidence: 90%

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Assessment of Cardiac Functions in Neonatal Sepsis

Hassan

Hakeem

Abdelmotalep

et al. 2021

Al-Azhar International Medical Journal

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Background: One of the major organs influenced in neonatal sepsis is the heart. Echocardiogram gives real-time data on the cardiovascular execution instead of reliance on the clinical signs alone. Aim of the work: to study the role of transthoracic echocardiogram in the assessment of systolic and diastolic cardiac functions in septic neonates. Patients and methods: This cross sectional study was carried out on 80 neonate subdivided into 4 groups (septic full-term, septic preterm, nonseptic full-term and non-septic preterm) admitted to the tertiary care

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“…Our result supported by Fahmey et al, 2020 6 revealed that Pulmonary systolic pressure was significantly higher in septic neonates compared to control group (p < .001)…”

Section: Discussionsupporting

confidence: 90%

“…Our result were supported by Fahmey et al, 2020 6 as they stated that Septic neonates had a lower E/A ratio of the mitral valve when compared to healthy neonates (p, .048), indicating left ventricular diastolic dysfunction.…”

Section: Discussionsupporting

confidence: 87%

Assessment of Cardiac Functions in Neonatal Sepsis

Hassan

Hakeem

Abdelmotalep

et al. 2021

Al-Azhar International Medical Journal

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“…Its concentration increases rapidly in various infections and plays an important role in the early phase of inflammation. PTX-3 can be used as a prognostic biomarker in sepsis and septic shock in adults [36] and children [37]. PTX3 plasma levels are also increased in some non-infectious conditions that involve inflammation and endothelial damage, such as vascular atherosclerosis, inflammation or vascular damage [38][39][40][41], especially after myocardial infarction [42], reflecting the extent of tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Pentraxin 3 (PTX3): A Molecular Marker of Endothelial Dysfunction in Chronic Migraine

Domínguez-Vivero

Leira

López-Ferreiro

et al. 2020

JCM

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Even though endothelial dysfunction is known to play a role in migraine pathophysiology, studies regarding levels of endothelial biomarkers in migraine have controversial results. Our aim was to evaluate the role of pentraxin 3 (PTX3) and soluble tumour necrosis factor-like weak inducer of apoptosis (sTWEAK) as potential biomarkers of endothelial dysfunction in chronic migraine (CM). We performed a case-control study including 102 CM patients and 28 control subjects and measured serum levels of markers of endothelial dysfunction (PTX3 and sTWEAK) and inflammation [high-sensitivity C-reactive protein (hs-CRP)] as well as brachial artery flow-mediated dilation (FMD) during interictal periods. Interictal serum levels of PTX3 and sTWEAK were higher in CM patients than in controls (1350.6 ± 54.8 versus 476.1 ± 49.4 pg/mL, p < 0.001 and 255.7 ± 21.1 versus 26.4 ± 2.6 pg/mL, p < 0.0001; respectively). FMD was diminished in CM patients compared to controls (9.6 ± 0.6 versus 15.2 ± 0.9%, p < 0.001). Both PTX3 and sTWEAK were negatively correlated with FMD (r = −0.508, p < 0.001 and r = −0.188, p = 0.033; respectively). After adjustment of confounders, PTX3 remained significantly correlated to FMD (r = −0.250, p = 0.013). Diagnosis of CM was 68.4 times more likely in an individual with levels of PTX3 ≥ 832.5 pg/mL, suggesting that PTX3 could be a novel biomarker of endothelial dysfunction in CM.

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“…Elevated levels of PTX-3 have been found in septic shock ( 33 , 34 ), chronic kidney disease ( 35 ), stroke ( 36 ), and a variety of cardiovascular diseases ( 25 , 37 , 38 ). In younger populations, elevated levels of PTX-3 have been associated with neonatal sepsis ( 39 ), severe pediatric microbial infections ( 40 , 41 ), and autoimmune diseases, such as childhood-onset systemic lupus erythematosus ( 42 ), juvenile idiopathic arthritis ( 43 ), and asthma ( 44 ). In this study, we found significantly elevated circulating levels of PTX-3 in a cohort of patients with acute KD as compared to the PTX-3 levels in the same patients upon resolution of the disease, i.e., convalescent phase.…”

Section: Discussionmentioning

confidence: 99%

“…The positive repeated-measures correlation and Spearman's correlation in the acute phase between WBC, specifically neutrophils and PTX-3, suggest neutrophils as a possible source for PTX-3. Neutrophils have been shown to release PTX-3 when activated in cardiovascular disease and sepsis ( 33 , 34 , 39 ). Pathology studies of heart tissues from autopsies of children with KD has led to a model of KD vasculopathy that begins with an initial neutrophilic infiltration of the coronary artery, followed by infiltration of monocytes and macrophages, implicating these immune cells as key players in KD-associated CAL and vascular dysfunction ( 7 , 8 , 49 , 50 ).…”

Section: Discussionmentioning

confidence: 99%

Elevated Levels of Pentraxin 3 Correlate With Neutrophilia and Coronary Artery Dilation During Acute Kawasaki Disease

et al. 2020

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Kawasaki disease (KD) is the leading cause of acquired pediatric heart disease in the developed world as 25–30% of untreated patients and at least 5% of treated patients will develop irreversible coronary artery lesions (CAL). Pentraxin-3 (PTX-3) has been well-studied in inflammatory diseases, particularly in cardiovascular diseases associated with vascular endothelial dysfunction. We hypothesized that PTX-3 plays an important role in the development of KD-associated CAL and investigated the circulating levels of PTX-3 in the serum of KD patients. Children with acute KD were followed from diagnosis through normalization of the clinical parameters of inflammation (convalescent phase). Serum samples were obtained and echocardiograms were conducted at several phases of the illness: acute [prior to intravenous immunoglobulin (IVIG) treatment], sub-acute (5–10 days after IVIG treatment), and convalescent (1–4 months after KD diagnosis). Seventy children were included in the final cohort of the study, of whom 26 (37%) presented with CAL and 18 (26%) developed IVIG resistance. The patients included in this study came from diverse ethnic backgrounds, mostly with mixed ancestry/ ethnicity. Significantly increased PTX-3 levels were observed during the acute phase of KD compared to the sub-acute and the convalescent phases. The PTX-3 levels during acute KD were significantly higher among KD patients with CAL compared to patients with normal coronary arteries (NCA). Also, the PTX-3 levels were significantly higher in patients with IVIG resistance. Furthermore, the PTX-3 levels were significantly higher in IVIG-resistant KD patients with CAL as compared to the NCA group. Moreover, the PTX-3 levels were significantly correlated to coronary artery z-score during acute KD and to neutrophil counts throughout KD progression regardless of coronary artery z-score. Elevated PTX-3 levels correlated to elevated neutrophil counts, a known source of PTX-3 in acute inflammation and an important player in the development of KD vasculitis. We, therefore, suggest PTX-3 as a novel factor in the development of KD-associated CAL and propose neutrophil-derived PTX-3 as contributing to KD vascular dysfunction.

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Pentraxin 3 as a novel diagnostic marker in neonatal sepsis

Cited by 16 publications

References 23 publications

Assessment of Cardiac Functions in Neonatal Sepsis

Assessment of Cardiac Functions in Neonatal Sepsis

Pentraxin 3 (PTX3): A Molecular Marker of Endothelial Dysfunction in Chronic Migraine

Elevated Levels of Pentraxin 3 Correlate With Neutrophilia and Coronary Artery Dilation During Acute Kawasaki Disease

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