2017
DOI: 10.1177/1747493017696099
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Penumbra and re-canalization acute computed tomography in ischemic stroke evaluation: PRACTISE study protocol

Abstract: Word Count= 6047 Tables and figures=03 Abstract: Rationale:Multimodal imaging, including CT angiography (CTA) and CT perfusion (CTP) imaging, yields additional information on intracranial vessels and brain perfusion, and can differentiate between ischaemic core and penumbra which may affect patient selection for intravenous thrombolysis.Hypothesis:

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Cited by 12 publications
(19 citation statements)
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References 80 publications
(105 reference statements)
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“…Using the American ASITN/SIR collateral circulation grading system, the status of cerebral collateral circulation was classified into 5 levels [4]: level 0: no collateral vessels on the ischemic side; level 1: partial collateral circulation formation in the late venous phase; level 2: partial collateral circulation formation in the ischemic area before the venous phase; level 3: complete blood flow to the ischemic foci in the late venous phase; level 4: complete collateral circulation formation before the venous phase (Figures 1 to 3). Grades 0-2 are poor collateral circulation, and grades 3-4 are good collateral circulation.…”
Section: Inspection Methodmentioning
confidence: 99%
See 1 more Smart Citation
“…Using the American ASITN/SIR collateral circulation grading system, the status of cerebral collateral circulation was classified into 5 levels [4]: level 0: no collateral vessels on the ischemic side; level 1: partial collateral circulation formation in the late venous phase; level 2: partial collateral circulation formation in the ischemic area before the venous phase; level 3: complete blood flow to the ischemic foci in the late venous phase; level 4: complete collateral circulation formation before the venous phase (Figures 1 to 3). Grades 0-2 are poor collateral circulation, and grades 3-4 are good collateral circulation.…”
Section: Inspection Methodmentioning
confidence: 99%
“…erefore, a fast and accurate automatic stroke lesion segmentation method is urgently needed to treat more patients in a short period of time. Convolutional Neural Networks (CNNs) and their continuously evolving network structures have excellent performance in semantic segmentation tasks [4]. However, these CNNs-based network models require a large amount of labeled data for training, and the cost of data labeling for medical images is significant.…”
Section: Introductionmentioning
confidence: 99%
“…A clinically representative sample (equivalent to the patient population for whom e-ASPECTS or e-CTA may routinely be used) of baseline NECT brain and CTA scans will be selected from the following 10 multicentre national and international randomised-controlled trials (RCTs) and observational studies of stroke: Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST) 9 ; European multicentre, randomised, phase III clinical trial of therapeutic hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke (EuroHyp-1) 10 ; Third International Stroke Trial (IST-3) 11 ; Lothian study of INtraCerebral Haemorrhage Pathology, Imaging and Neurological outcome (LINCHPIN) 12 ; Pragmatic Ischaemic Thrombectomy Evaluation (PISTE) 13 ; POst-Stroke Hyperglycaemia (POSH) 14 ; Penumbra and Recanalisation Acute Computed Tomography in Ischaemic Stroke Evaluation (PRACTISE) 15 ; REstart or STop Antithrombotics Randomised Trial (RESTART) 16 ; Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) 17 ; Safe Implementation of Treatments in Stroke (SITS) open study 18 . These trials collectively include over 6600 individual patients accessible to RITeS; see Table 1 for individual trial numbers and details of available imaging.…”
Section: Patient Populationmentioning
confidence: 99%
“…Additional acquisition and processing time for multimodal CT assessment may delay administration of thrombolytic treatment, with typical average times for acquisition of multimodal imaging of 15 minutes. Whether the potential reduction in benefit resulting from this delay is mitigated by improved patient selection and consequently better outcomes within the 4.5 hours time window are under investigation in the ongoing Penumbra and Recanalisation Acute Computed Tomography in Ischaemic Stroke Evaluation (PRACTISE) trial …”
Section: Discussionmentioning
confidence: 99%