Peptide correction of disturbed intercentral relations

Abstract

Effects of peptides with opioid activity (8-sleep peptide, tetrapeptidamide, and taftsin) are studied in animals with disturbed intercentral relations (psychomotor excitation or penicillin epilepsy). 5-Sleep peptide and tetrapeptidamide suppress brain structure responses to photoand acoustic stimulants. All peptides alter the multisensory characteristics of the structures. In disease, peptidergic mechanisms regulate afferent flows to brain structures. Pathological states of the central nervous system have been regarded as a result of discoordination between brain structures. However, this assumption is rather abstract and allows many interpretations. According to one of them, functional interactions (or integration) of brain structures is a principal scheme of distribution and regulation of afferent flows. Distortions of such a scheme lead to disease and its restoration to correction and compensation [6]. From this viewpoint we shall regard neuropsychotropic effects of 5-sleep peptides (DSP) and tetrapeptidamide possessing opioid activity and those of taftsin, a wellknown stimulant of the central nervous system. Systemic restructuring provoked by a single injection of each of these peptides to intact animals and animals with central nervous system diseases was assessed in higher animals by bioelectric activity of the brain: electroencephalogram, evoked potentials (EP), and their analogs or reproduced EP configurations between the signals. MATERIALS AND METHODSExperiments were carded out on dogs and cats with chronically implanted electrodes. In dogs, the electrodes were implanted in the visual analyzer structures (fields O~ and O2), external geniculate body, motor field, caudate nucleus, pale globe, adjacent nucleus, and intralaminar nuclei of the thalamus. A Institute of Brain, Russian Academy of Medical Sciences, Moscow defense habit was developed in dogs: a series of 6 light flashes (2 Hz) was combined with suprathreshold electrostimulation of the fore paw between the fifth and sixth flash.Electroencephalogram and EP were recorded with a 9-circuit oscillographer (pass band up to 2000 Hz, time constant 1 sec). Similarity of EP analog configuration to configuration of EP recorded in response to sensory stimulator was the criterion for distinguishing EP analogs. The presence of EP analogs, their configuration, amplitude and time, and relation to the motor reaction were assessed.In cats, the electrodes were implanted in sensorimotor, acoustic, and visual cortical zones, in caudate nuclei, hippocampus, central medial nuclei of the thalamus, and in anterior two-hillock area.Electroencephalograms were recorded with a 16-channel encephalographer (RIS) with time constant 0.05 sec and upper pass band 150 Hz.