Effects of peptides with opioid activity (8-sleep peptide, tetrapeptidamide, and taftsin) are studied in animals with disturbed intercentral relations (psychomotor excitation or penicillin epilepsy). 5-Sleep peptide and tetrapeptidamide suppress brain structure responses to photoand acoustic stimulants. All peptides alter the multisensory characteristics of the structures. In disease, peptidergic mechanisms regulate afferent flows to brain structures. Pathological states of the central nervous system have been regarded as a result of discoordination between brain structures. However, this assumption is rather abstract and allows many interpretations. According to one of them, functional interactions (or integration) of brain structures is a principal scheme of distribution and regulation of afferent flows. Distortions of such a scheme lead to disease and its restoration to correction and compensation [6]. From this viewpoint we shall regard neuropsychotropic effects of 5-sleep peptides (DSP) and tetrapeptidamide possessing opioid activity and those of taftsin, a wellknown stimulant of the central nervous system. Systemic restructuring provoked by a single injection of each of these peptides to intact animals and animals with central nervous system diseases was assessed in higher animals by bioelectric activity of the brain: electroencephalogram, evoked potentials (EP), and their analogs or reproduced EP configurations between the signals. MATERIALS AND METHODSExperiments were carded out on dogs and cats with chronically implanted electrodes. In dogs, the electrodes were implanted in the visual analyzer structures (fields O~ and O2), external geniculate body, motor field, caudate nucleus, pale globe, adjacent nucleus, and intralaminar nuclei of the thalamus. A Institute of Brain, Russian Academy of Medical Sciences, Moscow defense habit was developed in dogs: a series of 6 light flashes (2 Hz) was combined with suprathreshold electrostimulation of the fore paw between the fifth and sixth flash.Electroencephalogram and EP were recorded with a 9-circuit oscillographer (pass band up to 2000 Hz, time constant 1 sec). Similarity of EP analog configuration to configuration of EP recorded in response to sensory stimulator was the criterion for distinguishing EP analogs. The presence of EP analogs, their configuration, amplitude and time, and relation to the motor reaction were assessed.In cats, the electrodes were implanted in sensorimotor, acoustic, and visual cortical zones, in caudate nuclei, hippocampus, central medial nuclei of the thalamus, and in anterior two-hillock area.Electroencephalograms were recorded with a 16-channel encephalographer (RIS) with time constant 0.05 sec and upper pass band 150 Hz.

So-called analogs of evoked potentials can be regarded as a reliable criterion for assessing the transformation of trace processes in outpacing excitation. Dogs were injected with the dopamine antagonist haloperidol at the stage of stabilization of a motor conditioned reflex. The configuration of the evoked potential analogs in the motor cortex and basal ganglia became of the same type, without visible pathological symptoms. Evoked potential analogs with simple and complex (M) configuration were recorded after administration of L-DOPA. Specific distortions of trace processes were observed at subclinical stages of dopamine pathology. Key Words: analogues of evoked potentials; dopamine-related d&ordeG" trace processesIt has been generally accepted that prediction is based on the memorizing of biologically significant situations. Experiments have shown that probabilistic prediction is based on the formation of trace processes which gradually transform into outpacing excitation [2,4]. So-called analogs of evoked potentials (EP) or the dynamics of the reproduction of EP configuration during the intersignal period are an objective criterion for the assessment of trace processes [1,4].Stabilization of EP parameters and configuration during training suggests that the ratio of afferentations to a given brain structure is not random and l-effects the functional role of this structure. The emergence of EP analogs indicates that the reproduction of the traces of the given afferentation complex is necessary for the solution of adaptive task. In fact, typical EP analogs exist for each structure at each level of training [4,5].During training the dynamics of EP analogs first lags behind than outpaces the EP dynamics. Institute of Brain Research, Ru,ssian Academy of Medical Sciences, MoscowConsequently, EP analogs react earlier than EP to changes in afferentations. This is particularly important for situations when the afferentation complexes are pathologically distorted; this occurs, for example, in modeled DOPA-dependent sylnptoms. The restriction of motor afferent complexes was observed in neuroleptical parkinsonism; psychomotor excitation caused by L-DOPA was accompanied by afferent overload [5]. The dynamics of trace processes that outpace excitation remains unclear under conditions of dopamine-related disorders. The dynamics of EP analogs allows one to monitor these processes in various brain divisions, including the analyzing and extrapyramidal structures. This is particularly important for the early, symptom-free stages of dopamine-related disorders since it is reasonable to expect that it will be reflected by the dynamics of EP analogs.Our objective was to find out how tmcc processes are related to contralateral changes in dopamine lnetabolism. Bearing in mind the postulate tliat brain functions are associated with preseJvation of the traces of previous processes in brain structures, the identification of the early inanifestations of