2020
DOI: 10.1021/acs.biomac.0c00911
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Peptide Fibrillar Assemblies Exhibit Membranolytic Effects and Antimetastatic Activity on Lung Cancer Cells

Abstract: Cancer metastasis is a central oncology concern that worsens patient conditions and increases mortality in a short period of time. During metastatic events, mitochondria undergo specific physiological alterations that have emerged as notable therapeutic targets to counter cancer progression. In this study, we use drug-free, cationic peptide fibrillar assemblies (PFAs) formed by poly(L-Lysine)-block-poly(L-Threonine) (Lysb-Thr) to target mitochondria. These PFAs interact with cellular and mitochondrial membrane… Show more

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Cited by 7 publications
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