Peptide - Mediated Delivery of siRNA via Noncovalent Complexes and Covalent Conjugates

Witkowska, R; Ahmadian, Mohammad; Dattilo, James; Purvis, Lafe J.; Mayer, Sasha J.; Chen, Lishan; Chen, Yuching; Cui, Kunyuan; Farber, Ken; Roth, Sharin E.; Houston, Michael E.; Johnson, Paul; Quay, Steven C.

doi:10.1007/978-0-387-26575-9_189

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Plasma Membrane Translocation1

Dicer Substrate Conjugates1

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“…Witkowska et al [84] have characterized several groups of cell-penetrating peptides from published and designed sequences representing a variety of chemical properties for siRNA delivery in vitro as well as in vivo. Witkowska et al [84] have characterized several groups of cell-penetrating peptides from published and designed sequences representing a variety of chemical properties for siRNA delivery in vitro as well as in vivo.…”

Section: Plasma Membrane Translocationmentioning

confidence: 99%

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Discovery of New SiRNA Delivery Agents

et al. 2010

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Section: Plasma Membrane Translocationmentioning

confidence: 99%

“…Witkowska et al [84] have described methods for synthesis and conjugation of peptides to siRNA. Peptides can be efficiently synthesized by the solid phase methods using standard Fmoc chemistry and conjugated to duplex RNA as described in Figure 5.3.…”

Section: Dicer Substrate Conjugatesmentioning

confidence: 99%