Peptide Micelle-Mediated Delivery of Tissue-Specific Suicide Gene and Combined Therapy with Avastin in a Glioblastoma Model

Oh, Binna; Han, Jaesik; Choi, Eun‐Ji; Tan, Xiaonan; Lee, Minhyung

doi:10.1002/jps.24363

Cited by 9 publications

(6 citation statements)

References 37 publications

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“…Combination treatment involving both dual-specific TK gene and bevacizumab inhibited the growth of tumor. Oh, et al 16 reported that combination therapy involving both glioblastoma-specific TK gene/R7L10 with bevacizumab to treat brain tumor reduced the tumor volume by approximately 50%. Also, combination therapy with mesenchymal-epithelial tran- sition factor siRNA and VEGF siRNA for the reduction of VEGF expression decelerated cell growth more efficiently as compared to siRNA transfection alone.…”

Section: Discussionmentioning

confidence: 99%

“…Many studies have reported the ability of tissue-specific genes to reduce such side effects and enhance the effects of therapeutic genes. 35 Oh, et al 16 reported that complexes of R7L10 peptide/glioblastoma-specific TK gene with bevacizumab increased the therapeutic effect of the HSV-TK gene on glioblastoma in the brain. Also, these complexes using a low dose of PEI did not show tissue damage after intravenous injection.…”

Section: Discussionmentioning

confidence: 99%

“…14 The glioma dual-specific TK gene increases the therapeutic efficacy in brain tumor tissues without side effect. 15,16 Transcription regulation has been investigated using tissuespecific promoters, such as the glial fibrillary acidic protein (GFAP) promoter or nestin intron 2 (NI2). 17,18 Kim, et al 15 reported that the use of Epo enhancer with NI2 dual-specific herpes simplex virus thymidine kinase gene (HSV-TK) and ganciclovir (GCV) is a powerful gene therapy strategy for malignant gliomas.…”

Section: Introductionmentioning

confidence: 99%

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Combination Therapy by Tissue-Specific Suicide Gene and Bevacizumab in Intramedullary Spinal Cord Tumor

et al. 2020

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Purpose: Malignant gliomas are aggressive spinal cord tumors. In this study, we hypothesized that combination therapy using an anti-angiogenic agent, bevacizumab, and hypoxia-inducible glioblastoma-specific suicide gene could reduce tumor growth. Materials and Methods: In the present study, we evaluated the effect of combination therapy using bevacizumab and pEpo-NI2-SV-TK in reducing the proliferation of C6 cells and tumor growth in the spinal cord. Spinal cord tumor was generated by the injection of C6 cells into the T5 level of the spinal cord. Complexes of branched polyethylenimine (bPEI)/pEpo-NI2-SV-TK were injected into the spinal cord tumor. Bevacizumab was then administered by an intraperitoneal injection at a dose of 7 mg/kg. The anti-cancer effects of combination therapy were analyzed by histological analyses and magnetic resonance imaging (MRI). The Basso, Beattie and Bresnahan scale scores for all of the treatment groups were recorded every other day for 15 days to assess the rat hindlimb strength. Results: The complexes of bPEI/pEpo-NI2-SV-TK inhibited the viability of C6 cells in the hypoxia condition at 5 days after treatment with ganciclovir. Bevacizumab was decreased in the cell viability of human umbilical vein endothelial cells. Combination therapy reduced the tumor size by histological analyses and MRI. The combination therapy group showed improved hind-limb function compared to the other groups that were administered pEpo-NI2-SV-TK alone or bevacizumab alone. Conclusion: This study suggests that combination therapy using bevacizumab with the pEpo-NI2-SV-TK therapeutic gene could be useful for increasing its therapeutic benefits for intramedullary spinal cord tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combination Therapy by Tissue-Specific Suicide Gene and Bevacizumab in Intramedullary Spinal Cord Tumor

et al. 2020

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“…For example, Oh et al revealed that the cytotoxicity of PEI vectors was significantly higher than R7L10. R7L10 is a short amphiphilic peptide micelle that is chemically synthesized [107]. They used a suicide gene, herpes simplex virus thymidine kinase (HSVtk), for the gene delivery to GBM.…”

Section: Brain Tumor-targeted Gene Deliverymentioning

confidence: 99%

“…Besides, combination therapy of avastin with pEpo-NI2-SV-HSVtk/R7L10 had a synergistic effect on tumor growth inhibition. Hence, it seems that R7L10 is safer than PEI and conjugation with Epo enhances its gene and drug delivery efficacy in hypoxia condition [107].…”

Section: Brain Tumor-targeted Gene Deliverymentioning

confidence: 99%

In vivo gene delivery mediated by non-viral vectors for cancer therapy

Mohammadinejad

Dehshahri

Madamsetty

et al. 2020

Journal of Controlled Release

192

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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The Medical Applications of Nanomaterials in the Central Nervous System

Jiang

2017

Neurotoxicity of Nanomaterials and Nanomedicine

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Peptide Micelle-Mediated Delivery of Tissue-Specific Suicide Gene and Combined Therapy with Avastin in a Glioblastoma Model

Cited by 9 publications

References 37 publications

Combination Therapy by Tissue-Specific Suicide Gene and Bevacizumab in Intramedullary Spinal Cord Tumor

Combination Therapy by Tissue-Specific Suicide Gene and Bevacizumab in Intramedullary Spinal Cord Tumor

In vivo gene delivery mediated by non-viral vectors for cancer therapy

The Medical Applications of Nanomaterials in the Central Nervous System

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