Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH

Komatsu, Masayuki; Biyani, Madhu; Gautam, Sunita Ghimire; Nishigaki, Koichi

doi:10.1155/2012/316432

Cited by 17 publications

(31 citation statements)

References 22 publications

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“…This form has been studied in the context of axion (Kawasaki et al 2008) and curvaton scenarios (Langlois, Vernizzi & Wands 2008). The bispectra are calculated as (Komatsu 2002)…”

Section: Quadratic-type Isocurvature Componentmentioning

confidence: 99%

Adiabatic versus isocurvature non-Gaussianity

Munshi

Heavens

Coles³

2010

Monthly Notices of the Royal Astronomical Society

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We study the extent to which one can distinguish primordial non‐Gaussianity (NG) arising from adiabatic and isocurvature perturbations. We make a joint analysis of different NG models based on various inflationary scenarios: local‐type and equilateral‐type NG from adiabatic perturbations and local‐type and quadratic‐type NG from isocurvature perturbations together with a foreground contamination by point sources. We separate the Fisher information of the bispectrum of cosmic microwave background temperature and polarization maps by l for the skew spectrum estimator introduced by Munshi and Heavens to study the scale dependence of the signal‐to‐noise ratio of different NG components and their correlations. We find that the adiabatic and the isocurvature modes are strongly correlated, though the phase difference of acoustic oscillations helps to distinguish them. The correlation between local‐ and equilateral‐type is weak, but the two isocurvature modes are too strongly correlated to be discriminated. Point source contamination, to the extent to which it can be regarded as white noise, can be almost completely separated from the primordial components for l > 100. Including correlations among the different components, we find that the errors of the NG parameters increase by 20–30 per cent for the Wilkinson Microwave Anisotropy Probe 5‐year observation, but ≃5 per cent for Planck observations.

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“…This form has been studied in the context of axion (Kawasaki et al 2008) and curvaton scenarios (Langlois, Vernizzi & Wands 2008). The bispectra are calculated as (Komatsu 2002)…”

Section: Quadratic-type Isocurvature Componentmentioning

confidence: 99%

Adiabatic versus isocurvature non-Gaussianity

Munshi

Heavens

Coles³

2010

Monthly Notices of the Royal Astronomical Society

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“…This paper is organized as follows: in Section 2 we summarize the observations and data reduction, in Section 3 we present the results, in Section 4 we discuss the implications and in Section 5 we conclude. Throughout this work, we assume the 7-yr Wilkinson Microwave Anisotropy Probe (WMAP) cosmological model of Komatsu et al (2010), though any set of cosmological parameters within reason will not qualitatively change the interpretation of these results. Finally, we assume a Chabrier (2003) stellar initial mass function (IMF; see below and discussion on applicability to SMGs in Tacconi et al 2008) and when the redshift of a source is uncertain we consider a range of 2 z 4 (also appropriate for SMGs; see e.g.…”

Section: Introductionmentioning

confidence: 99%

The physical scale of the far-infrared emission in the most luminous submillimetre galaxies - II. Evidence for merger-driven star formation

Younger

Fazio

Civano

et al. 2010

Monthly Notices of the Royal Astronomical Society

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We present high‐resolution 345‐GHz interferometric observations of two extremely luminous (Lir≳ 1013 L⊙), submillimetre‐selected galaxies (SMGs) in the Cosmic Evolution Survey (COSMOS) field with the Submillimeter Array (SMA). Both targets were previously detected as unresolved point sources by the SMA in its compact configuration, also at 345 GHz. These new data, which provide a factor of ≳3 improvement in resolution, allow us to measure the physical scale of the far‐infrared in the submillimetre directly. The visibility functions of both targets show significant evidence for structure on ∼0.5–1‐arcsec scales, which at z≳ 1.5 translates into a physical scale of ∼5–8 kpc. Our results are consistent with the angular and physical scales of two comparably luminous objects with high‐resolution SMA follow‐up, as well as radio continuum and CO sizes of other SMGs. These relatively compact sizes (≲5–10 kpc) argue strongly for merger‐driven starbursts, rather than extended gas‐rich discs, as the preferred channel for forming SMGs.

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“…The PP library (the third library) was constructed by random shuffling of eight peptide blocks selected from the first and second libraries (Table ) using YLBS as shown in Figure S1. So, the peptide blocks selected from the first and second libraries act as the parent peptide blocks for the paired peptides selected from the third library.…”

Section: Resultsmentioning

confidence: 99%

Strong Inhibition of Beta‐Amyloid Peptide Aggregation Realized by Two‐Steps Evolved Peptides

2014

Self Cite

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Several decades of cumulated research evidence have proven that aggregation of beta-amyloid 42 (Aβ42) is the main cause of neuronal death in the brains of patients with Alzheimer's disease. Therefore, inhibition of Aβ42 aggregation holds great promise for the prevention and treatment of Alzheimer's disease. To this end, we used a systematic in vitro evolution including a paired peptide library method. We identified two peptides with high binding affinity (with Kd in the nm range) for Aβ42. Functionally, these peptides strongly inhibited the aggregation of Aβ42 as shown by the thioflavin T assay and atomic force microscopy. Moreover, these peptides rescued PC12 cells from the cytotoxic effect of aggregated Aβ42 in vitro. Our results suggest that these novel peptides may be potential therapeutic seeds for the treatment of Alzheimer's disease.

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Peptide-Modulated Activity Enhancement of Acidic Protease Cathepsin E at Neutral pH

Cited by 17 publications

References 22 publications

Adiabatic versus isocurvature non-Gaussianity

Adiabatic versus isocurvature non-Gaussianity

The physical scale of the far-infrared emission in the most luminous submillimetre galaxies - II. Evidence for merger-driven star formation

Strong Inhibition of Beta‐Amyloid Peptide Aggregation Realized by Two‐Steps Evolved Peptides

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