Peptide NGR Modified TiO2 Nanofiber Substrate for Circulating Tumor Cells Capture

Chen, Changchong; Wu, Zeen; Ding, Pi; Sun, Na; Liu, Hui; Chen, Yong; Wang, Zhili; Pei, Renjun

doi:10.1007/s42765-020-00040-0

Cited by 51 publications

(25 citation statements)

References 30 publications

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“…To construct D-𝜋-A-𝜋-D typed photothermal molecules with strong TICT properties and active intramolecular motions, dimethylamine-functionalized TPE was selected as the electron donor, which also acts as the molecular rotors to dissipate the excited energy via heat relaxation (Figure 1a). Two electron-deficient low bandgap units, namely BBTD and 6-(2-ethylhexyl)- [1,2,5] thiadiazole [3,4-F] benzotriazole (TBZ), were selected as the acceptor to introduce strong intramolecular charge transfer (ICT) characteristics. A long alkyl chain grafted thiophene was selected as the 𝜋 bridge to facilitate the charge transfer (CT) from TPE to BBTD or TBZ.…”

Section: Synthesis and Characterization Of Photothermal Moleculesmentioning

confidence: 99%

“…[1] Great efforts have been made to fight against cancers over decades. [2][3][4][5] Among these malignant tumors, urinary bladder cancer, especially muscle-invasive bladder cancer (MIBC) remains to be big challenges of clinical treatment. [6] The heterogeneous and complex tissue environment of MIBC usually result in high recurrence and metastasis for traditional intravesical therapy or transurethral resection of the bladder tumor, which often proceeds to the stage of bladder radical cystectomy to completely remove bladder.…”

Section: Introductionmentioning

confidence: 99%

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Boosting Photothermal Theranostics via TICT and Molecular Motions for Photohyperthermia Therapy of Muscle‐Invasive Bladder Cancer

Zhang

Hong

et al. 2021

Adv Healthcare Materials

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The development of photothermal agents with high photothermal conversion efficiency (PCE) can help to reduce drug and laser dosage, but still remains a big challenge. Herein, a novel approach is reported to design photothermal agents with high PCE values by promoting nonradiative heat generation processes through the cooperation of twisted intramolecular charge transfer (TICT) and molecular motions. Within the designed molecule 2DMTT-BBTD, the tetraphenylethenes act as molecular rotors, the long alkyl chain grafted thiophene helps to twist the molecular geometry to facilitate TICT state formation and preserve molecular motions in aggregate, while the strong electron-withdrawing BBTD unit enhances TICT effect. 2DMTT-BBTD exhibits NIR-absorption and a high PCE value of 74.8% under 808 nm laser irradiation. Gambogic acid (GA) which surmounts tumor cell thermotolerance by inhibiting heat shock protein 90 (HSP90) expression is coloaded into the nanoparticles, RGD peptide is further introduced to the nanoparticle surface to improve tumor accumulation. The resultant nanoparticles facilitate the effective low-temperature hyperthermia therapy of muscle-invasive bladder cancer (MIBC) with minimal damage to surrounding heathy tissues. This work delivers a new design concept for development of highly efficient photothermal agents, which also provides a safer approach for noninvasive treatment of MIBC and other malignant tumors.

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Section: Synthesis and Characterization Of Photothermal Moleculesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Boosting Photothermal Theranostics via TICT and Molecular Motions for Photohyperthermia Therapy of Muscle‐Invasive Bladder Cancer

Zhang

Hong

et al. 2021

Adv Healthcare Materials

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“…Numerous carriers can be applied to facilitate oral absorption, including enteric soluble materials and mucus penetration materials. Although various nanoparticle-based strategies have been studied, including micelles, nano-emulsions, solid lipid nanoparticles, nanofibers, and dendrimers [ 9 – 11 ], only a few oral nanoparticles have entered clinical research. This might be due to low GIT stability and poor therapeutic efficacy.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs

et al. 2022

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Background Oral chemotherapy is preferred for patients with cancer owing to its multiple advantages, including convenience, better patient compliance, and improved safety. Nevertheless, various physical barriers exist in this route that hamper the development of oral chemotherapeutic formulations, including destruction of drugs in the gastrointestinal tract (GIT), low permeability in enterocytes, and short residence time in the intestine. To overcome these limitations, it is necessary to design an efficient oral drug delivery system with high efficacy and improved safety. Results Herein, we designed novel glycocholic acid (GCA)-functionalized double layer nanoparticles (GCA-NPs), which can act via an endogenous pathway and in a temporally controlled manner in the intestine, to enhance the oral bioavailability of hydrophobic chemotherapeutic drugs such as paclitaxel (PTX). GCA-NPs were composed of quercetin (Qu)-modified liposomes (QL) coated with GCA-chitosan oligosaccharide conjugate (GCOS). The GCA-NPs thus prepared showed prolonged intestinal retention time and good GIT stability due to the presence of chitosan oligosaccharide (COS) and enhanced active transportation via intestinal apical sodium-dependent bile acid transporter (ASBT) due to the presence of GCA. GCA-NPs also efficiently inhibited intestinal P-gp induced by Qu. PTX-loaded GCA-NPs (PTX@GCA-NPs) had a particle size of 84 nm and an entrapment efficiency of 98% with good stability. As a result, the oral bioavailability of PTX was increased 19-fold compared to that of oral Taxol® at the same dose. Oral PTX@GCA-NPs displayed superior antitumor efficacy and better safety than Taxol® when administered intravenously. Conclusions Our novel drug delivery system showed remarkable efficacy in overcoming multiple limitations and is a promising carrier for oral delivery of multiple drugs, which addresses several challenges in oral delivery in the clinical context. Graphical Abstract

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“…CuS NPs served as a photothermal agent. With the surface modification with bovine serum albumin (BSA) molecules, as a biocompatible template for the synthesis of NPs, an antifouling molecule and a viable drug carrier for chemotherapeutic drugs, which could stabilize nanostructures, reduce the adhesion of blood cells to improve the capture purity of HCC [ 22 , 32 ]. Doxorubicin (DOX) loading and NIR-responsible release behavior were carefully investigated.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible copper sulfide–based nanocomposites for artery interventional chemo-photothermal therapy of orthotropic hepatocellular carcinoma

Tian

Tang

et al. 2021

Materials Today Bio

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Transcatheter arterial embolization has been considered as a promising targeted delivery approach for hepatocellular carcinoma (HCC). Currently, chemoembolization was the main treatment for unresectable HCC. However, the traditional chemoembolization treatment suffers from undesirable therapeutic effects and serious side-effects. In this study, the doxorubicin (DOX)-encapsulated and near-infrared (NIR)–responsible copper sulfide (CuS)–based nanotherapeutics was developed for magnetic resonance imaging (MRI)–guided chemo-photothermal therapy of HCC tumor in rats. The DOX-loaded CuS nanocomposites (DOX@BSA-CuS) demonstrated distinct NIR-triggered drug release behavior and high photothermal effect. In an orthotopic HCC rat model, DOX@BSA-CuS nanocomposites were selectively delivered to the tumor site via the intra-arterial transcatheter. The proposed DOX@BSA-CuS nanocomposites plus NIR laser irradiation exhibited significant tumor growth suppression performance. Moreover, the treatment progress can be monitored by MRI images. Finally, the preliminary toxicity estimate suggested the negligible side-effect of DOX@BSA-CuS nanocomposites during the therapeutic process. These results suggest the clinical translational potential possibility for imaging-guided arterial embolization with DOX@BSA-CuS nanocomposites for the treatment of HCC.

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Peptide NGR Modified TiO2 Nanofiber Substrate for Circulating Tumor Cells Capture

Cited by 51 publications

References 30 publications

Boosting Photothermal Theranostics via TICT and Molecular Motions for Photohyperthermia Therapy of Muscle‐Invasive Bladder Cancer

Boosting Photothermal Theranostics via TICT and Molecular Motions for Photohyperthermia Therapy of Muscle‐Invasive Bladder Cancer

Biomimetic and temporal-controlled nanocarriers with ileum transporter targeting for achieving oral administration of chemotherapeutic drugs

Biocompatible copper sulfide–based nanocomposites for artery interventional chemo-photothermal therapy of orthotropic hepatocellular carcinoma

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