Peptide <scp>YY</scp>, neuropeptide Y and corticotrophin‐releasing factor modulate gastrointestinal motility and food intake during acute stress

Forbes, Sarah; Cox, Helen

doi:10.1111/nmo.12428

Cited by 25 publications

(25 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The PYY-mediated mucosal results with Cpd 1, combined with previous data, suggest that FFA2 agonism leads to slowing of transit via PYY release. Indeed PYY 2/2 mice have significantly faster UGIT and colonic transit than WT mice (21,45) and PYY activates ileal and colonic brakes under normal and stressed conditions (21,46). Here, DIO resulted in a higher proportion of fat mass and impaired glucose tolerance in FFA2 2/2 mice, although obese FFA2 2/2 and WT mice did not have different body weights.…”

Section: Discussionmentioning

confidence: 90%

Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models

et al. 2015

View full text Add to dashboard Cite

Free fatty acid receptor 2 (FFA2) is expressed on enteroendocrine L cells that release glucagon-like peptide 1 (GLP-1) and peptide YY (PYY) when activated by shortchain fatty acids (SCFAs). Functionally GLP-1 and PYY inhibit gut transit, increase glucose tolerance, and suppress appetite; thus, FFA2 has therapeutic potential for type 2 diabetes and obesity. However, FFA2-selective agonists have not been characterized in vivo. Compound 1 (Cpd 1), a potent FFA2 agonist, was tested for its activity on the following: GLP-1 release, modulation of intestinal mucosal ion transport and transit in wild-type (WT) and FFA2 2/2 tissue, and food intake and glucose tolerance in lean and diet-induced obese (DIO) mice. Cpd 1 stimulated GLP-1 secretion in vivo, but this effect was only detected with dipeptidyl peptidase IV inhibition, while mucosal responses were PYY, not GLP-1, mediated. Gut transit was faster in FFA2 2/2 mice, while Cpd 1 slowed WT transit and reduced food intake and body weight in DIO mice. Cpd 1 decreased glucose tolerance and suppressed plasma insulin in lean and DIO mice, despite FFA2 2/2 mice displaying impaired glucose tolerance. These results suggest that FFA2 inhibits intestinal functions and suppresses food intake via PYY pathways, with limited GLP-1 contribution. Thus, FFA2 may be an effective therapeutic target for obesity but not for type 2 diabetes.

show abstract

Section: Discussionmentioning

confidence: 90%

Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In fact, the local release of some neuropeptides into the enteric nervous system could play a role in the pathophysiology of IBS, but these neuropeptides cannot be assayed in the serum because they spread in a paracrine way. As suggested by Forbes et al 25 in a mouse model, NPY seems to directly inhibit the colonic motor response induced by the corticotrophin-releasing factor receptor activation during stress. Given that the local 5-HT release in the GI tract is involved in excitatory action on vagal afferent fibers and on contraction of smooth colonic muscle, 6 it is possible that indirect high levels of NPY try to maintain normal colonic motor response also during psychological distress, counteracting the effect of 5-HT release.…”

mentioning

confidence: 88%

Neuroendocrine Dysregulation in Irritable Bowel Syndrome Patients: A Pilot Study

Stasi

Bellini

Gambaccini

et al. 2017

J Neurogastroenterol Motil

View full text Add to dashboard Cite

Background/AimsIrritable bowel syndrome (IBS) is a multifactorial disorder, involving dysregulation of brain-gut axis. Our aim was to evaluate the neuroendocrine activity in IBS. MethodsThirty IBS and 30 healthy volunteers were enrolled. Psychological symptoms were evaluated by questionnaires. Urinary 5-hydroxyindoleacetic acid, plasma serotonin (5-hydroxytryptamine, 5-HT), endothelin, and neuropeptide Y (NPY), and plasma and urinary cortisol levels were evaluated. Fourteen IBS subjects underwent microneurography to obtain multiunit recordings of efferent postganglionic muscle sympathetic nerve activity (MSNA). ResultsPrevalent psychological symptoms in IBS were maladjustment (60%), trait (40%) and state (17%) anxiety, obsessive compulsivedisorders (23%), and depressive symptoms (23%). IBS showed increased NPY (31.9 [43.7] 1] pg/mL, P = 0.054], compared to healthy volunteers. Moreover, plasma NPY, endothelin, cortisol and 5-HT, and urinary 5-hydroxyindoleacetic acid were associated with some psychological disorders (P ≤ 0.05). Despite a similar resting MSNA, after cold pressor test, IBS showed a blunted increase in MSNA burst frequency (+4.1 vs +7.8 bursts/min, P = 0.048; +30.1% vs +78.1%, P = 0.023). Baseline MSNA tended to be associated with urinary cortisol (ρ = 0.557, P = 0.059). Moreover, changes in heart rate after mental stress were associated with urinary cortisol (ρ = 0.682, P = 0.021) and changes in MSNA after mental stress were associated with plasma cortisol (ρ = 0.671, P = 0.024)." ConclusionHigher concentrations of endothelin, NPY, and 5-HT were found to be associated with some psychological disorders in IBS patients together with an altered cardiovascular autonomic reactivity to acute stressors compared to healthy volunteers.

show abstract

“…However, one of the important functions is feeding regulation by NPY. It may act as a mediator between stress and food intake (Forbes, Herzog, & Cox, 2012;Forbes & Cox, 2014;Krolow et al, 2013), and the NPY neurons influence feeding behavior by the hypothalamus (Kim & Bi, 2016;van Swieten et al, 2014). In invertebrate insects, NPY was found only in few of Hymenoptera and Lepidoptera insects (Liu et al, 2013;Whitfield et al, 2002), and its function is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Feeding regulation by neuropeptide Y on Asian corn borer Ostrinia furnacalis

Yue

Zhao

2017

Arch Insect Biochem Physiol

View full text Add to dashboard Cite

The Asian Corn Borer Ostrinia furnacalis is a major agricultural pest. In this study, a full-length neuropeptide Y (npy) gene in O. furnacalis was sequenced and cloned from cDNA library, which contains an ORF of 273 bp by encoding 90 amino acid residues. The mature OfurNPY is composed of 29 amino acids with amidation in C-terminal. The spatiotemporal expression analysis showed that npy highest expression level was in the midgut of the fifth instar larvae (the gluttony period). When the expression of npy was knocked down by feeding or injecting dsNPY, larval food consumption, body size, and body weight were significantly inhibited compared to controls. These results indicate that NPY is an important regulator in the control of feeding of O. furnacalis.

show abstract

Peptide YY, neuropeptide Y and corticotrophin‐releasing factor modulate gastrointestinal motility and food intake during acute stress

Cited by 25 publications

References 37 publications

Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models

Selective FFA2 Agonism Appears to Act via Intestinal PYY to Reduce Transit and Food Intake but Does Not Improve Glucose Tolerance in Mouse Models

Neuroendocrine Dysregulation in Irritable Bowel Syndrome Patients: A Pilot Study

Feeding regulation by neuropeptide Y on Asian corn borer Ostrinia furnacalis

Contact Info

Product

Resources

About