1970
DOI: 10.1002/prac.19703120622
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Peptide. XVII. Über die Synthese von Homoarginin‐Bradykininen

Abstract: Es wird die Synthese von drei Analoga des Bradykinins beschrieben, in denen das Arginin in 1‐ oder 9‐Stellung, bzw. in beiden Positionen durch die homologe Aminosäure Homoarginin (ϵ‐Guanido‐α‐aminocapronsäure) ersetzt ist. Außerdem wird über eine modifizierte Synthese des Bradykinins berichtet.

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Cited by 15 publications
(4 citation statements)
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“…The syntheses of the protected nonapeptides were carried out in a modified prototype (Iindeberg, 1975;Brunfeldt et al, 1968) of the Schwarz/Mann Peptide Synthesizer (Schwarz/ Mann, Orangeburg, N.Y., USA). The amino acids were obtained from Ajinomoto Co., Inc., Tokyo, Japan, or from Tanabe Seiyaku Co., Osaka, Japan.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The syntheses of the protected nonapeptides were carried out in a modified prototype (Iindeberg, 1975;Brunfeldt et al, 1968) of the Schwarz/Mann Peptide Synthesizer (Schwarz/ Mann, Orangeburg, N.Y., USA). The amino acids were obtained from Ajinomoto Co., Inc., Tokyo, Japan, or from Tanabe Seiyaku Co., Osaka, Japan.…”
Section: Methodsmentioning
confidence: 99%
“…However, L-homoarginine has been substituted for L-arginine in hormones of non-neurohypophyseal origin, e.g. bradykinin (Arold & Stibenz, 1970;Reissmann et al, 1974), corticotrophic peptides (Tesser et al, 1973) and LHRH (Geiger el al., 1974Borvendeg et al, 1974.…”
mentioning
confidence: 99%
“…6-Chloro-1-(2-dime thy laminoethyl )-4-pheny lquinazolin-2(17f)-one ( 9) and 6-Chloro-2-(2-dimethylaminoethoxy) -4phenylquinazoline (10). Potassium fert-butoxide, 13 g (0.115 mol), was added to a solution of 25.6 g (0.1 mol) of 6-chloro-4phenylquinazolin-2(lif)-one5 in 150 ml of DMF.…”
Section: Methodsmentioning
confidence: 99%
“…Bradykininacetate (Sandoz, Basel); bradykinintrihydrochloridel); pentapeptide Phe-Gly-Pro-Phe-Argl); ACTH, corticotropin, Procortan forte R (VEB Arzneimittelwerk Dresden); propranololhydrochloride, Obsidan R (IsisChemie, Zwickau); theophylline, Theophyllinum DAB 7 I) Bradykinintrihydrochloride and Phe-Gly-Pro-Phe-Arg were synthesized by AROLD [ 19] and REISSMANN [20]. …”
Section: Substances Usedmentioning
confidence: 99%