Peptides and their constituent amino acids influence the immune response and phagocytosis in different ways

Belokrylov, G. A.; Popova, O. Ya.; Molchanova, I. V.; Sorochinskaya, E. I.; Anokhina, V. V.

doi:10.1016/0192-0561(92)90065-s

Cited by 18 publications

(11 citation statements)

References 3 publications

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“…In nonimmunized mice receiving test preparations, phagocytosis-modulating activity of peritoneal granulocytes was determined in vitro [1, 3,4]. Granulocytes were obtained by washing the abdominal cavity with sterile Hanks' solution 2.5 h after the intraperitoneal injection of 10% sterile peptone (Nutritional Biochemical Corporation).…”

Section: Methodsmentioning

confidence: 99%

Similarity of immunomodulating, phagocytosis-modulating, and antitoxic properties of dipeptides and their constituent amino acids

1999

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Section: Methodsmentioning

confidence: 99%

Similarity of immunomodulating, phagocytosis-modulating, and antitoxic properties of dipeptides and their constituent amino acids

1999

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“…The differences in the action of various doses of amino-acid preparations as well as in the effects of certain amino acids and peptides [4] on the immune response and phagocytosis attest to the relative autonomy of the specific and of nonspecific components of defense.…”

Section: R~u~smentioning

confidence: 96%

“…It has been shown that exposure of the organism to exogenous hyper- thermia leads to disturbances in the state of different organs and systems [2,4]. This provides an incentive to study the functional systems of the organism during hyperthermia and adaptation to heat and to seek ways of raising the organism's resistance under given conditions.…”

mentioning

confidence: 99%

Ambiguity of the effect of high and low doses of amino-acid preparations on the immune response and phagocytosis in mice

et al. 1994

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It is shown that the effect of amino-acid preparations (levamine-70-70, cerebrolysin, and aviamine) is dose-dependent. Thus, levamine-70 and cerebrolysin at 65 mg/kg do not affect the immune response but stimulate phagocytosis. Aviamine at 65 mg/kg inhibits the immune response but stimulates phagocytosis and in a dose of 6.5x10 -2 mg/kg boosts both processes.Key Words: levamine-70; cerebrolysin; aviamine; immune response; phagocytosisThe amino-acid preparations levamine-70 and cerebrolysin stimulate the thymus-dependent immune response when administered subcutaneously in mice in a range of low doses (6.5x10-~-6.5x10 -8 mg/kg) during 5 days [1]. The effect of these preparations on phagocytosis, a nonspecific index of resistance, has not been studied.Under clinical conditions levamine-70 and cerebrolysin are usually used in significantly higher doses, 0.65 mg/kg and 12.5 mg/kg, respectively.The aim of the present investigation was a comparative assessment of the effects of high and low doses of amino-acid preparations used in medical (levamine-70 and cerebrolysin) and veterinary (aviamine) practice on the thymus-dependent response and phagocytic activity of neutrophils (PAN) in mice. MATERIALS AND METHODSExperiments were carried out on 285 male CBA mice weighing 14-16 g. Finland), a mixture of isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine, histidine, arginine, alanine, proline, and glycine; cerebrolysin (Ebeve, Austria), a hydrolysate of brain tissue containing 18 amino acids, and aviamine (Drug Plant, St. Petersburg), a hydrolysate of hen blood casein containing 18 amino acids, were used.Cerebrolysin and aviamine were dosed by the protein content, which constituted 1 g/ml and 0.032 g/ml, respectively, whereas levamine-70 was dosed by the total content of amino acids (0.053 g /ml) and converted to kg of mass.The preparations dissolved in apyrogenic saline (Polfa, Poland) were injected s.c. in a range of doses 65.0-6.5x10 -1~ mg/kg during 5 days. Then some of the treated mice were immunized with

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“…Whey protein is thought to be the highest quality protein available, as compared to other proteins, such as ovalbumin, casein, beef meat, or soy. Whey protein contains all the essential and non-essential amino acids and is an excellent source of glutamine and branched-chain amino acids, which are necessary for cell growth [36]. Thus, whey contains high levels of amino acids that are important for wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…Various spatial arrangements of amino acids in whey protein influence immune responses in different ways [36]. Therefore, it has been hypothesized that unique amino acid groups or peptides derived from whey proteins after ingestion can have significant immunomodulatory activities.…”

Section: Introductionmentioning

confidence: 99%

Wound healing: time to look for intelligent, ‘natural’ immunological approaches?

2017

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There is now good evidence that cytokines and growth factors are key factors in tissue repair and often exert anti-infective activities. However, engineering such factors for global use, even in the most remote places, is not realistic. Instead, we propose to examine how such factors work and to evaluate the reparative tools generously provided by ‘nature.’ We used two approaches to address these objectives. The first approach was to reappraise the internal capacity of the factors contributing the most to healing in the body, i.e., blood platelets. The second was to revisit natural agents such as whey proteins, (honey) bee venom and propolis. The platelet approach elucidates the inflammation spectrum from physiology to pathology, whereas milk and honey derivatives accelerate diabetic wound healing. Thus, this review aims at offering a fresh view of how wound healing can be addressed by natural means.

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Peptides and their constituent amino acids influence the immune response and phagocytosis in different ways

Cited by 18 publications

References 3 publications

Similarity of immunomodulating, phagocytosis-modulating, and antitoxic properties of dipeptides and their constituent amino acids

Similarity of immunomodulating, phagocytosis-modulating, and antitoxic properties of dipeptides and their constituent amino acids

Ambiguity of the effect of high and low doses of amino-acid preparations on the immune response and phagocytosis in mice

Wound healing: time to look for intelligent, ‘natural’ immunological approaches?

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