Peptides as a therapeutic avenue for nanocarrier-aided targeting of glioma

Abstract

Very few successful interventions have been possible in glioma therapy owing to its aggressive nature as well as its hindrance of targeted therapy together with the limited access afforded by the blood-brain barrier (BBB). With the advent of nanotechnology based delivery vehicles such as micelles, dendrimers, polymer-based nanoparticles and nanogels, the breach of the BBB has been facilitated. However, there remains the issue of targeted therapy for glioma cells. Peptide-mediated surface modification of nanocarriers serves this purpose, extending the ability to target glioma further than the enhanced permeability and retention effect. Areas covered: Here we have tried to re-establish the significance of peptides that could be used in various ways for treating glioma. Peptide-embellished nanocarriers used to deliver anticancer drugs; nucleic acids (siRNA, miRNA); micelles or dendrimers grafted with immunogenic glioma-derived peptides used for stimulating active immunity in vaccine therapy, glioma targets for cell penetrating peptides and homing to specific receptors are reviewed. Expert opinion: Peptides have multifunctional potential in targeting, BBB and cell penetration, and can serve as antagonists of various ligands and agonists of particular over-expressed receptors as discussed in this review. Using peptides in targeted personalized therapy would be one step forward and may offer new avenues for glioma therapeutics.

Near infrared light fluorescence imaging-guided biomimetic nanoparticles of extracellular vesicles deliver indocyanine green and paclitaxel for hyperthermia combined with chemotherapy against glioma

“…The promising advantages of low immunogenicity, intrinsic cell targeting properties, and enhanced stability in circulation make EVs an ever more attractive concept in targeted drug therapy, and highlight their potential in the therapy of various diseases, including glioma [ 12 ]. Recently, cell penetrating peptides have emerged as a critical player in targeted therapy for glioma by embellishing nanocarriers to deliver anti-tumor drugs [ 18 ]. During the current investigation, we aimed to explore the therapeutic effect of ICG/PTX transferred by RGE-EV in glioma.…”

Current Strategies for Brain Drug Delivery

“…Coating cell permeable peptides on the surface of nanoparticles could serve this purpose. A detailed review about peptides for targeting glioma cells can be found 17 . This review mainly focuses on crossing the BBTB.…”

Current Strategies to Enhance Delivery of Drugs across the Blood–Brain Barrier

“…Coating cell-permeable peptides might accomplish this on the surface of nanoparticles. A comprehensive review of peptides for glioma cell targeting may be obtained [ 33 ]. This review is mostly concerned with crossing the BBTB.…”