2020
DOI: 10.17116/profmed202023062105
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Peptides mimicking the spatial structure of erythropoietin α-chain B — new possibilities for the treatment and prevention of hyperhomocysteine-induced endothelial dysfunction

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“…Erythropoietin short-chain derivatives, the classic example of which is pHBPS, are most promising in this regard (Brines et al 2015;Xiong et al 2015;Korokin et al 2020a). The possibility to give them additional properties by modifying the polypeptide chain, in particular, the antiplatelet activity with the cytoprotective activity remaining at the same level, is of major importance (Golubev et al 2020b;Gureev et al 2020;Korokin et al 2020b;Puchenkova et al 2020). For the study, we selected a polypeptide EP-11-1 (UEHLERALNSS), which has antiplatelet and cytoprotective activities (Antsiferov et al 2020;Korokin et al 2020c;Korokin et al 2021).…”
Section: Introductionmentioning
confidence: 99%
“…Erythropoietin short-chain derivatives, the classic example of which is pHBPS, are most promising in this regard (Brines et al 2015;Xiong et al 2015;Korokin et al 2020a). The possibility to give them additional properties by modifying the polypeptide chain, in particular, the antiplatelet activity with the cytoprotective activity remaining at the same level, is of major importance (Golubev et al 2020b;Gureev et al 2020;Korokin et al 2020b;Puchenkova et al 2020). For the study, we selected a polypeptide EP-11-1 (UEHLERALNSS), which has antiplatelet and cytoprotective activities (Antsiferov et al 2020;Korokin et al 2020c;Korokin et al 2021).…”
Section: Introductionmentioning
confidence: 99%