Pequi (Caryocar brasiliense Camb.) almond oil attenuates carbon tetrachloride-induced acute hepatic injury in rats: Antioxidant and anti-inflammatory effects

Tôrres, Lucillia Rabelo de Oliveira; Santana, Fernanda; Leal, Francisco; Melo, Illana Louise Pereira de; Yoshime, Luciana Tedesco; Matos-Neto, Emídio Marques de; Seelaender, Marília; Araújo, Cintia Maria Monteiro de; Cogliati, Bruno; Mancini‐Filho, Jorge

doi:10.1016/j.fct.2016.09.009

Cited by 82 publications

(72 citation statements)

References 41 publications

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“…Miranda-Vilela et al (2009b) reported that C. brasiliense pulp oil produced anti-inflammatory effects in athlete runners who were supplemented with 400 mg of oil after races for 14 days, which led to a higher reduction in the values of high-sensitivity C-reactive protein (hs-CRP), an acute-phase reactant and a sign of inflammation, implying that inflammation decreased. These findings are in agreement with those found using C. brasiliense almond oil, in which there was a decrease in inflammation in the serum and hepatic tissue of rats induced by carbon tetrachloride (CCl 4 ) (Torres et al, 2016a).…”

Section: Anti-inflammatory Activitysupporting

confidence: 83%

“…The exact mechanism of anti-inflammatory action is still subject of debate; however, these effects may correlate with the properties of carotenoids and FA, such as oleic acid, present in the Caryocar spp., probably by reducing the concentration and expression of inflammatory mediators at protein and genomic levels via the production of anti-inflammatory eicosanoids, inhibition of cyclooxygenase (COX) and lipoxygenase (LOX) enzymes, or by the improvement of the antioxidant defense system (Yamaguchi et al, 2017;Torres et al, 2016a;De Oliveira et al, 2015;Saraiva et al, 2011b;De Oliveira et al, 2010;Miranda-Vilela et al, 2009b;Da Silva Quirino et al, 2009). …”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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Bioactive compounds and functional potential of pequi (<em>Caryocar</em> spp.), a native Brazilian fruit: a review

et al. 2018

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SUMMARY:Pequi is an indigenous word that means "thorny covering" and is used to describe fruits from the Caryocar spp. These fruits are widely consumed as food and used in traditional medicine by Brazilians in the savannah (Cerrado biome) and the Amazon region. The fruit is rich in lipids, mainly oleic acid, and other bioactive substances including carotenoids, phenolics, and tocopherols. The oil extracted from the pulp or "almond" (seed) has a high local socioeconomic impact and is associated with nutritional and therapeutic benefits. A wide array of health benefits such as antioxidant, anti-inflammatory, antitumor, and antimicrobial effects, improved cardiac function, as well as an increased lymphocyte-dependent immunity have been attributed to the pequi fruit, especially its pulp. This review provides a comprehensive overview on the edible parts of pequi fruits (pulp and almond), more specifically the oil produced from these parts, as a source of functional compounds with biological activity. Moreover, it considers the differences among the three more commercially-important species from the genus Caryocar. KEYWORDS: Bioactive compounds; Caryocaraceae; Fruit; Health benefits; Oleic acid RESUMEN:Compuestos bioactivos y funcionalidad potencial del pequi (Caryocar spp.), fruta nativa brasileña. Revisión. Pequi es una palabra indígena que significa "piel espinosa" y es utilizada para describir los frutos de Caryocar spp. Estos frutos son ampliamente consumidos como alimentos y son utilizados en la medicina popular por los brasileños ubicados en el Savannah (bioma Cerrado) y en la región amazónica. La fruta es rica en grasas, ácido oleico y otros bioactivos, incluyendo carotenoides, fenoles y tocoferoles. El aceite procedente de la pulpa o de la almendra (semilla) tiene un importante impacto socioeconómico local y está asociado con beneficios nutricionales y terapéuticos. Una amplia gama de beneficios para la salud tales como antioxidante, antiinflamatorio, antitumoral, antimicrobiano, mejora de la función cardíaca, así como el aumento de la inmunidad linfocitaria han sido atribuidas a la fruta, especialmente a su pulpa. Esta revisión proporciona una descripción exhaustiva sobre las partes comestibles de la fruta del pequi (pulpa y almendra), más específicamente del aceite producido a partir de estas partes, como una fuente de compuestos funcionales con actividad biológica. Además se consideran las diferencias encontradas entre las tres especies comerciales más importantes del género Caryocar.

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Section: Anti-inflammatory Activitysupporting

confidence: 83%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Bioactive compounds and functional potential of pequi (<em>Caryocar</em> spp.), a native Brazilian fruit: a review

et al. 2018

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“…The liver metabolism of CCl 4 releases high amounts of ROS, leading to apoptosis, autophagy, inflammation and tissue necrosis . Caspase‐3 is the central effector of apoptosis, and it is used as a reliable indicator to determine the apoptosis severity .…”

Section: Resultsmentioning

confidence: 99%

Brassica rapa Polysaccharides Ameliorate CCl₄‐Induced Acute Liver Injury in Mice through Inhibiting Inflammatory Apoptotic Response and Oxidative Stress

Yang

Wang

et al. 2019

Chemistry & Biodiversity

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Brassica rapa L., also called NIUMA, is used empirically in Tibetan medicine for its antioxidant, antiinflammatory and antiradiation activities. This study explored the hepatoprotective effects of B. rapa polysaccharides (BRPs) on acute liver injury induced by carbon tetrachloride (CCl 4 ) in mice and the underlying mechanisms. Mice were treated with CCl 4 after the oral administration of BRPs (55, 110 and 220 mg/kg) or bifendate (100 mg/kg) for 7 days. Blood and liver samples of mice were collected for analysis after 24 h. The ALP, ALT and AST levels and the biological activities of SOD, MDA and GSHÀ Px were measured. Histopathological changes in the liver were determined through hematoxylin and eosin staining. Moreover, TNF-α, IL-1β and IL-6 expression levels were detected by commercial reagent kits. Finally, Western blot analysis was used to check the relative expression levels of caspase-3, p-JAK2 and p-STAT3. The BRP pre-treatment significantly decreased the enzymatic activities of ALT, ALP and AST in the serum, markedly increased the activities of SOD and GSHÀ Px in the liver and reduced the MDA concentration in the liver. BRPs alleviated hepatocyte injury and markedly inhibited the expression of TNF-α, IL-1β and IL-6, also downregulating the CCl 4 -induced hepatic tissue expression of caspase-3. Furthermore, BRPs inhibited the JAK2/STAT3 signaling pathway in a dose-dependent manner in the liver. This study demonstrated that BRPs exert hepatoprotective effect against the CCl 4 -induced liver injury via modulating the apoptotic and inflammatory responses and downregulating the JAK2/STAT3 signaling pathway. Therefore, B. rapa could be considered a hepatoprotective medicine.

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“…O óleo da amêndoa apresenta elevado teor de ácidos graxos poli-insaturados e ácidos graxos essenciais (ω-3 e ω-6), além de compostos bioativos com efeito benéfico sobre indução do processo oxidativo desencadeado por radicais livres, proteção hepatotóxica e ação anti-inflamatória, conforme relatado por Torres et al (2016).…”

Section: Pequiunclassified

Características e potencialidades dos frutos do Cerrado na indústria de alimentos

Reis

Schmiele

2019

Braz. J. Food Technol.

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Resumo O Cerrado é o segundo maior bioma brasileiro e apresenta grande diversidade de frutos que possuem alto valor nutricional, sabor e aroma característicos, compostos bioativos com propriedades antioxidantes e apelo saudável. O mercado consumidor visa a produtos com apelo natural e funcional, e, pelo fato de haver grandes perdas pós-colheita dos frutos do cerrado, cabe à indústria de alimentos aliar tais propriedades dos frutos à elaboração de novos produtos com valor agregado e maior tempo de vida de prateleira. O presente trabalho apresenta uma revisão com o objetivo de listar e caracterizar os frutos do cerrado (pequi, bocaiuva, mangaba, cagaita, baru, murici, mama-cadela, buriti, araticum e guabiroba), apresentando estudos com possíveis aplicações na indústria de alimentos.

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Pequi (Caryocar brasiliense Camb.) almond oil attenuates carbon tetrachloride-induced acute hepatic injury in rats: Antioxidant and anti-inflammatory effects

Cited by 82 publications

References 41 publications

Bioactive compounds and functional potential of pequi (<em>Caryocar</em> spp.), a native Brazilian fruit: a review

Bioactive compounds and functional potential of pequi (<em>Caryocar</em> spp.), a native Brazilian fruit: a review

Brassica rapa Polysaccharides Ameliorate CCl₄‐Induced Acute Liver Injury in Mice through Inhibiting Inflammatory Apoptotic Response and Oxidative Stress

Características e potencialidades dos frutos do Cerrado na indústria de alimentos

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Pequi (Caryocar brasiliense Camb.) almond oil attenuates carbon tetrachloride-induced acute hepatic injury in rats: Antioxidant and anti-inflammatory effects

Cited by 82 publications

References 41 publications

Bioactive compounds and functional potential of pequi (<em>Caryocar</em> spp.), a native Brazilian fruit: a review

Bioactive compounds and functional potential of pequi (<em>Caryocar</em> spp.), a native Brazilian fruit: a review

Brassica rapa Polysaccharides Ameliorate CCl4‐Induced Acute Liver Injury in Mice through Inhibiting Inflammatory Apoptotic Response and Oxidative Stress

Características e potencialidades dos frutos do Cerrado na indústria de alimentos

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Product

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Brassica rapa Polysaccharides Ameliorate CCl₄‐Induced Acute Liver Injury in Mice through Inhibiting Inflammatory Apoptotic Response and Oxidative Stress