Per- and polyfluoroalkyl substances (PFASs) modify lung surfactant function and pro-inflammatory responses in human bronchial epithelial cells

Sørli, Jorid B.; Låg, Marit; Ekeren, Leni; Pérez‐Gil, Jesús; Haug, Line Småstuen; Silva, Emilie Da; Matrod, Muhammad N.; Gützkow, Kristine B.; Lindeman, Birgitte

doi:10.1016/j.tiv.2019.104656

Cited by 70 publications

(38 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A camera continuously takes pictures of the droplet before and during exposure to aerosols of the test substance at the air–liquid interface. Alternatively, the lung surfactant and the test substance can be mixed prior to deposition on the pedestal ( Sørli et al, 2020 ). Surface tension values are obtained by analysis of the drop shape in real-time ( Yu et al, 2016 ).…”

Section: Technical Details and Methodologiesmentioning

confidence: 99%

“…The main advantages of this method include the accessibility of the air–liquid interface for exposure to airborne substances, flexibility in controlling cycling rates, and ease of determination of the surface tension in real-time while cycling the surfactant film. The constrained drop surfactometer has been applied to the exposure to a broad range of substances, including nanoparticles ( Larsen et al, 2020 , Valle et al, 2015 , Fan et al, 2011 , Yang et al, 2018 , Wang et al, 2020 ), individual chemicals ( Da Silva et al, 2021 ), mixtures of chemicals ( Da Silva, et al, 2021 , Sørli et al, 2018 , Sørli et al, 2016 ), excipients for drug formulation ( Sørli et al, 2018 ), per- and poly-fluoroalkyl substances ( Sørli et al, 2020 ), or plasma ( Autilio et al, 2021 ).…”

Section: Technical Details and Methodologiesmentioning

confidence: 99%

See 1 more Smart Citation

An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function

Silva

Vogel

Hougaard

et al. 2021

Current Research in Toxicology

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Technical Details and Methodologiesmentioning

confidence: 99%

Section: Technical Details and Methodologiesmentioning

confidence: 99%

An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function

Silva

Vogel

Hougaard

et al. 2021

Current Research in Toxicology

Self Cite

View full text Add to dashboard Cite

show abstract

“…PFOA can also alter T cell profiles and expression of proinflammatory cytokines in the spleen of mice [116], and PFOS, PFOA and PFDA induced the release of inflammatory cytokines in cells [117,118]. In human bronchial epithelial cells, proinflammatory cytokine release resulted following exposure to PFOA and PFOS but not PFBS, PFHxS and the fluorotelomer 8:2 FTOH [119]. Interestingly, inflammation may mediate PFAS transfer across the blood cerebrospinal fluid barrier in humans through enhanced barrier permeability [120].…”

Section: Induces Chronic Inflammationmentioning

confidence: 99%

“…PFOA Association: [105]; [106]; [107]; [108]; [110]; [112] No association: [109] Association: [115]; [116] Association: [90]; [117] Long-chain PFAS a PFOS Association: [110] No association: [107]; [113] Association: [114] Association: [117]; [119] PFHxS…”

Section: Epidemiological Animal Bioassay In Vitromentioning

confidence: 99%

Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

Temkin

Hocevar

Andrews

et al. 2020

IJERPH

View full text Add to dashboard Cite

Per- and polyfluoroalkyl substances (PFAS) constitute a large class of environmentally persistent chemicals used in industrial and consumer products. Human exposure to PFAS is extensive, and PFAS contamination has been reported in drinking water and food supplies as well as in the serum of nearly all people. The most well-studied member of the PFAS class, perfluorooctanoic acid (PFOA), induces tumors in animal bioassays and has been associated with elevated risk of cancer in human populations. GenX, one of the PFOA replacement chemicals, induces tumors in animal bioassays as well. Using the Key Characteristics of Carcinogens framework for cancer hazard identification, we considered the existing epidemiological, toxicological and mechanistic data for 26 different PFAS. We found strong evidence that multiple PFAS induce oxidative stress, are immunosuppressive, and modulate receptor-mediated effects. We also found suggestive evidence indicating that some PFAS can induce epigenetic alterations and influence cell proliferation. Experimental data indicate that PFAS are not genotoxic and generally do not undergo metabolic activation. Data are currently insufficient to assess whether any PFAS promote chronic inflammation, cellular immortalization or alter DNA repair. While more research is needed to address data gaps, evidence exists that several PFAS exhibit one or more of the key characteristics of carcinogens.

show abstract

“…A further consequence of its low surface tension is the formation of micelles at higher concentrations. The critical micelle concentration (CMC) for PFOS and PFOA has been cited as 3500 mg/L and 5800 mg/L, respectively [129]. It has been hypothesized that the formation of micelles could enhance adsorption onto carbon and other minerals while blocking diffusion into the inner surface of the adsorbent [130].…”

Section: Aqueous Transportmentioning

confidence: 99%

A Review of the Applications, Environmental Release, and Remediation Technologies of Per- and Polyfluoroalkyl Substances

Meegoda

Kewalramani

et al. 2020

IJERPH

123

View full text Add to dashboard Cite

Per- and polyfluoroalkyl substances (PFAS) are pollutants that have demonstrated a high level of environmental persistence and are very difficult to remediate. As the body of literature on their environmental effects has increased, so has regulatory and research scrutiny. The widespread usage of PFAS in industrial applications and consumer products, complicated by their environmental release, mobility, fate, and transport, have resulted in multiple exposure routes for humans. Furthermore, low screening levels and stringent regulatory standards that vary by state introduce considerable uncertainty and potential costs in the environmental management of PFAS. The recalcitrant nature of PFAS render their removal difficult, but existing and emerging technologies can be leveraged to destroy or sequester PFAS in a variety of environmental matrices. Additionally, new research on PFAS remediation technologies has emerged to address the efficiency, costs, and other shortcomings of existing remediation methods. Further research on the impact of field parameters such as secondary water quality effects, the presence of co-contaminants and emerging PFAS, reaction mechanisms, defluorination yields, and the decomposition products of treatment technologies is needed to fully evaluate these emerging technologies, and industry attention should focus on treatment train approaches to improve efficiency and reduce the cost of treatment.

show abstract

Per- and polyfluoroalkyl substances (PFASs) modify lung surfactant function and pro-inflammatory responses in human bronchial epithelial cells

Cited by 70 publications

References 62 publications

An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function

An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function

Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

A Review of the Applications, Environmental Release, and Remediation Technologies of Per- and Polyfluoroalkyl Substances

Contact Info

Product

Resources

About