This research was conducted at small and medium businesses, namely PT Sumber Karya Indah, a company engaged in the manufacture of women’s bags. There are 10 activities in the process of producing women’s bags. This work system is analyzed using the Nordic Body Map (NBM) method, Rapid Whole Body Assessment (REBA), Work Risk Ergonomic Risk Assessment (WERA), and Biomechanics to see ergonomic risks. The results of the Nordic Body Map questionnaire after working compared to before showed that there were 6 parts of the body of workers that had the highest value, namely the upper neck, buttocks, waist, right hand, left thigh and right thigh. REBA and WERA analysis was carried out on 10 activities to find potentially problematic activities to work health and comfort. The results of the analysis showed that there were 2 activities with high categories of REBA analysis methods, gluing activities (with a score of 10) and sticking activities (with a score of 9). Based on the WERA analysis, the two activities also showed the 2 highest values in the medium category, each with a value of 36 and 34. While the Biomechanical Analysis of worker posture on the gluing activity obtained a thigh muscle pressure score of2440 N and the overall moment was 248 NM towards the left. For sticking activity, the score for the thigh muscle was 1974.2 N and the overall moment was 63.2 NM to the left. Based on the results of these four analyzes, it can be concluded that sticking and sticking activities require immediate ergonomic intervention to reduce occupational health risks.