Perbandingan Carbomer dan CMC-Na Sebagai Gelling Agent Pada Formulasi Hand Sanitizer Aloe Vera

Mochtar, Muhammad; Nasyanka, Anindi; Tiadeka, Pemta

doi:10.56399/jst.v2i2.23

Cited by 4 publications

(6 citation statements)

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“…As more Carbopol 934 is added, the viscosity increases, and vice versa. The increase in viscosity during storage can be caused by the expansion of the polymer in the gel preparation and increases the bond density between polymers [ 26 , 27 ]. Our study used 1% Carbopol 934 as a gelling agent, although there were significant differences when compared to several commercial preparations, which showed good stability in physical properties and still met the requirements [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

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Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract

Wahyuni,

Sufiawati,

Shafuria

et al. 2024

Pharmaceutics

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The rhizome of Kaempferia galanga (Zingiberaceae) is extensively used in traditional medicine by utilizing its various biological activities. It has been proven that ethyl-para-methoxycinnamate (EPMC) and other polyphenolic compounds are present in considerable amounts in the ethanolic extract of K. galanga rhizome (EKG). Our previous study confirmed that a dose of 0.5–1% of EKG demonstrated anti-inflammatory activity and a wound-healing effect in chemical-induced oral mucosal ulcers of Wistar rats. Currently, there are no reports on the formulation of oral gel containing EKG, thus revealing the potential of EKG to be developed as a herbal oral gel for mucosal ulcers. This study aims to formulate the best mucoadhesive oral care gel containing EKG in terms of physical stability. The presence of EPMC and the total phenols in the best EKG gel were also determined. The results revealed that Carbopol 934 is the best gelling agent for EKG gel preparations as proven by its stability during 14 days of storage. The statistical analysis resulted in a significant difference between the physical stability of the Carbopol 934-based EKG gel preparation compared to three commercial oral care gel products (p < 0.05). RP-HPLC chromatograms indicated that EPMC was identified in Carbopol 934-based gels containing 5% and 10% EKG at 6.056 and 6.146 min, respectively, with polyphenol levels of 1201.2557 mg/kg and 1849.1506 mg/kg, respectively. The hedonic test performed on 30 respondents to measure the degree of consumer acceptance and satisfaction confirmed that 5% EKG gel is the most sensorially accepted by the respondents. Data were analyzed using paired t-tests, one-way ANOVA, and a Kruskal–Wallis test. Taken together, the Carbopol 934-based gel containing 5% EKG could potentially be further developed as a topical anti-oral mucosal ulcer drug for clinical purposes.

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Section: Discussionmentioning

confidence: 99%

“…A gelling agent will form a structural network which is an important factor in the gel system. Humectants will maintain the stability of the gel preparation by absorbing moisture from the environment and reducing water evaporation from the preparation [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract

Wahyuni,

Sufiawati,

Shafuria

et al. 2024

Pharmaceutics

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“…Panjang gelombang maksimum tersebut yang digunakan untuk mengukur serapan dari sampel gel ekstrak mesokarp buah semangka (Citrullus lanatus). Larutan standar pada penelitian ini menggunakan larutan standar kuersetin dengan konsentrasi 100 ppm, kemudian dilakukan pengenceran dengan berbagai konsentrasi yaitu 0, 6,8,10,12,14 Hasil penetapan kadar flavonoid total gel ekstrak mesokarp buah semangka diketahui kadar rata-rata flavonoid total sebesar 5,27%. Hal ini sejalan dengan penelitian, yang menunjukkan bahwa senyawa flavonoid yang terkandung dalam buah semangka mempunyai kandungan sebesar 0,003% (28) .…”

Section: Tabel 2 Hasil Uji Organoleptik Sediaan Gel Ekstrak Mesokarp ...unclassified

“…Carbopol dapat menjadi gelling agent dengan hanya konsentrasi kecil 1-2% (11) . Suatu penelitian menunjukkan formula Carbopol yang dibutuhkan hanya 0,3%, sedangkan Na-CMC lebih banyak yaitu 3,5%, hasil uji pH juga menunjukkan dengan carbopol pH sediaan tidak berubah setelah penyimpanan 8 hari (12) . Latar belakang tersebut mendasari penelitian ini dilakukan dengan tujuan untuk mengetahui hasil evaluasi stabilitas fisik gel ekstrak mesokarp buah semangka (Citrullus lanatus) dan mengetahui kadar flavonoid total.…”

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Physical Stability Test and Determination of Total Flavonoid Content of Watermelon (Citrullus lanatus) Fruit Mesocarp Extract Gel Preparation

Dewi¹,

Atikah

Putri

2022

jifi

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The content of flavonoids in the white skin or mesocarp of watermelon has antioxidant power so that the active substance can be used in the manufacture of cosmetics, one of which is a gel dosage form. This type of research is observational with a descriptive research design. The purpose of this study was to obtain data on the stability of the watermelon (Citrullus lanatus) mesocarp extract gel preparation using the cycling test method. Physical stability evaluations were carried out, including organoleptic, homogeneity, pH, adhesion, spreadability, and viscosity. The results showed that the organoleptic observation of the preparation was in the form of a semi-solid, had a characteristic aromatic odor of the extract, and had a brownish-yellow color. As for the test results for the entire homogeneous cycle, the average pH range is 4.75 - 5, adhesion is 2.45 - 3.96 seconds, dispersion is 5.59 - 6.67 cm, and viscosity is 5426 - 6830 cps, and total flavonoid content of the gel preparation was 5.27%. This study concluded that the gel preparation was physically stable before and after 12 days of storage and contained 5.27% flavonoids.

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“…Focusing on their role, the two ingredients are considered to have the most dominant influence on the physical characteristics of hand sanitizer gel preparations. CMC-Na as a gelling agent has advantages because it is able to create more stable preparations, the appearance of the gel is clearer, and not sticky [10]. Hand sanitizers are composed of various chemical compounds, so the role of glycerin as a vehicle in aqueous solution is needed to unite all the components in it.…”

Section: Introductionmentioning

confidence: 99%

Optimization of The Combination of CMC-Na and Glycerin in Tobacco (Nicotiana tabacum L.) Hand Sanitizer Gel Using The Simplex Lattice Design

et al. 2023

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Tobacco leaves have active compounds such as phenols and alkaloids that can be used as antibacterial and antiseptic because they can damage the cell components of microorganisms. Tobacco leaf extract in hand sanitizer gel has been shown to have antibacterial activity against Staphylococcus aureus and Eschericia coli bacteria at a minimum concentration of 0.25%. Hand sanitizer is an antiseptic product that is used to clean hands and is preferred because it is practical, has a cooling and dries quickly when compared to hand soap. To make hand sanitizer products that are safe for the skin, various chemical compounds are used as building blocks, including CMC-Na and glycerin. CMC-Na acts as a gelling agent and glycerin has a role as a vehicle. This study aims to obtain the optimum formula for hand sanitizer gel preparations with variations in the concentration ratio of CMC-Na and glycerin using Simplex Lattice Design (SLD) and to determine the effect of variations in the concentration ratio of CMC-Na and glycerin on physical, chemical, and microbiological characteristics of the results of the optimum formula for hand sanitizer gel preparations. The research method used in this study is a type of laboratory experiment using Completely Randomized Design (CRD). The data obtained from the research results were processed using Analysis of Variance (ANOVA) with a 95% confidence level and continued with Duncan's Multiple Range Test at a significance level of 5%. The results showed that there were 3 optimum formulas for hand sanitizer gel of tobacco leaf extract based on the desirability value, 0.912 (Formula 1), 0.457 (Formula 4) and 0.653 (Formula 5). The variation of the concentration ratio of CMC-Na and glycerin in the optimum formula showed that CMC-Na had the most dominant influence on physical (homogeneity), chemical (total flavonoid) and microbiological (antibacterial and antiseptic) characteristics. Meanwhile, glycerin has the most dominant influence on product viscosity stability. The three optimum formulas have homogeneous gel characteristics.

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Perbandingan Carbomer dan CMC-Na Sebagai Gelling Agent Pada Formulasi Hand Sanitizer Aloe Vera

Cited by 4 publications

References 0 publications

Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract

Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract

Physical Stability Test and Determination of Total Flavonoid Content of Watermelon (Citrullus lanatus) Fruit Mesocarp Extract Gel Preparation

Optimization of The Combination of CMC-Na and Glycerin in Tobacco (Nicotiana tabacum L.) Hand Sanitizer Gel Using The Simplex Lattice Design

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