Perbedaan Ekspresi Vascular Endothelial Growth Factor dan Ekspresi Tissue Factor Berdasarkan Respons Terapi Kemoradiasi Cisplatin pada Penderita Karsinoma Nasofaring Stadium lanjut

Hendarsih, Een; Oehadian, Amaylia; Sumantri, Rachmat; Supandiman, Iman; Hernowo, Bethy S.

doi:10.15395/mkb.v47n1.397

Cited by 5 publications

(4 citation statements)

References 8 publications

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Section: Discussionmentioning

confidence: 99%

The Role of Cyclin D1 and VEGF in Radiotherapy Response of Advance Stage Undifferentiated Nasopharyngeal Carcinoma

Nurhidayat¹,

Afiati²,

Usman³

et al. 2020

FMI

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Nasopharyngeal carcinoma has a high incidence and mortality rate in Southeast Asia and Indonesia. Radioresistance is a major obstacle to successful treatment of nasopharyngeal carcinoma. DNA repair in the cell cycle and angiogenesis factors affects the response of tumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and VEGF as an angiogenesis factor are considered to play a role in the occurrence of radioresistance. The objective of this study is to find the association between immunoexpression of Cyclin D1 and VEGF with radiotherapy response in undifferentiated nasopharyngeal carcinoma. This study used a retrospective case control analysis design, secondary data from medical records of patients diagnosed as undifferentiated nasopharyngeal carcinoma who received complete radiotherapy at the Radiation Oncology Department, Dr. Hasan Sadikin Bandung were taken. There were 44 samples divided into radiosensitive (22 samples) and radioresistant (22 samples) groups. Immunohistochemical examination of Cyclin D1 and VEGF was performed on paraffin blocks of patients' biopsy. Data analysis using Chi-Square test (p≤0.05) , OR 95% CI. Cyclin D1 expressed strongly in 86.4% of the radioresistant group and 59.1% in the radiosensitive group (p<0.05) and the OR 4,385 (0.993-19.356), VEGF was strongly expressed in 77.3% of the radioresistant group and 54.5% in the radiosensitive group (p>0.05). As conclusion, there were significant association between Cyclin D1 with radiotherapy respons in undifferentiated nasopharyngeal carcinoma. The stronger immunoexpression of Cyclin D1, the higher likelihood of radioresistancy. VEGF immunoexpression showed no significant association with radiotherapy response.

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Section: Discussionmentioning

confidence: 99%

The Role of Cyclin D1 and VEGF in Radiotherapy Response of Advance Stage Undifferentiated Nasopharyngeal Carcinoma

Nurhidayat¹,

Afiati²,

Usman³

et al. 2020

FMI

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“…Previous studies also reported a significant relationship between the degree of VEGF expression and NPC stage. They also noted that VEGF detection in NPC tissue might be useful for calculating limfe gland metastases and recurrence, assessing clinical stage, and evaluating the prognosis of NPC [14,15].…”

Section: Discussionmentioning

confidence: 99%

Overexpression Vascular Endothelial Growth Factor in Nasopharyngeal Carcinoma With Undifferentiated Carcinoma Type in Advanced Stage

Aryana¹

2019

IJNPC

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Introduction: Nasopharyngeal Carcinoma (NPC) is a malignancy that tends to diagnosed at an advanced stage with low survival and prognosis rate. One of the factors that may play a role in progressivity and metastasis of tumor is overexpression of vascular endothelial growth factor (VEGF), which is a key role in tumor angiogenesis. Objective: This study aims to learn the expression of VEGF in NPC with Undifferentiated Carcinoma type and to learn the association pf VEGF Expression with tumor stage of NPC Method: This is a cross-sectional study performed in ENT-HNS Department of ENT-HNS of Udayana University/Sanglah Hospital. The sample was collected by consecutive nonprobability sampling, starting from January 2016. NPC patients underwent Histopathologic examination from a nasopharyngeal biopsy. The result is Undifferentiated Carcinoma. VEGF expression analyzed by red-brown stained cytoplasm. Data were analyzed by Spearman's Correlation Test Chi-Square test, and Paired Sample t-Test. Result: VEGF positive Expression was found in 27 of 28 (96.4%) Undifferentiated Carcinoma type of NPC cases. VEGF overexpression was found in 23 of 28 (82.4%) Undifferentiated Carcinoma type of NPC cases.There is significant correlation found between tumor stage and VEGF expression (p<0.05). Conclusion: From the research, it could conclude that there is significant correlation between tumor stage and VEGF Expression.

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“…It was explained that in nasopharyngeal carcinoma, the oxygen factor alone is not sufficient to predict radiosensitivity, there are many other biological factors that involve in radiosensitivity. 19 Moreover, the amount of angiogenic factors influence the pathway of radioresistance. Tumor cells with a few angiogenic factors will become radioresistence via hypoxic pathways, whereas tumor cells that have much of angiogenic factors will become radioresistance through intrinsic pathways and ischemic factors.…”

Section: Discussionmentioning

confidence: 99%

The role of cyclin D1 and vascular endothelial growth factor (VEGF) in radiotherapy response of undifferentiated nasopharyngeal carcinoma

Nurhidayat¹,

Afiati²,

Usman³

et al. 2018

JMedScie

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Nasopharyngeal carcinoma (NPC) has a high incidence and mortality rate in Southeast Asia included in Indonesia. Radioresistance is a major obstacle for a successful treatment of NPC. DNA repair in the cell cycle and angiogenesis factors affect the response of tumor cells to radiotherapy. Cyclin D1 that functions in the cell cycle process and vascular endothelial growth factor (VEGF) as an angiogenesis factor are considered to play a role in the occurrence of radioresistance. The objective of this study was to evaluate the association between cyclin D1 and VEGF expressions with radiotherapy response in undifferentiated NPC. This study used a retrospective case control analysis design. Secondary data from medical records of patients diagnosed as undifferentiated NPC who received a complete radiotherapy at the Department of Radiation Oncology, Dr. Hasan Sadikin General Hospital, Bandung. There were 44 samples divided into radiosensitive (22 samples) and radioresistant (22 samples) groups. Immunohistochemical examination of cyclin D1 and VEGF expressions was performed on paraffin blocks of patients' nasopharyngeal biopsy. Data analysis used Chi-Square test with p ≤0.05. Cyclin D1 was expressed strongly in 86.4% of the radioresistant group and 59.1% in the radiosensitive group (p<0.05), VEGF was strongly expressed in 77.3% of the radioresistant group and 54.5% in the radiosensitive group (p>0.05). In conclusion, there is significant association between cyclin D1 expression with radiotherapy response in undifferentiated NPC. However, there is no association between VEGF expression with radiotherapy response.

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Perbedaan Ekspresi Vascular Endothelial Growth Factor dan Ekspresi Tissue Factor Berdasarkan Respons Terapi Kemoradiasi Cisplatin pada Penderita Karsinoma Nasofaring Stadium lanjut

Cited by 5 publications

References 8 publications

The Role of Cyclin D1 and VEGF in Radiotherapy Response of Advance Stage Undifferentiated Nasopharyngeal Carcinoma

The Role of Cyclin D1 and VEGF in Radiotherapy Response of Advance Stage Undifferentiated Nasopharyngeal Carcinoma

Overexpression Vascular Endothelial Growth Factor in Nasopharyngeal Carcinoma With Undifferentiated Carcinoma Type in Advanced Stage

The role of cyclin D1 and vascular endothelial growth factor (VEGF) in radiotherapy response of undifferentiated nasopharyngeal carcinoma

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