This research is motivated by the influence of high technology on education; hence educators need to choose the right technology device to use and compare student learning interests with and without the support of computer and android multimedia. It was quasi-experiment research with posttest only and non-equivalent control group designs. The subjects of this research were the eleventh-grade students of Natural Science. There were 2 sample classes-the eleventh-grade students of Natural Science 3 (experiment I) taught using computer multimedia, and the students of Natural Science 1 (experiment II) taught using android multimedia. Interview with teachers, preliminary data test that was homogeneity test, final data test, learning interest questionnaire, interview, observation, and documentation were used to collect the data. The analysis result showed that the learning interest percentage of experiment I was 73.88% with the high category, and experiment II was 81.19% with the very high category. An independent t-test was used to see whether there was a significant difference between experiments I and II. It showed a significant difference in chemistry learning interest between students taught by using computerbased multimedia and those taught by using android-based multimedia on the acid-based lesson of chemistry subject at the eleventh grade of Natural Science. Therefore, Android-based learning could be developed in the learning process to support student chemistry learning interests.