“…For meta-analyses five and six, GRADE analysis revealed that the true effect is likely to be substantially different from the estimate of effect (very low confidence). Most (68%) 4,6,26,[33][34][35][39][40][41][42][43]45,46,[50][51][52][53][54][55]56,57, of the included studies incorporated low risk for selection bias, with the remaining studies presenting selection bias that was non-applicable (10%), 36, unclear (16%), 37,[47][48][49]118,[127][128][129][130][131][132] or, in some cases, high risk (6%) 5,38,44,133 due to acrossgroup variation in inclusion or exclusion criteria, and across-group differences in participant recruitment or selection. Most (61%) of the included studies incorporated low risk for confounding factors bias, with the remaining studies presenting confounding factor bias that was unclear (16%) 6 ,26,36,38,60,62,63,67,80,84,85,92,98-100,102,105,107-111,113,114,134-136 or high risk (23%) 33 ,35,37,44,45,47,49,59,66,74,83,86,89,91,94,96,118,127,128,132…”