Perceived odor, irritation, and health symptoms following short-term exposure to acetone

Dalton, Pamela; Wysocki, Charles J.; Brody, Michael J.; Lawley, Henry J.

doi:10.1002/(sici)1097-0274(199705)31:5<558::aid-ajim10>3.0.co;2-y

Cited by 86 publications

(43 citation statements)

References 33 publications

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“…These changes were not observed for butanol. 5,139 Similarly, the isopropanol irritation thresholds of phlebotomists who were regularly exposed to isopropanol in the workplace were elevated, but their irritant thresholds for butanol did not differ from unexposed, naïve controls. 197 Cross-adaptation, defined as a decrease in sensitivity (or perceived intensity) to one chemical after exposure to a different chemical, has been interpreted, in the case of olfaction, as a measure of the degree to which stimuli share common sensory channels or stimulate overlapping subsets of receptors.…”

Section: Factors That Influence Psychophysical Measures Of Irritationmentioning

confidence: 98%

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Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans

Doty

Cometto‐Muñiz

Jalowayski

et al. 2004

Critical Reviews in Toxicology

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133

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Section: Factors That Influence Psychophysical Measures Of Irritationmentioning

confidence: 98%

“…138 The LMS has been successfully employed in a number of nasal and oral irritation studies. 5,76,139,140 The reader is referred elsewhere for discussions of the properties of rating scales, including the influence of category number on their psychometric properties.…”

Section: Insert Figure 6 About Herementioning

confidence: 99%

Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans

Doty

Cometto‐Muñiz

Jalowayski

et al. 2004

Critical Reviews in Toxicology

Self Cite

133

View full text Add to dashboard Cite

“…Indeed, in another study Dalton et al. (29) reported that in a positive bias condition, subjects exposed to 1,967 mg/m3 acetone reported significantly less irritation and fewer health symptoms than those in the neutral or negative bias condition.…”

Section: Discussionmentioning

confidence: 91%

1998 equivalence of sensory responses to single and mixed volatile organic compounds at equimolar concentrations.

Prah

1998

Environ Health Perspect

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Exposure to low levels of chemicals indoors is often to a mixture of volatile organic compounds (VOCs). It is of interest to determine if the symptomatic and sensory responses can be attributed to a single chemical or to a mixture of chemicals. To determine if sensory or symptomatic responses differ with exposure to single or mixed VOCs, 100 female subjects participated in a 6-hr exposure study. Subjects were exposed to one of six equimolar concentrations equivalent to 24 mg/m3 toluene, control, m-xylene, n-butyl acetate, m-xylene plus n-butyl acetate, a mixture of 21 chemicals including n-butyl acetate and m-xylene, and to the same mixture of chemicals without n-butyl acetate and m-xylene (19 chemicals). The results indicated that there was no difference in reporting of symptoms or sensory responses between the exposures. When the control group was added, some variables, primarily odor intensity and nasal irritation, attained significance. Images Figure 1 Figure 2 Figure 3

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“…We have found that the criterion for calling a sensation "barely" pungent, within an odorous background, varies widely from subject to subject. Under these conditions it has been shown that reports of nasal irritation are strongly influenced by response bias (18,19). To solve the problem we have measured nasal pungency thresholds in participants lacking olfaction, i.e., anosmics, for whom odors do not interfere.…”

Section: Introductionmentioning

confidence: 99%

Trigeminal and Olfactory Chemosensory Impact of Selected Terpenes

Cometto‐Muñiz

Cain

Abraham

et al. 1998

Pharmacology Biochemistry and Behavior

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COMETTO-MUÑIZ, J. E., W. S. CAIN, M. H. ABRAHAM AND R. KUMARSINGH. Trigeminal and olfactory chemosensory impact of selected terpenes. PHARMACOL BIOCHEM BEHAV. In Experiment 1, four normosmics and four anosmics (3 congenital, 1 idiopathic) provided odor and nasal pungency thresholds, respectively, for the following terpenes: ∆ 3 -carene, p-cymene, linalool, 1,8-cineole, and geraniol, plus the structurally-related compound cumene. Additionally, all subjects provided nasal localization (i.e., right/left) and eye irritation thresholds. Trigeminally-mediated thresholds (i.e., nasal pungency, nasal localization, and eye irritation) lay about three orders of magnitude above odor thresholds -which ranged between 0.1 and 1.7 ppm. The results implied uniform chemesthetic sensitivity across tasks and sites of impact. In Experiment 2, normosmics and anosmics provided odor and nasal pungency thresholds, respectively, for three pairs of isomeric terpenes: α-and γ-terpinene, α-and ß-pinene, and R(+)-and S(-)-limonene.Odor thresholds ranged between 1.4 and 19 ppm -that is, about an order of magnitude higher than those of the previous terpenes -with no substantial differences between odor thresholds of members of a pair. Regarding chemesthetic impact, only α-terpinene evoked nasal pungency. The overall outcome suggests comparable trigeminal chemosensitivity between nose and eyes and between normosmics and anosmics, as shown before for homologous n-alcohols. It also lends support to a previously-derived solvation model of the chemesthetic potency of airborne substances, and indicates the likely importance of certain molecular-size restrictions for effective trigeminal impact.

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Perceived odor, irritation, and health symptoms following short-term exposure to acetone

Cited by 86 publications

References 33 publications

Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans

Assessment of Upper Respiratory Tract and Ocular Irritative Effects of Volatile Chemicals in Humans

1998 equivalence of sensory responses to single and mixed volatile organic compounds at equimolar concentrations.

Trigeminal and Olfactory Chemosensory Impact of Selected Terpenes

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