Perceived stress and cortisol levels predict speed of wound healing in healthy male adults

Ebrecht, M.; Hextall, Justine; Kirtley, Lauren-Grace; Taylor, Alice; Dyson, Mary; Weinman, John

doi:10.1016/s0306-4530(03)00144-6

Cited by 293 publications

(229 citation statements)

References 39 publications

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“…Broadbent and Koschwanez 2012;House 2015). Most of these studies focused on the effects of psychosocial distress on wound healing and consistently reported impaired wound healing across different wound models and different stressors (Bosch et al 2007;ColeKing and Harding 2001;Ebrecht et al 2004;Garg et al 2001;Kiecolt-Glaser et al 2005;Maple et al 2015). A meta-analysis revealed a robust association between stress and impaired healing (Walburn et al 2009).…”

Section: Introductionmentioning

confidence: 99%

The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study

et al. 2017

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Psychological factors have been shown to influence the process of wound healing. This study examined the effect of Mindfulness-Based Stress Reduction (MBSR) on the speed of wound healing. The local production of pro-inflammatory cytokines and growth factors was studied as potential underlying mechanism. Forty-nine adults were randomly allocated to a waiting-list control group (n = 26) or an 8-week MBSR group (n = 23). Preand post-intervention/waiting period assessment for both groups consisted of questionnaires. Standardized skin wounds were induced on the forearm using a suction blister method. Primary outcomes were skin permeability and reduction in wound size monitored once a day at day 3, 4, 5, 6, 7, and 10 after injury. Secondary outcomes were cytokines and growth factors and were measured in wound exudates obtained at 3, 6, and 22 h after wounding. Although there was no overall condition effect on skin permeability or wound size, post hoc analyses indicated that larger increases in mindfulness were related to greater reductions in skin permeability 3 and 4 days after wound induction. In addition, MBSR was associated with lower levels of interleukin (IL)-8 and placental growth factor in the wound fluid 22 h after wound induction. These outcomes suggest that increasing mindfulness by MBSR might

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Section: Introductionmentioning

confidence: 99%

The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study

et al. 2017

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“…In other words, during the healing period, participants who performed expressive writing prior to wounding experienced improvements in positive and negative affect, whereas those who performed expressive writing after wounding experienced deteriorations in positive affect and increases in negative affect, which may have influenced healing. Previous research has linked optimism to better healing (which could be likened to positive affective states), and linked depression with worse healing (which could be likened to negative affective states; Cole-King & Harding, 2001;Ebrecht et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

The effects of expressive writing before or after punch biopsy on wound healing

Robinson

Jarrett

Vedhara

et al. 2017

Brain, Behavior, and Immunity

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“…Cortisol reduces the immunoinflammatory response, suppresses cellular differentiation and proliferation, inhibits the regeneration of endothelial cells and delays collagen synthesis. In the presence of cortisol, T-cells become less responsive to the interleukin-1(IL-1) signalling for the production of growth factors that facilitate T-cell proliferation 38 . Therefore, pain is one of the most important challenges that must be faced in wound care treatment 39 .…”

Section: Anesthetic Propertiesmentioning

confidence: 99%

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Lindon¹,

Cruz²,

Cabral³

et al. 2016

IJPSR

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ABSTRACT:Lactobacillus plantarum culture supernatants (LAPS) have antimicrobial, pro-healing and anesthetic properties, so our medical team applied whole cultures and LAPS in chronic wounds with encouraging results. Metabolites responsible for LAPS properties and its action mechanism were previously determined. Objective: to design methods and culture media to increase the production of LAPS metabolites and optimize it´s therapeutic effectiveness. Modifications in MRS broth composition were made and L. plantarum was cultivated in the resulting different media with different physicochemical conditions to obtain modified supernatants (LAPS m ). Antimicrobial and anti-biofilm activity (crystal violet) of LAPS m on strains typically isolated from chronic wounds (Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis and Serratiamarcescens), was tested. Concentration of barbiturates in LAPS m was quantified by GCMS and its relative anesthetic potency in healthy volunteers was evaluated. DNAase and auto inducers type 2biological activity in LAPS m were quantified. In addition, a safety assessment of LAPS m application on healthy skin of 200 volunteers was performed. LAPS m obtained from media with high concentrations of yeast extract possessed the greatest anesthetic power. Those containing greater amount of proteins, cations and surfactants had the highest capacity of biofilm disruption (p<0.01). When glucose and galactose concentration were increased in media, LAPS m had the greatest antimicrobial power (p<0.05). Finally, there is great safety in the application of LAPS m as no edema or erythema was observed. The results obtained will allow the manufacture of LAPS m with greater therapeutic effectiveness and even custom properties for each type of wound.

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Perceived stress and cortisol levels predict speed of wound healing in healthy male adults

Cited by 293 publications

References 39 publications

The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study

The effect of Mindfulness-Based Stress Reduction on wound healing: a preliminary study

The effects of expressive writing before or after punch biopsy on wound healing

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