Perceived Worsening of Tics in Adult Patients with Tourette Syndrome after the <scp>COVID</scp>‐19 Outbreak

Mataix‐Cols, David; Ringberg, Helene; Cruz, Lorena Fernández de la

doi:10.1002/mdc3.13004

Cited by 26 publications

(26 citation statements)

References 3 publications

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“…The COVID-19 pandemic has had collateral effects on MH [1][2][3][4][5][6][7][8][9] ; to our knowledge, this epidemiologic cross-sectional study was the first analysis to examine differences in MH-related ED visits in the Delta period and to investigate the association of COVID-19 case surges with MH-related ED visits. Study findings suggest that all MH-related ED visit counts were mostly stable into the Delta period (except among Asian persons who had visit increases and people of Native Hawaiian or Other Pacific Islander race and ethnicity who had visit decreases) compared with a pre-Delta period but had declined since the corresponding prepandemic period.…”

Section: Discussionmentioning

confidence: 99%

“…Given that self-reported MH concerns have increased during the pandemic, [1][2][3][4][5][6][7][8][9] poor MH may be untreated or undertreated.…”

Section: Discussionmentioning

confidence: 99%

“…T he COVID-19 pandemic has resulted in greater selfreported symptoms of anxiety, depression, trauma and stress, tics, and other mental disorders among adults into early 2021. [1][2][3][4][5][6][7][8][9] The pandemic may also have had an effect on mental health (MH)-seeking behavior. In addition to a rise in untreated mental disorders, 7 there has been an increase in emergency department (ED) visits for selected aspects of MH in March to October 2020 compared with the prepandemic period.…”

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confidence: 99%

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Changes and Inequities in Adult Mental Health–Related Emergency Department Visits During the COVID-19 Pandemic in the US

et al. 2022

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Section: Discussionmentioning

confidence: 99%

“…Given that self-reported MH concerns have increased during the pandemic, [1][2][3][4][5][6][7][8][9] poor MH may be untreated or undertreated.…”

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Changes and Inequities in Adult Mental Health–Related Emergency Department Visits During the COVID-19 Pandemic in the US

et al. 2022

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“…A COVID survey of 178 adults with a tic disorder in Europe and North America found that approximately half (48%) of respondents reported a perceived worsening in their tic symptoms, 8% reported tic improvement, with the remainder (44%) reporting no change in tic symptoms. Adults reporting a worsening of symptoms were younger and with more severe existing tics, although no impact of comorbidity was found [ 27 ]. To the best of the authors’ knowledge, to date, the only study in young people with tics was a survey conducted in Italy with parent respondents.…”

Section: Introductionmentioning

confidence: 99%

The COVID-19 pandemic and its impact on tic symptoms in children and young people: a prospective cohort study

Hall

Marston

Khan

et al. 2022

Child Psychiatry Hum Dev

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To understand how children and young people with tic disorders were affected by COVID-19, we compared pre and during pandemic scores on the Yale Global Tic Severity Scale (YGTSS). Participants were young people (N = 112; male:78%; 9–17 years) randomised to the control arm of the “ORBIT-Trial” (ISRCTN70758207, ClinicalTrials.gov-NCT03483493). For this analysis, the control arm was split into two groups: one group was followed up to 12-months’ post-randomisation before the pandemic started (pre-COVID group, n = 44); the other group was impacted by the pandemic at the 12-month follow-up (during-COVID group, n = 47). Mixed effects linear regression modelling was conducted to explore differences in YGTSS at 6- and 12-months post-randomisation. There were no significant differences in tic symptom or severity between participants who were assessed before and during COVID-19. This finding was not influenced by age, gender, symptoms of anxiety or autism spectrum disorder. Thus, the COVID-19 pandemic did not significantly impact existing tic symptoms.

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“…This has been shown to increase the severity of tics of patients with CTD and TS. 11 In a clinical trial, this would imply a potential increase in the YGTSS-TTS due to the COVID-19 pandemic in patients recruited before the start of the COVID-19 pandemic and assessed at 13 weeks during the pandemic. On the other hand, the same measures transform the extent to which tics interfere with normal functioning.…”

Section: Introductionmentioning

confidence: 99%

Potential impact of COVID‐19 on ongoing clinical trials: a simulation study with the neurological Yale Global Tic Severity Scale based on the CANNA‐TICS study

Lasch

Guizzaro

Dávila

et al. 2021

Pharmaceutical Statistics

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The COVID‐19 pandemic has manifold impacts on clinical trials. In response, drug regulatory agencies and public health bodies have issued guidance on how to assess potential impacts on ongoing clinical trials and stress the importance of a risk‐assessment as a pre‐requisite for modifications to the clinical trial conduct. This article presents a simulation study to assess the impact on the power of an ongoing clinical trial without the need to unblind trial data and compromise trial integrity. In the context of the CANNA‐TICS trial, investigating the effect of nabiximols on reducing the total tic score of the Yale Global Tic Severity Scale (YGTSS‐TTS) in patients with chronic tic disorders and Tourette syndrome, the impact of the two COVID‐19 related intercurrent events handled by a treatment policy strategy is investigated using a multiplicative and additive data generating model. The empirical power is examined for the analysis of the YGTSS‐TTS as a continuous and dichotomized endpoint using analysis techniques adjusted and unadjusted for the occurrence of the intercurrent event. In the investigated scenarios, the simulation studies showed that substantial power losses are possible, potentially making sample size increases necessary to retain sufficient power. However, we were also able to identify scenarios with only limited loss of power. By adjusting for the occurrence of the intercurrent event, the power loss could be diminished to different degrees in most scenarios. In summary, the presented risk assessment approach may support decisions on trial modifications like sample size increases, while maintaining trial integrity.

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Perceived Worsening of Tics in Adult Patients with Tourette Syndrome after the COVID‐19 Outbreak

Cited by 26 publications

References 3 publications

Changes and Inequities in Adult Mental Health–Related Emergency Department Visits During the COVID-19 Pandemic in the US

Changes and Inequities in Adult Mental Health–Related Emergency Department Visits During the COVID-19 Pandemic in the US

The COVID-19 pandemic and its impact on tic symptoms in children and young people: a prospective cohort study

Potential impact of COVID‐19 on ongoing clinical trials: a simulation study with the neurological Yale Global Tic Severity Scale based on the CANNA‐TICS study

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