Percentage fat fraction in magnetic resonance imaging: upgrading the osteoporosis-detecting parameter

Chang, Rong; Ma, Xiancang; Jiang, Yu; Huang, Dageng; Chen, Xiujin; Zhang, Ming; Hao, Dingjun

doi:10.1186/s12880-020-00423-0

Cited by 16 publications

(8 citation statements)

References 29 publications

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“…This study was conducted to investigate the role of CT and MR in predicting BMD and TBS. Previously, several studies tried to diagnose osteoporosis through CT or MR 12 – 14 , 17 , 18 , but to the best of our knowledge, this study is the first to reveal a relationship with TBS. In this study, the HU value from CT and the PDFF from MR showed a correlation with BMD and TBS.…”

Section: Discussionmentioning

confidence: 83%

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CT and MR for bone mineral density and trabecular bone score assessment in osteoporosis evaluation

Lee,

Park,

Kwack

et al. 2023

Sci Rep

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Dual energy X-ray absorptiometry (DXA) is widely used modality for measuring bone mineral density (BMD). DXA is used to measure the quantitative areal BMD of bone, but has the disadvantage of not reflecting the bone architecture. To compensate for this disadvantage, trabecular bone score (TBS), a qualitative parameter of trabecular microarchitecture, is used. Meanwhile, there have been recent attempts to diagnose osteoporosis using the Hounsfield unit (HU) from CT and MR-based proton density fat fraction (PDFF) measurements. In our study, we aimed to find out the correlation between HU/PDFF and BMD/TBS, and whether osteoporosis can be diagnosed through HU/PDFF. Our study revealed that the HU value showed a moderate to good positive correlation with BMD and TBS. PDFF showed a fair negative correlation with BMD and TBS. In diagnosing osteopenia and osteoporosis, the HU value showed good performance, whereas the PDFF showed fair performance. In conclusion, both HU values and PDFF can play a role in predicting BMD and TBS. Both HU values and PDFF can be used to predict osteoporosis; further, CT is expected to show better results.

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Section: Discussionmentioning

confidence: 83%

“…Recently, there have been attempts to diagnose osteoporosis using MR-based proton density fat fraction (PDFF) measurements 17 , 18 . In the bone marrow, osteoblasts and adipocytes differentiate from common progenitor cells 19 .…”

Section: Introductionmentioning

confidence: 99%

CT and MR for bone mineral density and trabecular bone score assessment in osteoporosis evaluation

Lee,

Park,

Kwack

et al. 2023

Sci Rep

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“…Chang et al studied the correlation between FF values measured by MRI and BMD values measured by DXA and found that FF values were highly negatively correlated with aBMD values (r = −0.93, P < 0.001), which is signi cantly higher than our results (r = −0.515, P < 0.001). This is probably because they included patients over 50 years of age, and the sample size was relatively small [30]. The results of ROC analysis showed that FF values were more effective in assessing low bone mass measured by QCT than by DXA, so QCT scans combined with IDEAL-IQ sequences would be superior to complete a comprehensive assessment of osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Quantitative analysis of vertebral fat fraction in osteoporosis using IDEAL-IQ sequences

Zhu

Sheng

2023

Preprint

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Objective To investigate the predictive value of vertebral fat fraction (FF) values from IDEAL-IQ sequences in distinguishing between normal bone mass, osteopenia, and osteoporosis.Methods We recruited 105 women and 69 men over 30 years of age who voluntarily underwent DXA, QCT scans, and MRI examinations and collected clinical information from each subject. Bone mineral density (BMD) values measured by DXA and QCT were used as reference standards. The intra-observer correlation coefficient (ICC) was used to assess the reproducibility of inter-observer and intra-observer measurements. One-way ANOVA, Pearson correlation analysis, and subject work characteristic curve analysis were performed.Results The age, height, weight, BMD, and FF values in the DXA and QCT subgroups were significantly different (P < 0.05). Interestingly, FF was correlated with visceral adiposity (r = 0.221, P = 0.003) in the QCT grouping. FF was moderately negatively correlated with aBMD values (r = − 0.515, P < 0.001; after correcting for gender and age: r = − 0.316, P < 0.001), and FF showed a significant negative correlation with vBMD (r = − 0.790, P < 0.001; after correcting for gender and age: r = − 0.601, P < 0.001). Lumbar FF was positively correlated with age (r = 0.643, P < 0.001). In the DXA subgroup, the area under the curve (AUC) value of the FF values for distinguishing low bone mass was estimated to be 0.714, with a sensitivity of 0.822, a specificity of 0.518, and a cut-off value of 42.85%. In the QCT subgroup, the AUC of the FF values for distinguishing low bone mass was estimated to be 0.869, with a sensitivity of 0.841, a specificity of 0.721, and a cut-off value of 47.97%.Conclusions The vertebral FF value from IDEAL-IQ sequences has the potential to be a new biological marker for the assessment of osteopenia and osteoporosis. The FF value was more effective in assessing low bone mass measured by QCT than DXA, so QCT combined with IDEAL-IQ sequences is superior for obtaining a comprehensive assessment of osteoporosis.

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“…척추체와 대퇴경부의 지방신호분율(FF)은 골밀도(BMD)와 음의 상관관계를 보인다는 사실이 보고되고 있으나( 19 20 21 22 ), 슬관절 자기공명영상을 이용한 FF와 BMD의 상관관계에 관한 연구는 아직까지 부족한 실정이다. 또한, 골다공증은 골절뿐만 아니라 슬관절의 골관절염이나 SIFK 발생에도 위험인자가 될 수 있다는 점에 주목하였으며( 7 8 9 ), Zheng 등( 23 )은 척수손상 환자군에서 골밀도 감소가 고관절보다 슬관절 주변에서 먼저 나타남을 보고하였다.…”

Section: 고찰unclassified

Correlation Analysis between Fat Fraction and Bone Mineral Density Using the DIXON Method for Fat Dominant Tissue in Knee Joint MRI: A Preliminary Study

Kwack

Park

et al. 2023

J Korean Soc Radiol

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목적 MRI Dixon method (이하 DIXON) 기법을 이용하여 슬관절 지방우세 골조직의 지방신호분율(fat signal fraction; 이하 FF)을 구하고 골밀도(bone mineral density; 이하 BMD)와 상관관계 분석을 시행하였다. 대상과 방법 본원 슬관절 DIXON 영상을 촬영한 환자들 중 일 년 이내의 dual energy X-ray absorptiometry가 있는 환자 93명을 후향적으로 분석하였다. DIXON 영상에서 원위부 대퇴골 골간단(femur metaphyseal; 이하 Fm)과 근위부 경골 골간단(tibia metaphyseal; 이하 Tm)의 FF를 계산하였다. FF와 BMD 간 상관관계를 분석하였다. 또, 요추(lumbar spine; 이하 L), 대퇴경부(femoral neck; 이하 FN), 총대퇴골(femur total; 이하 FT)의 BMD 별로 나누고 FF에 대하여 Kruskal-Wallis H test를 시행하였다. 결과 전체 환자군에서 TmFF와 FN-BMD 사이에 유의미한 음의 상관관계를 보였다( r = -0.26, p < 0.05). 여성 환자에서는 TmFF가 FN-BMD, FT-BMD 및 L-BMD와 음의 상관관계를 보였다( r = -0.38, -0.28과 -0.27, p < 0.05). 남성 환자에서는 FmFF가 FN-BMD 및 FT-BMD와 음의 상관관계를 보였다( r = -0.58과 r = -0.42, p < 0.05). 여성 환자들을 세 군으로 나누었을 때 TmFF에 유의한 차이를 보였다( p < 0.05). 남성 환자들을 두 군으로 나누었을 때, FmFF이 군 간에 유의미한 차이를 보였다( p < 0.05). 결론 슬관절 주변의 FF와 BMD는 음의 상관관계를 보였으며, DIXON을 이용한 FF 측정이 BMD 스크리닝에 사용될 수 있는 가능성을 보였다.

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Percentage fat fraction in magnetic resonance imaging: upgrading the osteoporosis-detecting parameter

Cited by 16 publications

References 29 publications

CT and MR for bone mineral density and trabecular bone score assessment in osteoporosis evaluation

CT and MR for bone mineral density and trabecular bone score assessment in osteoporosis evaluation

Quantitative analysis of vertebral fat fraction in osteoporosis using IDEAL-IQ sequences

Correlation Analysis between Fat Fraction and Bone Mineral Density Using the DIXON Method for Fat Dominant Tissue in Knee Joint MRI: A Preliminary Study

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