Percentage of free fat mass is associated with elevated blood pressure in healthy Chinese children

Xu, Renying; Zhang, Xiaomin; Zhou, Yucheng; Wu, Yanping; Gao, Xiang

doi:10.1038/s41440-018-0129-y

Cited by 8 publications

(9 citation statements)

References 32 publications

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“…Some scholars have found that visceral fat and LBM were positively associated with BP in both boys and girls [ 27 , 32 , 33 ]. And another study found that a high percentage of lean body mass was related to a low BP and low hypertension risk among healthy Chinese children [ 34 ]. On the one hand, these inconsistencies may be related to different populations, ethnicities, and regions as well as instruments for measuring body composition.…”

Section: Discussionmentioning

confidence: 99%

Association between body composition and blood pressure in normal-weight Chinese children and adolescents

et al. 2022

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Background The aim of this study was to assess the associations of body fat distribution and lean body mass (LBM) with blood pressure (BP) in normal-weight Chinese children and adolescents. Methods A total of 898 normal-weight Chinese children and adolescents, aged 10–18 years, were included this cross-sectional study via a cluster sampling method. The bioelectrical impedance analysis (BIA) was used to measure body composition. The participants were measured for blood pressure (BP) using a calibrated electronic sphygmomanometer according to the standard method by the "American Hypertension Education Project Working Group". Results Body composition was related to abnormal BP in normal-weight children and adolescents. After the model adjusted for age, smoking, and drinking, regression analysis showed that fat mass percentage (FMP) was negatively associated with abnormal BP, while LBM was positively associated with abnormal BP in boys(P < 0.05). Whereas FMP and visceral fat level (VFL) were positively associated with abnormal BP in girls (P < 0.05). Conclusions There are sex differences in the relationships between total body fat, visceral fat and lean body mass with abnormal BP in normal-weight youths. Therefore, it is of great significance to pay attention to the relative influence of the body composition of the boys and girls in the prevention and treatment of hypertension in youths.

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Section: Discussionmentioning

confidence: 99%

Association between body composition and blood pressure in normal-weight Chinese children and adolescents

et al. 2022

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“… 42 According to a pediatric study on healthy Chinese children, a high fat‐free mass percentage was associated with a low BP and low HTN risk in the fully adjusted model. 43 …”

Section: Discussionmentioning

confidence: 99%

Ectopic pancreatic fat as a risk factor for hypertension in children and adolescents with nonalcoholic fatty liver disease

Lee

Kim

Yang

2021

J of Clinical Hypertension

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Although nonalcoholic fatty liver disease (NAFLD) is known to be a risk factor for cardiovascular diseases, few studies have reported an association between ectopic fat deposition and metabolic complications, including hypertension, in children with NAFLD. The present study evaluated the risk factors for hypertension in children with NAFLD from the aspect of ectopic fat. This cross‐sectional retrospective study investigated 65 children with NAFLD (49 boys, mean age 13.0 ± 3.2 years, mean body mass index z‐score [BMI‐z] 2.5 ± 1.2), who underwent liver biopsy and magnetic resonance imaging‐based fat fraction measurement for ectopic hepatic and pancreatic fats, as well as anthropometry, blood pressure, laboratory tests, and body composition analysis. A logistic regression model was used to identify the risk factors for hypertension. Through a simple logistic regression analysis, age (OR 1.392), BMI‐z (OR 3.971), waist circumference‐to‐height ratio (OR 1.136), fat‐free mass index (OR 1.444), γ‐glutamyl transferase (OR 1.021), quantitative insulin sensitivity check index (OR 0.743), dyslipidemia (OR 5.357), and pancreatic fat fraction (PFF) (OR 1.205) were associated with hypertension. The optimal cut‐off of PFF to divide children with NAFLD into two groups with and without hypertension was 4.39% (area under the curve 0.754, p = .001, sensitivity 82.4%, specificity 73.9%). Multiple logistic regression analysis in the fully adjusted model revealed both BMI‐z (OR 4.912, 95% CI, 1.463–16.497) and PFF (OR 1.279, 95% CI, 1.007–1.624) were independent risk factors for hypertension. In conclusions, in addition to BMI‐z, ectopic pancreatic fat is an important risk factor for hypertension in children with NAFLD.

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“…Moliner‐Urdiales did not find superiority for any of the explored adiposity or anthropometric measurements to predict incident hypertension. Moreover, in a cohort of Chinese children, free fat mass percentage was associated with a higher risk of hypertension. And again in Chinese children, it was shown that BMI was a better predictor than adiposity indices .…”

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confidence: 94%

“…Park et al 3 used a tetrapolar bioelectrical impedance analysis. Although most investigators report bioelectrical impedance analyses to estimate BF%, 5,17,19,20,23 other authors determined BF% by means of other methods such as a chemical four-compartment model 16 or the skinfold thickness measurement. 11 The study by Park et al 3 validates previously reported information on the importance of measuring BF% even in non-obese individuals to detect those who have an increased risk of developing hypertension, in a Korean population.…”

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confidence: 99%

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Prognostic value of adiposity indices for hypertension

Oliveras

2019

J of Clinical Hypertension

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Percentage of free fat mass is associated with elevated blood pressure in healthy Chinese children

Cited by 8 publications

References 32 publications

Association between body composition and blood pressure in normal-weight Chinese children and adolescents

Association between body composition and blood pressure in normal-weight Chinese children and adolescents

Ectopic pancreatic fat as a risk factor for hypertension in children and adolescents with nonalcoholic fatty liver disease

Prognostic value of adiposity indices for hypertension

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