Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2

Rhodes, Jack; Yang, Huanjie; Moussu, Steven; Boutrot, Freddy; Santiago, Julia; Zipfel, Cyril

doi:10.1038/s41467-021-20932-y

Cited by 111 publications

(99 citation statements)

References 53 publications

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“…10a ). Our study is consistent with an accompanying report in which MIK2 was identified as a receptor of plant SCOOPs and mediated response to Fusarium SCOOP-like peptides 47 .…”

Section: Discussionsupporting

confidence: 93%

“…In Fusarium spp., the SCOOPL motif we identified is located in the N-terminus of a highly conserved GAL4 DNA-binding domain-containing protein with uncharacterized functions. It is possible that SCOOPL motifs are also present in some other proteins in Fusarium spp 47 . Some of these SCOOPLs are active in triggering MIK2- and BAK1/SERK4-dependent immune responses (Fig.…”

Section: Discussionmentioning

confidence: 99%

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The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes

et al. 2021

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Sessile plants encode a large number of small peptides and cell surface-resident receptor kinases, most of which have unknown functions. Here, we report that the Arabidopsis receptor kinase MALE DISCOVERER 1-INTERACTING RECEPTOR-LIKE KINASE 2 (MIK2) recognizes the conserved signature motif of SERINE-RICH ENDOGENOUS PEPTIDEs (SCOOPs) from Brassicaceae plants as well as proteins present in fungal Fusarium spp. and bacterial Comamonadaceae, and elicits various immune responses. SCOOP signature peptides trigger immune responses and altered root development in a MIK2-dependent manner with a sub-nanomolar sensitivity. SCOOP12 directly binds to the extracellular leucine-rich repeat domain of MIK2 in vivo and in vitro, indicating that MIK2 is the receptor of SCOOP peptides. Perception of SCOOP peptides induces the association of MIK2 and the coreceptors SOMATIC EMBRYOGENESIS RECEPTOR KINASE 3 (SERK3) and SERK4 and relays the signaling through the cytosolic receptor-like kinases BOTRYTIS-INDUCED KINASE 1 (BIK1) and AVRPPHB SUSCEPTIBLE1 (PBS1)-LIKE 1 (PBL1). Our study identifies a plant receptor that bears a dual role in sensing the conserved peptide motif from phytocytokines and microbial proteins via a convergent signaling relay to ensure a robust immune response.

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“…10a ). Our study is consistent with an accompanying report in which MIK2 was identified as a receptor of plant SCOOPs and mediated response to Fusarium SCOOP-like peptides 47 .…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes

et al. 2021

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“…The salthypersensitive phenotype of mik2 mutant can be suppressed by the1-1, a null mutation of THE1 [134]. Recently, the serine rich endogenous peptide (SCOOP) phytocytokines were identified as the ligands of MIK2 to trigger immune responses [135], but whether the SCOOP peptides participate in MIK2-mediated regulation of salt tolerance is still unknown. FEI1 and FEI2 are two LRR-RLKs that are associated with cellulose synthesis and anisotropic cell expansion and are involved in CWI sensing [136].…”

Section: Cell Wall Integrity Sensing and Signal Transduction Under High Salinitymentioning

confidence: 99%

Maintenance of Cell Wall Integrity under High Salinity

Liu

Zhang

Long

et al. 2021

IJMS

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Cell wall biosynthesis is a complex biological process in plants. In the rapidly growing cells or in the plants that encounter a variety of environmental stresses, the compositions and the structure of cell wall can be dynamically changed. To constantly monitor cell wall status, plants have evolved cell wall integrity (CWI) maintenance system, which allows rapid cell growth and improved adaptation of plants to adverse environmental conditions without the perturbation of cell wall organization. Salt stress is one of the abiotic stresses that can severely disrupt CWI, and studies have shown that the ability of plants to sense and maintain CWI is important for salt tolerance. In this review, we highlight the roles of CWI in salt tolerance and the mechanisms underlying the maintenance of CWI under salt stress. The unsolved questions regarding the association between the CWI and salt tolerance are discussed.

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“…Recientemente, el péptido SSP8 ha sido descrito como PROSCOOP5 y se ha demostrado que su expresión se induce con el tratamiento de O3 y la infección con PsPto y B. cinerea (Gully et al, 2019). Cabe destacar que otro miembro de la familia, SCOOP12, ha demostrado tener un papel relevante en la inmunidad y actuar como una fitocitoquina en Arabidopsis a través del receptor MIK2 (Gully et al, 2019;Rhodes et al, 2021).…”

Section: Discussionunclassified

“…La sobreexpresión de prePIP1 y prePIP2 o aplicación exógena de PIP1 y PIP2 resultaron en una mayor resistencia de Arabidopsis a patógenos. Tanto AtPep1 como PIP1 son capaces de amplificar la respuesta inmunitaria desencadenada por flg22 y aumentar la resistencia frente a la bacteria PsPto y al hongo Fusarium oxysporum (Hou et al, 2014 (Gully et al, 2019;Rhodes et al, 2021).…”

Section: Aminoácidos Extracelulares Y Glutatiónunclassified

La proteína quinasa YODA regula respuestas de inmunidad y la resistencia a patógenos de Arabidopsis thaliana y tomate (Solanum lycopersicum)

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vii iii. ABREVIATURAS ABC ATP-binding cassette (casete de unión a ATP) ADNc ADN complementario ADNg ADN genómico [Ca 2+ ]cit Concentración de calcio citoplásmico 35S Promotor 35S del virus del mosaico de la coliflor 3xHA 3 epítopos de hemaglutinina 4MI3G 4-metoxi-I3G ABA Ácido abscísico ACC Ácido 1-aminociclopropano-1-carboxílico ACS ACC sintasa ADN Ácido desoxirribonucléico ADN-T ADN de transferencia AGB1 Guanine nucleotide-binding protein subunit-β 1 AGG1/2 Guanine nucleotide-binding protein subunit-γ 1/2 AHK2-4 Arabidopsis histidin kinase 2-4 ANX1, ANX2 ANXUR 1, ANXUR 2 AP2 Apetala 2 AP2/ERF APETALA2/Ethylene response factor ARN Ácido ribonucléico ARN Ácido ribonucleico ARNm ARN mensajero ARR Arabidopsis response regulator ATAF Arabidopsis thaliana activating factor ATP Adenosina trifosfato AtPep1 A. thaliana plant elicitor peptide 1 (péptido elicitor de planta 1 de A. thaliana) AUX Auxina BAK1 BRI1-associated receptor kinase 1 bHLH Basic helix-loop-helix (hélice-bucle-hélice básica) BIK1 Botrytis-induced kinase 1 BIR1 BAK1-interacting receptor-like kinase 1 BR Brasinosteroide BRI1 Brassinosteroid insensitive 1 BTH Benzotiadiazol bZIP Basic leucine zipper (cremallera de leucina básica) Ca 2+ Ión calcio CaMV Cauliflower mosaic virus (virus del mosaico de la coliflor) CAP Cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 protein CAPE 1 CAP-derived peptide 1 CA-YDA Forma constitutivamente activa de YDA CBEL Cellulose-binding elicitor lectin CC Coiled-coil (cola superenrollada) CDPK/CPK Calcium-dependant protein kinase (proteína quinasas dependiente de calcio) viii CDS Codifying sequence (secuencia codificante) CEBiP Chitin elicitor binding protein CERK1 Chitin elicitor receptor kinase 1 CES101 Callus expression of RBCS CESA Celulosa sintasa CK Citoquinina COI1 Coronatine insensitive 1 COR Coronatina CRK Cysteine-rich receptor-like protein kinase (proteína quinasa parecida a los de tipo receptor rico en cisteína) CrRLKL1 Catharanthus roseus receptor-like kinase 1-like protein CRRSP Cysteine-rich receptor-like secreted protein (proteína secretada parecida a los de tipo receptor rico en cisteína) C-terminal Carboxilo terminal CTR1 Constitutive triple response 1 CUC Cup-shaped cotyledon CWDE Cell wall-degrading enzymes (enzimas degradantes de pared) DA Deshidroabietinal DAMP Damage-associated molecular pattern (patrón molecular asociado a daño) DE Desviación estándar DEG Differentially expressed genes (genes expresados diferencialmente) DELLA Aspártico-glutámico-leucina-leucina-alanina dH2O Agua destilada DIC Differential Interference Contrast (contraste diferencial interferencial) DO600 Densidad óptica a 600 nm DORN1 Does not respond to nucleotides 1 DP Degree of polymerization (grado de polimerización) dpi Días post inoculación dsARN ARN de doble hebra DTI DAMP-triggered immunity (inmunidad desencadenada por DAMP) DUF Domain of unknow function (dominio de función desconocida) EAMP Egg-associated molecular pattern (patrón molecular asociado a huevos) eATP ATP extracelular EDS1 Enhanced disease ...

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Perception of a divergent family of phytocytokines by the Arabidopsis receptor kinase MIK2

Cited by 111 publications

References 53 publications

The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes

The Arabidopsis MIK2 receptor elicits immunity by sensing a conserved signature from phytocytokines and microbes

Maintenance of Cell Wall Integrity under High Salinity

La proteína quinasa YODA regula respuestas de inmunidad y la resistencia a patógenos de Arabidopsis thaliana y tomate (Solanum lycopersicum)

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