Perception of hand movement by mirror reflection evokes brain activation in the motor cortex contralateral to a non-moving hand

Debnath, Ranjan; Franz, Elizabeth A.

doi:10.1016/j.cortex.2016.04.015

Cited by 29 publications

(27 citation statements)

References 39 publications

(54 reference statements)

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“…Increased activation of these areas as well as MVF-related activity of the insular, precuneus and cingulate cortices are associated with increased attentional demands that are known to be modulated by goal-oriented behavior (Fink et al, 1999; Adamovich et al, 2009a; Michielsen et al, 2011b; Wasaka and Kakigi, 2012; Wang et al, 2013a). The possible effect of attentional demands on MVF is illustrated in the conflicting findings of two recent articles using EEG assess MVF in which finger flexion and extension movements were either equally intentional (Debnath and Franz, 2016) or differed in intention (one being more automatic; Praamstra et al, 2011). When movement phases differed in intention MVF affects were found to be stronger for the intentional movement, however when movements were equally intentional (requiring similar attention demands) no difference was seen between movement phases.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous investigations using transcranial magnetic stimulation (TMS) to probe corticospinal excitability (CSE) have indicated increased amplitude of motor evoked potentials (MEPs) in the muscles of the resting hand homologous to those in the active hand that were involved in the task (Garry et al, 2005; Funase et al, 2007; Nojima et al, 2012; Kumru et al, 2016). Ipsilateral sensorimotor cortex changes associated with MVF have also been measured as a change in signal laterality using EEG and MEG (Touzalin-Chretien and Dufour, 2008; Praamstra et al, 2009, 2011; Tominaga et al, 2009; Touzalin-Chretien et al, 2010; Debnath and Franz, 2016; Franz et al, 2016), and with fMRI, quantified as an increased BOLD response in sensorimotor areas ipsilateral to the moving hand (Michielsen et al, 2011a,b; Hamzei et al, 2012; Saleh et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

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The Effects of Mirror Feedback during Target Directed Movements on Ipsilateral Corticospinal Excitability

Yarossi

Manuweera

Adamovich

et al. 2017

Front. Hum. Neurosci.

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Mirror visual feedback (MVF) training is a promising technique to promote activation in the lesioned hemisphere following stroke, and aid recovery. However, current outcomes of MVF training are mixed, in part, due to variability in the task undertaken during MVF. The present study investigated the hypothesis that movements directed toward visual targets may enhance MVF modulation of motor cortex (M1) excitability ipsilateral to the trained hand compared to movements without visual targets. Ten healthy subjects participated in a 2 × 2 factorial design in which feedback (veridical, mirror) and presence of a visual target (target present, target absent) for a right index-finger flexion task were systematically manipulated in a virtual environment. To measure M1 excitability, transcranial magnetic stimulation (TMS) was applied to the hemisphere ipsilateral to the trained hand to elicit motor evoked potentials (MEPs) in the untrained first dorsal interosseous (FDI) and abductor digiti minimi (ADM) muscles at rest prior to and following each of four 2-min blocks of 30 movements (B1–B4). Targeted movement kinematics without visual feedback was measured before and after training to assess learning and transfer. FDI MEPs were decreased in B1 and B2 when movements were made with veridical feedback and visual targets were absent. FDI MEPs were decreased in B2 and B3 when movements were made with mirror feedback and visual targets were absent. FDI MEPs were increased in B3 when movements were made with mirror feedback and visual targets were present. Significant MEP changes were not present for the uninvolved ADM, suggesting a task-specific effect. Analysis of kinematics revealed learning occurred in visual target-directed conditions, but transfer was not sensitive to mirror feedback. Results are discussed with respect to current theoretical mechanisms underlying MVF-induced changes in ipsilateral excitability.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effects of Mirror Feedback during Target Directed Movements on Ipsilateral Corticospinal Excitability

Yarossi

Manuweera

Adamovich

et al. 2017

Front. Hum. Neurosci.

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“…EEG data were band-pass filtered in the range of 0.1–50.0 Hz and applied to a common average reference montage. We removed artifacts using previously described methods 24,25. Briefly, artifacts generated by blinking, eye movements, facial muscle activity, or body movements were removed using a specially designed spatial filter in EMSE Suite 5.4 and visual inspection of the frontal EEG trace (Fp1, Fp2).…”

Section: Methodsmentioning

confidence: 99%

Dysesthesia symptoms produced by sensorimotor incongruence in healthy volunteers: an electroencephalogram study

Katayama¹,

Osumi²,

Kodama³

et al. 2016

JPR

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ObjectivesPathological pain such as phantom limb pain is caused by sensorimotor incongruence. Several studies with healthy participants have clearly indicated that dysesthesia, which is similar to pathological pain, is caused by incongruence between proprioception and/or motor intention and visual feedback. It is not clear to what extent dysesthesia may be caused by incongruence between motor intention and visual feedback or by incongruence between proprioception and visual feedback. The aim of this study was to clarify the neurophysiology of these factors by analyzing electroencephalograms (EEGs).MethodsIn total, 18 healthy participants were recruited for this study. Participants were asked to perform repetitive flexion/extension exercises with their elbows in a congruent/incongruent position while viewing the activity in a mirror. EEGs were performed to determine cortical activation during sensorimotor congruence and incongruence.ResultsIn the high-frequency alpha band (10–12 Hz), numeric rating scale scores of a feeling of peculiarity were significantly correlated with event-related desynchronization/synchronization under the incongruence and proprioception conditions associated with motor intention and visual feedback (right inferior parietal region; r=−0.63, P<0.01) and between proprioception and visual feedback (right temporoparietal region; r=−0.49 and r=−0.50, P<0.05). In these brain regions, there was a region in which incongruence between proprioception and visual feedback and between motor intention and visual feedback caused an increase in activity.ConclusionThe present findings suggest that neural mechanisms of dysesthesia are caused by incongruence between proprioception associated with motor intention and visual feedback and, in particular, are a result of incongruence between proprioception only and visual feedback.

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“…Our group has shown that MVF can activate and strengthen effective connectivity within sensorimotor areas of the lesioned hemisphere in stroke survivors [3,7]. Several studies have reported a decrease in lateralization of brain activity during movements coupled with MVF, estimated by measuring the Lateralized Readiness Potential [4,5,8], or the Event Related Desynchronization (ERD) of contralateral and ipsilateral motor cortices [9]. Surprisingly, the task used in the majority of MVF investigations (i.e.…”

Section: Introductionmentioning

confidence: 99%

EEG Based Analysis of Cortical Activity during Mirror Visual Feedback Target-Directed Movement

Rohafza

Saleh

Adamovich

2019

2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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In mirror visual feedback (MVF) based rehabilitation, the illusion of mirror reflection of volitional movement of non-paretic limb tends to have a modulatory effect on visuomotor and sensorimotor brain activations. This paper presents EEG based analysis of hemispheric activation asymmetry within the beta band (15-28 Hz) when MVF is combined with a target-directed hand motor task in a block design versus a similar task without any target requirements. MVF coupled with targetdirected movement was associated with a decrease in hemispheric asymmetry in both preparation and execution phases of movement. These results emphasize the potential importance of incorporating visuomotor goals into the task to maximize the rehabilitation outcomes of MVFbased training activities. Numerous neuroimaging techniques, such as TMS, fMRI, MEG, in healthy and stroke population, have shown a modulatory effect of MVF, like increasing activation of the ipsilateral hemisphere or rebalancing abnormal interhemispheric dominance [3-5]. TMS

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Perception of hand movement by mirror reflection evokes brain activation in the motor cortex contralateral to a non-moving hand

Cited by 29 publications

References 39 publications

The Effects of Mirror Feedback during Target Directed Movements on Ipsilateral Corticospinal Excitability

The Effects of Mirror Feedback during Target Directed Movements on Ipsilateral Corticospinal Excitability

Dysesthesia symptoms produced by sensorimotor incongruence in healthy volunteers: an electroencephalogram study

EEG Based Analysis of Cortical Activity during Mirror Visual Feedback Target-Directed Movement

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