Perception of Horizontal Head and Trunk Rotation in Patients with Loss of Vestibular Functions

Abstract

In patients with loss of vestibular functions, we studied psychophysically the self-motion perception for ‘trunk in space’ and ‘head in space’ during various combinations of horizontal head and trunk rotation in the dark. The results were compared to those of normal subjects. For their ‘trunk in space’ perception, the subjects relied on their internal image of space, derived from the vestibular receptors in the head, and referred their trunk to this as a reference by adding to it a nuchal trunk-to-head signal. The patients, by contrast, always considered the trunk as stationary. Obviously because they were devoid of any space cues, they abandoned or suppressed a neck contribution to their ‘trunk in space’ perception, which, in fact, would yield an erroneous perception in almost all conditions in the dark. Both the patients and the subjects based their ‘head in space’ perception on their internal representation of ‘trunk in space’ and added to this a nuchal head-to-trunk signal. However, the patients’ head-to-trunk signal, unlike that of the subjects, was considerably larger than the actual head-to-trunk rotation at low stimulus frequency. We relate this finding to some unconscious modification of their neck muscle activity during passive head rotation. It appears that the patients’ gain of the neck input per se is not increased, but rather that subsets of this input are modified according to the particular function they serve.

Vestibular contribution to path integration deficits in ‘at-genetic-risk’ for Alzheimer’s disease

“…This has striking similarities to Bierbrauer and colleagues who found that a path integration deficit in APOE ε4 carriers emerges only if external visual cues are not available [ 20 ]. These findings are also consistent with limited studies that show path integration impairment in vestibular deficient humans emerges when external cues are not available [ 38 ], supporting the emerging theory that vestibular function plays a mechanistic role in path integration deficits previously observed in adults at-genetic-risk AD.…”

Vestibular contribution to path integration deficits in ‘at-genetic-risk’ for Alzheimer’s disease

“…This has striking similarities to Bierbrauer and colleagues who found that a path integration deficit in APOE ε4 carriers emerges only if external visual cues are not available 4 . These findings are also consistent with limited studies that show path integration impairment in vestibular deficient humans emerges when external cues are not available 19 , supporting the emerging theory that vestibular function plays a mechanistic role in path integration deficits previously observed in adults at-genetic-risk AD.…”