Perchlorate Test in Hyperthyroid Patients Treated with Radioactive Iodine

Kieffer, J; Medeiros‐Neto, Geraldo; Rueda, Rosa Maria Alcobendas; Pieroni, R.R.; Neto, Antonio Coelho; Campusano, Luiz Lopez; Cintra, A.

doi:10.1056/nejm196512092732407

Cited by 10 publications

(1 citation statement)

References 5 publications

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“…This phenomenon has been previously reported after 131 I (Kirkland, 1954;Larsson, 1955;Kieffer et al, 1965) although the frequency of abnormality varied in each series. The three to eight month period, however, revealed a reduction in abnormal test results after 1 3 1 I but an increase after 1 2 5 I.…”

Section: Discussionsupporting

confidence: 81%

Therapeutic iodine 125 for hyperthyroidism: evidence for a special radiobiological effect on the follicular cell

Gray¹,

Greig²,

Gillespie³

1982

BJR

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An IV perchlorate test was used qualitatively to detect a functional abnormality of the colloid-follicular cell interface in patients given 131 I or 125 I for hyperthyroidism. Radiation damage, manifest as abnormal iodide organification, was more prolonged after 125 I and more often accompanied by unremitting hyperthyroidism than after 1 3 1 I. These results conform with theoretical and laboratory data which predict a gradient of deposited radiation across the human follicular cell after therapeutic 1 2 5 I.

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Section: Discussionsupporting

confidence: 81%

Therapeutic iodine 125 for hyperthyroidism: evidence for a special radiobiological effect on the follicular cell

Gray¹,

Greig²,

Gillespie³

1982

BJR

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The perchlorate discharge test with and without supplement of potassium iodide

Friis

1987

J Endocrinol Invest

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The purpose of the study was to compare the discharge of radioactive iodine from the thyroid after po administration of perchlorate with and without supplement of 2 mg potassium iodine (Kl) in 42 euthyroid controls, 26 patients with nontoxic goiter, 39 patients with thyrotoxicosis treated with radioactive iodine, and 39 patients with Pendred's syndrome. The discharge test was found to have a satisfactory specificity with supplement of 2 mg Kl, and was more sensitive to detect an organification defect than the standard perchlorate discharge test without Kl. In all groups of patients a significant discharge occurred after addition of Kl in contrast to healthy persons. Only in the group of patients with Pendred's syndrome a discharge of iodine was found in the perchlorate test without Kl.

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