Percutaneous absorption

Barr, Martin

doi:10.1002/jps.2600510502

Cited by 41 publications

(16 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In search of a vehicle to deliver the medicament into the skin layers (cutaneous delivery), or through the skin and into the systemic circulation (percutaneous absorption), varied kinds of formulation systems and strategies have been evolved. [1][2][3][4][5][6] Among the many, the lipid-based formulations have been in use for decades. [7][8][9][10][11] However, of late, there has been a surge in their number with wide variation and flexibility in the interior designs and structures.…”

Section: Introductionmentioning

confidence: 99%

Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review

2005

View full text Add to dashboard Cite

The purpose of this review is to give an insight into the considerable potential of lecithin organogels (LOs) in the applications meant for topical drug delivery. LOs are clear, thermodynamically stable, viscoelastic, and biocompatible jelly-like phases, chiefly composed of hydrated phospholipids and appropriate organic liquid. These systems are currently of interest to the pharmaceutical scientist because of their structural and functional benefits. Several therapeutic agents have been formulated as LOs for their facilitated transport through topical route (for dermal or transdermal effect), with some very encouraging results. The improved topical drug delivery has mainly been attributed to the biphasic drug solubility, the desired drug partitioning, and the modification of skin barrier function by the organogel components. Being thermodynamically stable, LOs are prepared by spontaneous emulsification and therefore possess prolonged shelf life. The utility of this novel matrix as a topical vehicle has further increased owing to its very low skin irritancy potential. Varied aspects of LOs viz formation, composition, phase behavior, and characterization have been elaborated, including a general discussion on the developmental background. Besides a comprehensive update on the topical applications of lecithin organogels, the review also includes a detailed account on the mechanistics of organogelling.

show abstract

Section: Introductionmentioning

confidence: 99%

Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review

2005

View full text Add to dashboard Cite

show abstract

“…In 1950, Malkinson and Ferguson performed the first successful study concerning percutaneous absorption in human beings, demonstrating that the skin was permeable to topically administered drugs (Barr, 1962). Idson (1975) demonstrated that the epidermic barrier was the limiting factor for the percutaneous absorption and that once the drug passed through the stratum corneum of the epidermis, its absorption was guaranteed.…”

Section: History and Prospectsmentioning

confidence: 99%

“…This being the case, the use of this terminology is not restricted to a single designation (Barr, 1962). Rothman (1954) defined percutaneous absorption as the passage of substances through the skin from one side to another, thus reaching the blood stream.…”

Section: Cutaneous Absorptionmentioning

confidence: 99%

See 1 more Smart Citation

Percutaneous absorption enhancers: mechanisms and potential

Rodrigues

Zanluchi²,

Grebogi

2007

Braz. arch. biol. technol.

View full text Add to dashboard Cite

Transdermal applications of drugs present many advantages in terms of absorption, however this is not easily obtained through the transdermal route. The principle barrier is the stratum corneum and one of the strategies that have been found to promote cutaneous drug penetration is through the use of absorption enhancers. Many substances have been identified as absorption enhancers. Although the list of substances that promote absorption is growing, in most cases, there is a direct correlation between the effects of absorption enhancers and their skintoxicity. The use of these substances depends therefore on studies which focus on local and systemic toxicity, as well as action mechanisms.

show abstract

“…Transdermal drug delivery takes advantage of the relative accessibility of the skin. [3] The drug has to go through these structural layers, encountering several lipophilic and hydrophilic barriers in the dermis, where absorption into the systemic circulation is rapid because of the large capillary bed. Dermis is the thickest of the skin layer (5.3 mm) and include hair follicles, sweat glands, nerve endings and blood and lymph vessels.…”

Section: Introductionmentioning

confidence: 99%

Transdermal study of hydrogel ointments and bandages with antituberculosis activity

Buribayeva

Kunakbayeva

Abebova

et al. 2015

IJBCh

View full text Add to dashboard Cite

Transdermal study for hydrogel ointments and bandages based on polyvinylpirrolidone was conducted for application as transdermal therapeutic drug delivery systems for skin tuberculosis treatment. The ointments and bandages based on polyvinylpyrrolidone (PVP) and carbomer with drugs isoniazid and ethambutol were obtained. The transdermal characteristics were investigated using cellulose membrane and pig skin. The experiment was carried out by the device Franz cell and diffusion coefficient (D), permeability (P) and permeation rates (F) of the drugs were calculated. It was established that the rate of isoniazid penetration through the skin faster than that for ethambutol which is related to the structure peculiarities of drugs. The higher transdermal activity of hydrogel ointments was shown in comparison with hydrogel dressings. Also the prolongation effect of developed transdermal drug delivery systems based on PVP and carbomer was observed.

show abstract

Percutaneous absorption

Cited by 41 publications

References 110 publications

Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review

Lecithin organogels as a potential phospholipid-structured system for topical drug delivery: A review

Percutaneous absorption enhancers: mechanisms and potential

Transdermal study of hydrogel ointments and bandages with antituberculosis activity

Contact Info

Product

Resources

About