Percutaneous coronary intervention causes increase of serum cystatin C concentration even in the patients with a low risk of contrast-induced nephropathy

Tanaga, Kosei; Tarao, Kentarou; Nakamura, Yoshitake; Inoue, Toshihisa; Jo, Kigen; Ishikawa, Takayasu; Miyazaki, Akira

doi:10.1007/s12928-012-0106-3

Cited by 16 publications

(13 citation statements)

References 18 publications

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“…The results of the present study are in agreement with the most results obtained by others reports Kato et al and Mehran et al [19][20][21][22][23][24][25][26][27]. In present study was found a highly significant increment in serum creatinine and cystatin C while decrease in eGFR 24 hours after angiography (p<0.001, 0.01) when compared between two groups (CIN+, CIN-).…”

Section: Discussionsupporting

confidence: 93%

“…In present study was found a highly significant increment in serum creatinine and cystatin C while decrease in eGFR 24 hours after angiography (p<0.001, 0.01) when compared between two groups (CIN+, CIN-). This result is consistent with Wang et al, Liu et al and Nozue et al founded serum level of cystatin C is a reliable marker for CIN at 24 hours p<0.001 and serum creatinine increased significantly at 48 hours, also study carried by Wacker-Gussmann et al [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] found that cystatin C level and the cystatin C/creatinine ratio independently predict the risk of CIN in patients undergoing coronary angiography, but another study by Ribichini et al [32] found a significant increase in serum cystatin C concentrations 12 hours earlier than serum creatinine, therefore a rise of serum cystatin C at 12 hours from baseline was the earliest predictor of CIN than serum creatinine [18].…”

Section: Discussionsupporting

confidence: 91%

“…Low-osmolar contrast media lead to a lower CIN incidence when compared to highosmolar contrast media. Nowadays there is no indication for use of high-osmolar contrast media and therefore this has been almost completely replaced by low-osmolar contrast media that has less effect on development of CIN [25]. Visipaque (iodixanol), is iso-osmolar contrast media (the same osmolarity of blood), non-ionic is a new one with less incidence of nephrotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Although several studies have revealed that serum cystatin C cut off level >1.2 or >1.18 or >1.3 mg/l, 94% sensitivity and 48% specificity is more accurate for diagnostic CIN than serum creatinine [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. While study obtained by Ribichini et al found that absolute changes in serum creatinine proved more accurate than serum cystatin C for predicting CIN at an early stage 12 hours after angiography [18].…”

Section: Discussionmentioning

confidence: 99%

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The Role of Serum Cystatin C in the Early Detection of Contrast-Induced Nephropathy after Coronary Intervention

Fj¹,

Mh²,

Ma³

et al. 2017

J Kidney

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Objective: Contrast induced nephropathy is the most common complication for both coronary angiography and percutaneous coronary intervention. The aim of the present study is to investigate the role of serum cystatin C among patients undergoing coronary angiography for earlier detection of contrast induced nephropathy. Materials and Methods:The study included 80 elective patients attending the cardiology center (48 males, 32 females). The study was conducted in cardiac catheterization unit at Al-Hussein Medical City/ Kerbala Health Directorate-Holy Kerbala, Iraq. Clinical examination and laboratory investigations were made before and 24 hours after angiography. These investigations include: serum creatinine, blood urea, estimated GFR and serum cystatin C.Results: According to the definition, contrast induced nephropathy occurred in 19 patients 23.8% with grade 0 to 2 of renal dysfunction. There were significant increments in serum creatinine, cystatin C and eGFR after 24 hours of angiography/angioplasty procedures p<0.001, 0.01 respectively. Receiver-operating characteristic analysis showed a higher area under the curve for creatinine 0.805 (95% CI=0.688, 0.921) p=0.001, 78.9% sensitivity and 60.7% specificity than serum cystatin C 0.777 (95% CI=0.673-0.881) P=0.001 sensitivity=78.9% and specificity=64%, a cutoff level of cystatin C>7 ng/ml. Conclusion:Cystatin C was a good biomarker for earlier diagnosis of contrast induced nephropathy when compared with blood urea and eGFR.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Role of Serum Cystatin C in the Early Detection of Contrast-Induced Nephropathy after Coronary Intervention

Fj¹,

Mh²,

Ma³

et al. 2017

J Kidney

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“…1 One of the most common complications of percutaneous coronary intervention (PCI) and other type such as diagnostic procedures of the heart is contrast-induced acute kidney injury (CI-AKI). 2 CI-AKI is defined as an increase in serum creatinine of 0.5 mg/dL (44 μmol/L), or a relative 25% increase from the baseline value within 24-48 h following intravascular administration of contrast media.…”

Section: Introductionmentioning

confidence: 99%

Measurement of urinary kidney injury molecule-1 as a predictive biomarker of contrast-induced acute kidney injury

Al-Tu’ma

Dheyauldeen

Al-Saegh

2017

J. contemp. med. sci.

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Objective The aim of the present study is to evaluate the urinary KIM-1 level in the patients after 24 h angiography as a predictive biomarker of contrast-induced acute kidney injury. Methods This study included 80 selective patients attending in the cardiology unit (48 males, 32 females). The study was conducted in the cardiac catheterization unit at Al-Hussein Medical City/ Kerbala. Clinical examination and laboratory investigations were made before and 24 h after angiography, these investigations include: serum creatinine, blood urea and estimated GFR. Urinary KIM-1 was measured before and after 24 h angiography. Results There was no significant difference in urinary KIM-1 when compared between CIN and non CIN group P > 0.05. The level of urinary KIM-1 increased in the patients after 24 h of angiography when compared with baseline level of P < 0.001. Conclusion Urinary KIM-1 was not useful for predicting or detecting CIN. But urinary KIM-1 level may be useful as a biomarker for tubular damage following intravascular administration of contrast media, 24 h.

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Association of Definition of Acute Kidney Injury by Cystatin C Rise With Biomarkers and Clinical Outcomes in Children Undergoing Cardiac Surgery

et al. 2015

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Percutaneous coronary intervention causes increase of serum cystatin C concentration even in the patients with a low risk of contrast-induced nephropathy

Cited by 16 publications

References 18 publications

The Role of Serum Cystatin C in the Early Detection of Contrast-Induced Nephropathy after Coronary Intervention

The Role of Serum Cystatin C in the Early Detection of Contrast-Induced Nephropathy after Coronary Intervention

Measurement of urinary kidney injury molecule-1 as a predictive biomarker of contrast-induced acute kidney injury

Association of Definition of Acute Kidney Injury by Cystatin C Rise With Biomarkers and Clinical Outcomes in Children Undergoing Cardiac Surgery

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