Percutaneous guided biopsy for diagnosing suspected primary malignant bone tumors in pediatric patients: a safe, accurate, and cost-saving procedure

Ceraulo, Antony; Ouziel, Antoine; Lavergne, Emilie; Perrier, Lionel; Decouvelaere, Anne‐Valérie; Chotel, Franck; Thiesse, Philippe; Marec‐Bérard, Perrine

doi:10.1007/s00247-016-3735-3

Cited by 25 publications

(21 citation statements)

References 29 publications

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“…Historically, an incisional (open) biopsy has been the preferred method for tumor tissue sampling in bone sarcomas. However, a percutaneous (needle) biopsy can also provide adequate tumor material to effectively establish the diagnosis of either OS or EWS . Historically, the small amount of tumor material obtained for research purposes has been one of the limitations to performing percutaneous biopsies in patients with bone sarcomas.…”

Section: Introductionmentioning

confidence: 99%

“…However, a percutaneous (needle) biopsy can also provide adequate tumor material to effectively establish the diagnosis of either OS or EWS. [2][3][4][5] Historically, the small amount of tumor material obtained for research purposes has been one of the limitations to performing percutaneous biopsies in patients with bone sarcomas. We have developed a multi-Abbreviations: EWS, Ewing sarcoma; IRB, institutional review board; OS, osteosarcoma; PDX, patient-derived tumor xenograft; TTF, time to tumor formation; US, ultrasound disciplinary team approach to establish an adequate cancer diagnosis and to develop patient-derived tumor xenografts (PDXs) using percutaneous biopsies in patients with bone sarcomas.…”

Section: Introductionmentioning

confidence: 99%

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Generation of patient‐derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas

Rainusso

Cleveland

Hernandez

et al. 2018

Pediatric Blood & Cancer

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One of the limitations of performing percutaneous biopsies in patients with bone sarcomas is the small amount of tumor that can be obtained for research purposes. Here, we describe our experience developing patient‐derived tumor xenografts (PDXs) using percutaneous tumor biopsies in children with bone sarcomas. We generated 14 bone sarcoma PDXs from percutaneous tumor biopsies. We also developed eight bone sarcoma PDXs from surgical resection of primary bone tumors and pulmonary metastases. A multidisciplinary team approach was critical to establish an accurate diagnosis and to provide adequate tumor samples for PDX generation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Generation of patient‐derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas

Rainusso

Cleveland

Hernandez

et al. 2018

Pediatric Blood & Cancer

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“…Numerous publications have reported that CT-guided percutaneous core-needle biopsy is a well-established technique and is effective for the initial diagnosis of musculoskeletal lesions, with a measured diagnostic yield ranging between 70 and 89% and a reported accuracy between 61 and 98% [2–11]. These results confirm the high sensitivity of CT-guided percutaneous needle biopsy for the diagnosis of bone tumors through the use of a minimally invasive procedure, which is associated with cost savings and fewer biopsy complications than open surgical biopsy [6, 7, 10–14]. However, the disadvantage of this guided biopsy method is that metabolically active lesions without distinctive morphology may not be reliably assessable by CT-guided biopsy, and the false-negative biopsy rate of such lesions may be substantially higher with CT-guided biopsy [15].…”

Section: Introductionmentioning

confidence: 71%

PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

Xiao

Liu

et al. 2019

Cancer Imaging

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ObjectiveThe present study aimed to evaluate the diagnostic performance and safety of PET/CT-guided percutaneous core bone biopsy and to compare the PET/CT-guided method to conventional CT-guided percutaneous core biopsies to diagnose Chinese patients with bone tumors and tumor-like lesions.MethodsData for 97 patients with bone tumors and tumor-like lesions diagnosed by percutaneous core bone biopsy from February 2013 to November 2018 were retrospectively analyzed. The study included 42 cases in the PET/CT group and 55 cases in the CT alone group. The diagnostic performance, cost and complications associated with the intervention were compared between the two groups. All patients were eventually confirmed to have bone tumors and tumor-like lesions according to surgical pathology findings.ResultsThere were no significant differences in patient characteristics (P > 0.05). For the patients in the PET/CT group, the overall diagnostic yield of the initial biopsies and the diagnostic accuracy derived from the surgically proven cases were both 97.62%, which was significantly higher than the values in the CT group during the same period (P < 0.05). No major biopsy-related complications (e.g., serious bleeding or tumor dissemination) occurred before, during, or after the intervention. Therefore, no significant difference was observed between the two groups with regard to the complication rate (P > 0.05).ConclusionCompared with CT-guided percutaneous bone biopsy, PET/CT-guided percutaneous bone biopsy is an effective and safe alternative with high diagnostic performance in the evaluation of hypermetabolic bone lesions to diagnose bone tumors and tumor-like lesions.

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“…In our cohort no tumor dissemination along the needle track is found. It is also quite rare in previous studies 9, 13,19 and almost all the reports are related with nephroblastoma 18,21,22 and the prognosis is generally quite good after chemotherapy and excision. Another earlier research on biopsy of renal tumors suggest posterolateral entries to confine tumor soilage instead of peritoneal dissemination.…”

Section: Discussionmentioning

confidence: 91%

“…In previous studies, reported complications included pain, intra-abdominal infection, pneumothorax, hematuria, and hemorrhage 8,9,13,[16][17][18][19][20] . Post-biopsy bleeding including intra-tumoral hematoma is the most common.…”

Section: Discussionmentioning

confidence: 99%

Reliability of Ultrasound-Guided Percutaneous Core Needle Biopsy in Diagnostics of Pediatric Solid Tumors

Chen

Huang

Feng

et al. 2020

Preprint

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Background: Ultrasound-guided percutaneous core needle biopsy (PCNB) has been used more and more frequently in diagnostics of pediatric solid tumors in our center. It is less invasive than an incisional biopsy. However, reports relating to its reliability in clinical practice are limited. Therefore, we aim to investigate the reliability of this technique in the pediatric population. Methods: A 7-year retrospective study including patients [?] 18 years who underwent ultrasound-guided PCNB in our center was conducted. Children who received PCNB and final surgical treatment were included. Their medical records were reviewed. Final surgical pathological diagnoses were used as the gold standard to assess the diagnostic efficiency of PCNB. Results: A total of 169 children were included in our analysis. 87.0% of patients underwent PCNB for abdominal and pelvic masses. 79.1% of biopsies were performed under local anesthesia. There were 141 malignancies and 28 benign lesions confirmed by surgery. The most common malignancy was neuroblastoma (73), and the most common benign condition was fibromatosis. The diagnostic yield was 94.1%. The success rate of PCNB in determining benign and malignant conditions was 94.3% (150/159). Consistency between PCNB and final diagnoses was found in 143 cases, giving a total accuracy of 89.9%. The accuracy for diagnosing malignancies was 96.8% (122/126), and for benign diseases 87.5% (21/24). The difference was not statistically significant (p=0.0818). Severe complications occurred in 6 patients (3.5%). No evidence of needle tract dissemination was found. Conclusions: Ultrasound-guided PCNB is safe and effective in diagnosing pediatric solid tumors, especially in malignancies. Background: Ultrasound-guided percutaneous core needle biopsy (PCNB) has been used more and more frequently in diagnostics of pediatric solid tumors in our center. It is less invasive than an incisional biopsy. However, reports relating to its reliability in clinical practice are limited. Therefore, we aim to investigate the reliability of this technique in the pediatric population. Methods: A 7-year retrospective study including patients [?] 18 years who underwent ultrasound-guided PCNB in our center was conducted. Children who received PCNB and final surgical treatment were included. Their medical records were reviewed. Final surgical pathological diagnoses were used as the gold standard to assess the diagnostic efficiency of PCNB. Results: A total of 169 children were included in our analysis. 87.0% of patients underwent PCNB for abdominal and pelvic masses. 79.1% of biopsies were performed under local anesthesia. There were 141 malignancies and 28 benign lesions confirmed by surgery. The most common malignancy was neuroblastoma (73), and the most

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Percutaneous guided biopsy for diagnosing suspected primary malignant bone tumors in pediatric patients: a safe, accurate, and cost-saving procedure

Abstract: Percutaneous biopsy is a valid alternative to open biopsy for diagnosing pediatric and young adult primary malignant bone tumors.

Cited by 25 publications

References 29 publications

Generation of patient‐derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas

Generation of patient‐derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas

PET/CT-guided versus CT-guided percutaneous core biopsies in the diagnosis of bone tumors and tumor-like lesions: which is the better choice?

Reliability of Ultrasound-Guided Percutaneous Core Needle Biopsy in Diagnostics of Pediatric Solid Tumors

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