The only commercially available device in the documented institution is the Watchman (Boston Scientific, Marlborough, MA, USA) occluder which is the predominant occluder in China. The single device approach may not always fit the great anatomic variability of the left atrial appendage (LAA). Adequate closure may require more than a single device. The commercially available Watchman device only fits LAAs with a maximum diameter of 30 mm [1-3]. In patients with bilobulated LAA, the one-stop implantation of double Watchman is feasible as reported by a previous study [4]. However, it is unknown whether this approach is feasible in the setting of a single-lobulated LAA with a giant ostium (> 30 mm). Reported herein, is a consecutive case series of patients in whom kissing-Watchman was performed to achieve adequate closure of the single-lobulated LAA with large-ostium. Three out of 100 consecutive patients underwent kissing-Watchman occlusion under the guidance of transesophageal echocardiography (TEE). This experimental procedure was preceded with the patient's acceptance. Before intervention, TEE was performed to exclude thrombi in the LAA. The procedures were performed via femoral access under general anesthesia, and were controlled by the angiography and TEE. At the beginning of the intervention, 5000 units of heparin were given. After transseptal passage, TEE measurement of the LAA diameter at the intended implantation site was performed at four different angles. According to the three cases, the maximal LAA ostia diameters were 35, 36, and 33 mm, respectively.