Percutaneous nerve electrical stimulation for fatigue caused by chemotherapy for cervical cancer

Background: This protocol of systematic review aims to investigate the effectiveness of electrical stimulation (ES) on adverse events (AEs) caused by chemotherapy in patients with cervical cancer (CC). Methods: This systematic review of randomized controlled trials will be identified through searchers of PUBMED, PsycINFO, Scopus, Opengrey, Cochrane Central Register of Controlled Trials, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Allied and Complementary Medicine Database, and Chinese Biomedical Literature Database. All the sources will be searched from the inception to the date of study search ran. Additionally, websites of clinical trials registry and reference lists provided in relevant studies and reviews will also be searched. Two independent reviewers will evaluate the eligibility criteria of all potential literature, extract the data, and determine the risk of bias for each included study. RevMan 5.3 software will be used to pool the data and to conduct a meta-analysis. Results: This systematic review will assess the effectiveness of ES on AEs caused by chemotherapy in patients with CC. Conclusion: The findings of this study may summarize the latest evidence for the ES on AEs following chemotherapy for CC. PROSPERO registration number: PROSPERO CRD42019120191.

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Electrical stimulation on adverse events caused by chemotherapy in patients with cervical cancer

Dou¹,

Zhang²,

Su³

et al. 2019

“…Improper handling of stress response can cause psychological disorders to varying extents. [4,5] Adverse psychological conditions like anxiety, depression and fear can negatively affect psychological and emotional well-being and reduce the quality of survival of patients. [6,7] Therefore, interventions to alleviate negative emotions in patients after cervical cancer surgery are particularly important.…”

Section: Introductionmentioning

confidence: 99%

“…As a kind of stressor, surgical treatment of cervical cancer will, to a large extent, lead to strong stress psychological reactions like anxiety and depression. Improper handling of stress response can cause psychological disorders to varying extents [4,5] . Adverse psychological conditions like anxiety, depression and fear can negatively affect psychological and emotional well-being and reduce the quality of survival of patients [6,7] .…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of mindfulness-based stress reduction intervention on alleviating anxiety and depression in postoperative patients with cervical cancer

Yang

Huang²,

et al. 2022

Background: Surgical treatment for cervical cancer, as a stressor, largely leads to strong psychological reactions to stress like anxiety and depression. Whether mindfulness-based stress reduction (MBSR) can alleviate anxiety and depression in patients after cervical cancer surgery is controversial. Therefore, we aim to perform a meta-analysis involving randomized controlled trials analyzing the effect of MBSR on alleviating anxiety and depression in patients after cervical cancer surgery, thus providing evidence-based medical evidences for nonpharmacological interventions.Methods: Randomized controlled trials analyzing the effect of MBSR on alleviating anxiety and depression in patients after cervical cancer surgery will be searched in online databases, including Cochrane Central Register of Controlled Trials Repositories, PubMed, Embase, Web of Science, Chinese Science Citation Database, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, and Wan Fang Data. After screening eligible studies, we will perform a meta-analysis on the effect of MBSR on alleviating anxiety and depression in patients after cervical cancer surgery.Results: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication.Conclusion: This study will provide reliable evidence-based evidences for the effects of MBSR on alleviating anxiety and depression in patients after cervical cancer surgery.Ethics and dissemination: Ethical approval was not required for this study. The systematic review will be published in a peerreviewed journal, presented at conferences, and shared on social media platforms.

“…Chemotherapy is recognized an effective way during the anti-cancer treatment, while it has greatly improved overall survival in variety types of cancers, also brings side effects, such as chemotherapy-induced nausea and vomiting (CINV), [ 3 , 4 ] chemotherapy-induced diarrhea (CID), [ 5 , 6 ] chemotherapy-induced constipation (CIC), [ 5 ] pain, [ 7 ] and fatigue, [ 8 ] which were greatly interfering the treatment course. Among these toxic side events, chemotherapy-induced gastrointestinal reactions, including CINV, CID and CIC, were the most widely influential and severe symptoms.…”

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of moxibustion for chemotherapy-induced gastrointestinal adverse reaction

Zhang

Dai

et al. 2020

Background: Many cancer patients experience gastrointestinal adverse reaction during chemotherapy. Pharmacological interventions are commonly used to treat chemotherapy-induced gastrointestinal side effects but have various limitations. Clinical trials have indicated that moxibustion may alleviate gastrointestinal dysfunction and improve quality of life (QoL) after chemotherapy. This study aims to assess the efficacy and safety of moxibustion for chemotherapy-induced gastrointestinal adverse reaction through a systematic review and meta-analysis. Methods: All randomized controlled trials (RCTs) related to moxibution targeting chemotherapy-induced gastrointestinal adverse reaction will be searched in online databases, such as PubMed, EMBASE, the Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), the Chinese Scientific Journal Database (VIP Database) and WanFang Database from their inception to May 1, 2020. The primary outcome is the incidence and severity of chemotherapy-related gastrointestinal toxicities (nausea and vomiting, diarrhea and constipation). The secondary outcomes include the quality of life, biological parameters’ alteration, and adverse events. Study selection, data extraction, and assessment of risk of bias will be performed independently by 2 researchers. The Cochrane Collaboration's Review Manager (RevMan 5.3) software will be used to conduct the direct meta-analysis. Results: This study will provide a comprehensive review of the available evidence for the treatment of chemotherapy-induced gastrointestinal adverse reaction with moxibustion. Conclusion: The conclusion of this study will provide evidence to judge whether moxibustion is an effective and safety therapeutic intervention for chemotherapy-induced gastrointestinal adverse reaction. PROSPERO registration number: CRD42020182990.