Permanent transvenous cardiac pacemakers were implanted in 40 dogs. Electrocardiographic diagnoses included persistent atrial standstill (3 dogs), sick sinus syndrome (8 dogs), and high-grade second-degree or third-degree atrioventricular (AV) block (29 dogs). Thirteen dogs were alive and well 4 to 42 months after pacemaker implantation (mean, 16.9 months). The mean and median survival times of the 26 dogs that died or were euthanatized during the study were 17.9 months and 13 months, respectively. Most of these dogs succumbed to problems unrelated to the arrhythmia and pacemaker implant. One dog was lost to follow-up. Complications associated with permanent transvenous pacemaker implantation included lead dislodgement, infection, hematoma formation, skeletal muscle stimulation, ventricular arrhythmia, migration of the pulse generator, and skin erosion. Lead dislodgement was the most common complication, occurring in 7 of 9 dogs paced using untined electrode leads and in 6 of 30 dogs paced using tined leads. Lead dislodgement did not occur in the only dog paced using an actively fixed endocardial lead. It was concluded that permanent transvenous cardiac pacing is a feasible, less traumatic alternative to epimyocardial pacing in dogs, but that successful use of this technique requires careful implantation technique and anticipation of the potential complications. (Journal of Veterinary Internal Medicine 1991; 5:322-331) THE FIRST totally implantable artificial cardiac pacemakers were developed more than 30 years ago.' Since then, the equipment and techniques available to accomplish artificial cardiac pacing have changed dramatially.^-^ One of the most important technologic advances in artificial pacemaker design has been the development of durable pacing and sensing endocardial electrodes (leads) that can be introduced into the heart from a peripheral vein6-* Before the development of permanent transvenous leads, reliable artificial cardiac pacing could only be accomplished by surgical implantation of an epimyocardial electrode. Currently, transvenous