This article discusses the diagnostic accuracy of patient-specific 3D printed models in delineating cardiovascular anatomy and disease, with a focus on a recent paper published in the American Journal of Roentgenology about the accuracy of 3D printed hollow models of visceral aneurysms. Three aspects will be discussed in this review: first, 3D printed physical models are accurate in assessing the sizes and shapes of visceral aneurysms and related arteries; second, a more reliable method was implemented in this study for measurement of the diagnostic accuracy of 3D printed model to further validate the precision of 3D printing technique; and finally, 3D printed models serve as a reliable tool for replicating anatomical structures and pre-surgical simulation of endovascular treatment of aneurysmal disease. Three-dimensional (3D) printing is a rapidly developed technique showing great promise in medicine with increased applications reported in the cardiovascular disease. 1-12 3D printed physical models based on computed tomography (CT) or magnetic resonance imaging (MRI) imaging data show high accuracy in replicating complex anatomic structures of cardiovascular system, ranging from delineation of anatomical details of cardiovascular system to detection of pathologies. 1-9 Furthermore, 3D printed realistic models have been shown to play an important role in pre-surgical planning and simulation of complex cardiovascular disease, in both adult and pediatric patients through clear illustration of cardiac pathologies and facilitation of the simulation. [13][14][15][16][17] Before 3D printed models are recommended for routine clinical applications, it is important to ensure the accuracy of 3D printed models. This is especially important for dealing with cardiovascular disease due to the complexity of cardiovascular anatomy and a variety of cardiovascular diseases, which requires high precision of 3D printed models. Accuracy of patient-specific 3D printed models has been reported in the maxillofacial surgery using anatomic landmarks. [18][19][20] Similarly, good to excellent agreement has been reached between 3D printed models and original source 2D images for dimensional measurements of aortic valve, aortopulmonary artery, and aortic aneurysms. [21][22][23][24][25] However, in a recent study, Ho et al have indicated that the variances in aortic diameter measurements between 3D printed models and 2D contrastenhanced CT images exceeded 1.0 mm, which is beyond the standard deviation of 1.0 mm. 26 This highlights the potential limitations of using anatomic landmarks to measure accuracy of 3D printed hollow models, such as heart models or aneurysmal models. By taking into account both sizes and shapes of the visceral aneurysms, the accuracy of 3D printed hollow models has been validated to further confirm the reliability of 3D printing technology. 27 In their recent study, Shibata et al retrospectively analyzed 11 patients having a total