Percutaneous radiofrequency thermal ablation of renal cell carcinoma: Is it possible a day-hospital treatment?

Carrafiello, Gianpaolo; Laganà, Domenico; Ianniello, Andrea; Mangini, Monica; Fontana, Federico; Cotta, E.; Concollato, Laura; Marconi, A; Recaldini, Chiara; Dionigi, Gianlorenzo; Rovera, Francesca; Boni, Luigi; Cuffari, Salvatore; Fugazzola, Carlo

doi:10.1016/j.ijsu.2008.12.034

Cited by 14 publications

(6 citation statements)

References 45 publications

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“…Although the local recurrence rate was lower for partial nephrectomy than that for ablation therapy [18], surgical resection may cause potential injury to the remaining kidney [19], causing renal dysfunction or even renal failure. Minimally invasive ablation therapy is successfully applied for RCCs treatment and has gained preliminary satisfactory results [20][21][22]. Talenfeld et al [23] retrospectively evaluated T1a lesions treated either with RFA, cryoablation, or MWA, and reported similar oncologic outcomes of total or partial nephrectomy (5-year cancer-specific survival rate: 95-98%); however, less periprocedural complications, reduced 90 days mortality, and a lower risk of long-term renal insufficiency were observed.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of CT-guided microwave ablation for stage T1a renal cell carcinoma in patients with a solitary kidney

Meng

Yang

Jia

et al. 2021

International Journal of Hyperthermia

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of CT-guided microwave ablation for stage T1a renal cell carcinoma in patients with a solitary kidney

Meng

Yang

Jia

et al. 2021

International Journal of Hyperthermia

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“…It has been widely used to treat lung cancer and other types of liver cancers [ 7 ]. MWA as one type of thermal ablation can provide a consistently high intratumoral temperature and ablate large volumes with multiple probes; thus, MWA as a suitable therapeutic technique may improve the treatment efficacy in inoperable SHC [ 15 , 16 ]. However, in clinical use, due to the high puncture resistance, high thermal resistance, and poor thermal conductivity caused by heavy fibrosis and necrosis, the failure rate of MWA in the treatment of SHC is very high.…”

Section: Discussionmentioning

confidence: 99%

CT-Guided Percutaneous Microwave Ablation of Sclerosing Hepatic Carcinoma

Song

Ding

Zhu

2020

Canadian Journal of Gastroenterology and Hepatology

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“…Clinical studies on MWTA of small renal masses and conservative surgery should be then conducted to obtain extensive clinical clarifications and indications on this fascinating technique. Microwaves create a thermal field that is absorbed by surrounding tissues proportionally to the tissue water content (19). Thus, tissues with greater water content absorb more energy and produce heat, while tissues with lower water content produce less heat and propagate microwaves (20).…”

Section: Discussionmentioning

confidence: 99%

Microwave-induced thermoablation with Amica-probe is a safe and reproducible method to treat solid renal masses: Results from a phase I study

et al. 2012

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Abstract. Microwave thermal ablation (MWTA) could be considered in the future for treating small solid renal masses. The aim of the present study was to determine both the tolerability of the new Amica-probe applicator-induced MWTA used in vivo on patients with solid renal masses and the effects of heating on renal tumors and normal renal parenchyma. Fourteen patients with renal masses eligible for open radical nephrectomy were enrolled in this phase I study. All patients underwent MWTA of renal masses during the open surgery procedure before clamping of renal vascular pedicle. The effects of MWTA on patients' coagulation and tumor/renal vasculature were investigated. The histological effects of MWTA on the tumor and intralesional vital tumor cell skipping were also evaluated. The MWTA-induced lesion diameters were measured to calculate both the overall ablation volume and the lesion sphericity index (SI). The Clavien-Dindo classification was used. In all patients the RENAL score was 9.4 (8-12) and the Charlson comorbidity index was 4.8 (3-7). MWTA-induced lesion size was 44.14 mm (±22.59). Mean SI was 1.08 (±0.2). No significant differences among coagulation clinical parameters were found. No local bleeding after MWTA treatment was reported. According to the ClavienDindo classification, there were two grade II perioperative complications due to the tumor extent but not related with the MWTA treatment. No residual vital tumor cells inside the MWTA-induced lesions were found. Telephone interview at 27.4 (±4.2) months mean follow-up did not find any long-term adverse events due to previous MWTA treatment. AmicaProbe applicator-induced MWTA is a safe and reproducible method to treat solid renal masses. IntroductionPrevalence of small solid renal masses in adult population recently increased probably due to the large number of people that daily undergo preventive diagnostic investigations such as ultrasonography and computed tomography (CT) scan for unrelated symptoms, resulting in incidental tumor detection (1). Patients' comorbidities, such as cardiovascular or respiratory diseases, could represent limiting factors for planning adequate subsequent surgical approaches although conservative laparoscopy surgery is now considered the gold standard treatment, particularly for tumors <3-4 cm (2). Minimally invasive procedures, such as cryoablation (CryA) and radiofrequency ablation (RFA), have been recently proposed by different authors as alternative methods of treatment to conservative surgery with satisfactory results in terms of perioperative complications such as hemorrhage episodes or metabolic problems related to prolonged period of general anaesthesia (3). Some doubts remain on the efficacy of these methods on tumor complete eradication due to the high prevalence of tumor local recurrences due to persistent vital tumor cells in the context of the ablated tissue (tumor skipping) (4). Both CryA and RFA are based on the application of physical means (cold and heat respectively) at the centre of the lesion to induce...

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Percutaneous radiofrequency thermal ablation of renal cell carcinoma: Is it possible a day-hospital treatment?

Abstract: Preliminary results with RFA of RCC are promising. Radiofrequency thermal ablation could prove to be a useful treatment for patients who are unsuitable for surgery; in this study we demonstrate the feasibility of the treatment in day-hospital for selected patients.

Cited by 14 publications

References 45 publications

Efficacy and safety of CT-guided microwave ablation for stage T1a renal cell carcinoma in patients with a solitary kidney

Efficacy and safety of CT-guided microwave ablation for stage T1a renal cell carcinoma in patients with a solitary kidney

CT-Guided Percutaneous Microwave Ablation of Sclerosing Hepatic Carcinoma

Microwave-induced thermoablation with Amica-probe is a safe and reproducible method to treat solid renal masses: Results from a phase I study

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