PERFIL FITOQUÍMICO, SUSCEPTIBILIDADE ANTIBACTERIANA E CAPACIDADE ANTIOXIDANTE DAS FOLHAS DE Croton urucurana Baillon (Euphorbiaceae)

Abstract

Croton urucurana Baillon, popularly known as "sangria d'água", belongs to the Euphorbiaceae family. The species has a great importance in folk medicine as antibacterial, anti-inflammatory, antiseptic, antiviral, antidiarrheal, intestinal antisecretory and cicatrizant remedies. The objective of this study was to verify the presence, in the aqueous, ethanolic and hydroalcoholic extracts, of secondary metabolites (alkaloids, anthraquinones, steroids/triterpenoids, flavonoids, glycosides, saponins and tannins), analyze the inhibition of bacteria Staphylococcus aureus ATCC 25923 and Salmonella thyphimurium ATCC 14028 growth, and evaluate the antioxidant activity by the DPPH method. Considering the phytochemical profile, the best extract was the aqueous; the bacteria susceptibility was inhibited with the ethanolic extract; and the extract with the highest antioxidant activity was the hydroalcoholic, presenting IC 50 1.3 μg/ mL. It was concluded that the extracts of Croton urucurana Baillon show interesting results and that further investigations must be carried out for the better elucidation of its benefits. Keywords:Croton urucurana Baillon; phytochemical; antioxidant; antibacterial; extract. RESUMOCroton urucurana Baillon, espécie conhecida popularmente como "sangria d'água", pertence à família Euphorbiaceae, possui grande importância na medicina popular, a qual lhe atribui propriedades antibacterianas, anti-inflamató-rias, antissépticas, antivirais, antidiarreicas, antissecretória intestinal e cicatrizante. Os objetivos deste estudo foram verificar a presença, nos extratos aquoso, etanólico e hidroalcoólico, de metabolitos secundários (alcaloides, antraquinonas, esteroides/triterpenoides, flavonoides, glicosídeos, saponinas e taninos), analisar a inibição do crescimento das bactérias Staphylococcus aureus ATCC 25923 e Salmonella thyphimurium ATCC 14028, e verificar a atividade antioxidante através do método DPPH. Para o perfil fitoquímico o melhor extrato foi o aquoso, quanto à susceptibilidade bacteriana, houve inibição com o extrato etanólico e o extrato com a maior atividade antioxidante foi o hidroalcóolico, apresentando IC 50 1,3 μg/mL. Considerando os resultados obtidos no estudo, foi possível concluir que os extratos da Croton urucurana Baillon apresentam resultados interessantes e que mais investigações devem ser realizadas para a elucidação aprimorada dos seus benefícios.

Extracts of native forest species of the southern amazon in the control of Aphis craccivora koch (Hemiptera: aphididae)

“…The type of solvent and the concentration are relevant factors that can influence the extraction of metabolites (Andreo and Jorge 2006). Silva et al (2017a) verified that there were differences in the results when they compared different types of extracts (solvent: distilled water; alcoholic solvent: absolute ethanol; and hydroalcoholic solvent: water and absolute ethanol (1: 1)).…”

Influence of the capuchin hydroethanolic extract (Tropaeolum majus L.) on the stability of ketoconazole

“…Light and oxygen directly interfere with the stability of substances because they form free radicals that give rise to oxidation-reduction reactions, causing changes in the active substances. These products should primarily be stored in low light environments and with the addition of antioxidants (Brasil, 2004;Silva et al, 2017). Some stability problems are observed in formulations with the drug ketoconazole.…”

ANTIOXIDANT ACTIVITY AND TOTAL PHENOL, FLAVONOID AND TANNIN CONTENTS OF Croton floribundus AND Croton urucurana

“…Chemically, Croton stands out for the production of diterpenes (MACIEL et al, 2006;PIZZOLATTI et al, 2013). Other secondary metabolites include triterpenes, flavonoids, alkaloids and phenylpropanoids (CANELO et al, 2017;SANTOS et al, 2015;RAVANELLI et al, 2016;ALVES et al;. A broad biological action is attributed to these metabolites and to extracts and/or fractions obtained from species of the genus, such as antioxidant, cytotoxic, mutagenic and antimicrobial activities (AQUINO et al, 2017;SANTOS et al, 2015;ALMEIDA et al, 2019).…”