Perfluoroalkyl acids (PFAAs) in the aquatic food web of a temperate urban lake in East China: Bioaccumulation, biomagnification, and probabilistic human health risk

Chu, Kejian; Lü, Ying; Hua, Zulin; Liu, Yuanyuan; Ma, Yahong; Gu, Li; Chang, Guiran; Yu, Liang; Wang, Yifan

doi:10.1016/j.envpol.2021.118748

Cited by 29 publications

(6 citation statements)

References 60 publications

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“…In aquatic environments, PFAAs with shorter chain length tend to enrich in water. , In solid media, such as the surface of soil particles, sediment, aquatic suspended particles and the tissues of aquatic organisms, , PFAAs’ translocation factor (TF) is also positively correlated with the chain length, which is often due to the hydrophobicity of PFAAs . However, other studies showed that the hydrophobicity existed only in long-chain PFAAs.…”

Section: Discussionmentioning

confidence: 99%

Iron–Nitrogen Amendment Reduced Perfluoroalkyl Acids’ Phyto-Uptake in the Wheat–Soil Ecosystem: Contributions of Dissolved Organic Matters in Soil Solution and Root Extracellular Polymeric Substances

Wu,

Hua,

2023

Environ. Sci. Technol.

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Understanding the mechanisms underlying perfluoroalkyl acids (PFAAs) translocation, distribution, and accumulation in wheat–soil ecosystems is essential for agricultural soil pollution control and crop ecological risk assessment. This study systematically investigated the translocation of 13 PFAAs under different iron and nitrogen fertilization conditions in a wheat–soil ecosystem. Short-chain PFAAs including PFBA, PFPeA, PFHxA, and PFBS mostly accumulated in soil solution (10.43–55.33%) and soluble extracellular polymeric substances (S-EPS) (11.39–14.77%) by the adsorption to amino- (−NH2) and hydroxyl (−OH) groups in dissolved organic matter (DOM). Other PFAAs with longer carbon chain lengths were mostly distributed on the soil particle surface by hydrophobic actions (74.63–94.24%). Iron–nitrogen amendments triggered (p < 0.05) soil iron–nitrogen cycling, rhizospheric reactive oxygen species fluctuations, and the concentration increases of −NH2 and −OH in the DOM structure. Thus, the accumulation capacity of PFAAs in soil solution and root EPS was increased. In sum, PFAAs’ translocation from soil particles to wheat root was synergistically reduced by iron and nitrogen fertilization through increased adsorption of soil particles (p < 0.05) and the retention of soil solution and root EPSs. This study highlights the potential of iron–nitrogen amendments in decreasing the crop ecological risks to PFAAs’ pollution.

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Section: Discussionmentioning

confidence: 99%

Iron–Nitrogen Amendment Reduced Perfluoroalkyl Acids’ Phyto-Uptake in the Wheat–Soil Ecosystem: Contributions of Dissolved Organic Matters in Soil Solution and Root Extracellular Polymeric Substances

Wu,

Hua,

2023

Environ. Sci. Technol.

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“…1 Due to its high bioaccumulation, multiple organ toxicity, and nondegradation, PFOS has been listed in Annex B of the Stockholm Convention on Persistent Organic Pollutants (POPS). 2,3 PFOS residues in food and the environment can easily enter the food chain and become enriched in animals at higher trophic levels. 4 At present, high concentrations of PFOS can be detected in plants and animals around the world.…”

Section: Introductionmentioning

confidence: 99%

“…Perfluorooctanesulfonate (PFOS), as a fluorine-containing organic compound, has been widely used over the years as an antifouling agent as well as in refrigerant, packaging material, and cookware due to its hydrophobic and oleophobic properties . Due to its high bioaccumulation, multiple organ toxicity, and nondegradation, PFOS has been listed in Annex B of the Stockholm Convention on Persistent Organic Pollutants (POPS). , PFOS residues in food and the environment can easily enter the food chain and become enriched in animals at higher trophic levels . At present, high concentrations of PFOS can be detected in plants and animals around the world. , PFOS exposure can cause damage to many parts of the body in a variety of ways in animal models.…”

Section: Introductionmentioning

confidence: 99%

Cannabidiol Alleviates Perfluorooctanesulfonic Acid-Induced Cardiomyocyte Apoptosis by Maintaining Mitochondrial Dynamic Balance and Energy Metabolic Homeostasis

Wang

Luo

et al. 2023

J. Agric. Food Chem.

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Perfluorooctanesulfonic acid (PFOS), a fluorine-containing organic compound, can be widely detected in the environment and living organisms. Accumulating evidence has shown that PFOS breaks through different biological barriers resulting in cardiac toxicity, but the underlying molecular mechanisms remain unclear. Cannabidiol (CBD) is a nonpsychoactive cannabinoid without potential adverse cardiotoxicity and has antioxidant and anti-inflammatory properties that reduce multiorgan damage and dysfunction. For these reasons, the aim of this study was to research how PFOS caused heart injury and whether CBD could attenuate PFOS-induced heart injury. Mice were fed PFOS (5 mg/kg) and/or CBD (10 mg/kg) in vivo. In vitro, H9C2 cells were intervened with PFOS (200 μM) and/or CBD (10 μM). After PFOS exposure, oxidative stress levels and the mRNA and protein expression of apoptosis-related markers increased distinctly, accompanied by mitochondrial dynamic imbalance and energy metabolism disorders in mouse heart and H9C2 cells. Moreover, terminal deoxynucleotidyl transferase dUTP nick end labeling staining, acridine orange/ethidium bromide staining and Hoechst 33258 staining signaled that the number of apoptotic cells increased after exposure to PFOS. Noteworthy, CBD simultaneous treatment alleviated a series of damages caused by PFOS-mediated oxidative stress. Our results demonstrated that CBD could alleviate PFOS-induced mitochondrial dynamics imbalance and energy metabolism disorder causing cardiomyocyte apoptosis by improving the antioxidant capacity, suggesting that CBD may represent a novel cardioprotective strategy against PFOS-induced cardiotoxicity. Our findings facilitate the understanding of the cardiotoxic effects of PFOS and the important role of CBD in protecting cardiac health.

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“…5 Continuous and large-scale application has made PFAAs ubiquitous in global environmental media. They bioaccumulate in living organisms and biomagnify along the food chain, 6,7 eliciting multiple toxicity effects including developmental toxicity and reproductive toxicity on organisms. 8,9 Moreover, it was reported that PFAAs also had potential health risks and adverse effects, and the related issues included metabolic syndrome, kidney disease, and thyroid dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Characteristics, source apportionment and health risk assessment of perfluoroalkyl acids in typical drinking water sources of eastern China

Liu

Jia

et al. 2023

Environ. Sci.: Water Res. Technol.

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Perfluoroalkyl acids (PFAAs) in the aquatic food web of a temperate urban lake in East China: Bioaccumulation, biomagnification, and probabilistic human health risk

Cited by 29 publications

References 60 publications

Iron–Nitrogen Amendment Reduced Perfluoroalkyl Acids’ Phyto-Uptake in the Wheat–Soil Ecosystem: Contributions of Dissolved Organic Matters in Soil Solution and Root Extracellular Polymeric Substances

Iron–Nitrogen Amendment Reduced Perfluoroalkyl Acids’ Phyto-Uptake in the Wheat–Soil Ecosystem: Contributions of Dissolved Organic Matters in Soil Solution and Root Extracellular Polymeric Substances

Cannabidiol Alleviates Perfluorooctanesulfonic Acid-Induced Cardiomyocyte Apoptosis by Maintaining Mitochondrial Dynamic Balance and Energy Metabolic Homeostasis

Characteristics, source apportionment and health risk assessment of perfluoroalkyl acids in typical drinking water sources of eastern China

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