Perfluorocarbon‐Loaded Hollow Bi<sub>2</sub>Se<sub>3</sub> Nanoparticles for Timely Supply of Oxygen under Near‐Infrared Light to Enhance the Radiotherapy of Cancer

Song, Guosheng; Liang, Chao; Yi, Xuan; Zhao, Qi; Cheng, Liang; Yang, Kai; Liu, Zhuang

doi:10.1002/adma.201504617

Cited by 541 publications

(406 citation statements)

References 57 publications

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“…219-222 Although in this review article we have discussed various strategies based on NPs for efficient MRI, there has been no literature report on hypoxia-responsive NPs as MRI CAs except on several chemical complexes for hypoxia-related MRI such as T 1 or T 2 CAs, 223 19 F-based probes, 224 and CEST probes. 86 We believe that research on this subject is likely already in progress, and the NPs that respond to hypoxia via , for example, valency change, size/morphology variation, assembly, and disassembly for enhanced MRI, will likely play multiple roles in accurate and noninvasive delineation of hypoxic areas, more precise and effective treatment, and real-time and noninvasive monitoring of therapeutic efficacy.…”

Section: Discussionmentioning

confidence: 99%

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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Magnetic resonance imaging (MRI) is a highly valuable non-invasive imaging tool owing to its exquisite soft tissue contrast, high spatial resolution, lack of ionizing radiation, and wide clinical applicability. Contrast agents (CAs) can be used to further enhance the sensitivity of MRI to obtain information-rich images. Recently, extensive research efforts have been focused on the design and synthesis of high-performance inorganic nanoparticle-based CAs to improve the quality and specificity of MRI. Herein, the basic rules, including the choice of metal ions, effect of electron motion on water relaxation, and involved mechanisms, of CAs for MRI have been elucidated in detail. In particular, various design principles, including size control, surface modification (e.g. organic ligand, silica shell, and inorganic nanolayers), and shape regulation, to impact relaxation of water molecules have been discussed in detail. Comprehensive understanding of how these factors work can guide the engineering of future inorganic nanoparticles with high relaxivity. Finally, we have summarized the currently available strategies and their mechanism for obtaining high-performance CAs and discussed the challenges and future developments of nanoparticulate CAs for clinical translation in MRI.

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Section: Discussionmentioning

confidence: 99%

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

et al. 2017

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“…The use of perfluorocarbons has been recognized as a useful strategy to improve oxygenation level of solid tumours, and thus increase their vulnerability to therapeutic methods during and after treatments, such as ionizing radiation 134, 169 and chemical drugs. 170, 173, 176, 177 Specifically, oxygen-favoring PDT would deplete oxygenation level through photochemical consumption and occlusion of blood vessels.…”

Section: Oxygen Self-supplementmentioning

confidence: 99%

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

et al. 2016

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Reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of synergistic effects between light, photosensitizer (PS) and oxygen, which greatly favor the spatiotemporal control of the treatment. This procedure has also evoked several unresolved challenges at different levels including (i) limited penetration depth of light restricts traditional PDT to only superficial tumours; (ii) oxygen reliance deprives PDT treatment of hypoxic tumours; (iii) light could complicate the phototherapeutic outcomes due to the concurrent heat generation; (iv) specific delivery of PSs to sub-cellular organelles for exerting effective toxicity remains an issue; and (v) side effects by undesirable white-light activation and self-catalysation of traditional PSs. Recent advances in nanotechnology and nanomedicine have provided new opportunities to develop ROS-generating systems through photodynamic or non-photodynamic procedures while tackling the challenges of current PDT approaches. In this review, we summarize the current status and discuss the possible opportunities of ROS generation for cancer therapy. We hope this review will spur pre-clinical research and clinical practice for ROS-mediated tumour treatment.

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“…Therefore, several Bi-based nanomaterials, such as Bi 2 S 3 nanodots, 32 Bi 2 S 3 nanorods 33 and Bi 2 Se 3 NPs with different morphologies, [34][35][36][37][38] have been proposed as X-ray CT contrast agents and radio-/photothermal therapy sensitizing agents. Compared with orthorhombic Bi 2 S 3 , the topological insulator Bi 2 Se 3 has a two-dimensional layered rhombohedral structure with a unique surface electronic state 39,40 and has aroused increasing interest in biomedical applications due to its multifunctionality and good biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

et al. 2017

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An efficient radiotherapeutic agent is synthesized using ultrathin two-dimensional 30-nm-wide and 2-nm-thick Bi 2 Se 3 nanosheets (NSs) as a radiosensitizer. Chitosan (CS) and RGD peptide are employed to enhance the radiotherapy efficiency and biocompatibility. The Bi 2 Se 3 -CS-RGD NSs exhibit excellent targeting ability to αvβ3 integrin-overexpressing cancer cells and potent radiosensitization efficiency with high stability. Detailed in vitro experiments show that the Bi 2 Se 3 -CS-RGD NSs enhance the sensitivity of HeLa cells to X-ray-induced cell death by inhibiting TrxR activities and activating downstream reactive oxygen species-mediated signaling pathways. In vivo experiments using intravenous or intratumor injection demonstrate that the Bi 2 Se 3 -CS-RGD NSs are more efficient tumor growth inhibitors compared to bare Bi 2 Se 3 NSs. The multifunctionality of the NSs enables the use of photoacoustic imaging and magnetic resonance imaging to examine their targeting ability and therapeutic effects, respectively. In addition, the RGD-decorated Bi 2 Se 3 NSs show much better in vivo biocompatibility and can be efficiently expelled from the body after 48 h post injection. This study reveals an effective and safe theranostic agent for next-generation cancer radiotherapy.

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Perfluorocarbon‐Loaded Hollow Bi₂Se₃ Nanoparticles for Timely Supply of Oxygen under Near‐Infrared Light to Enhance the Radiotherapy of Cancer

Cited by 541 publications

References 57 publications

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

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Perfluorocarbon‐Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near‐Infrared Light to Enhance the Radiotherapy of Cancer

Cited by 541 publications

References 57 publications

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Decorated ultrathin bismuth selenide nanosheets as targeted theranostic agents for in vivo imaging guided cancer radiation therapy

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Perfluorocarbon‐Loaded Hollow Bi₂Se₃ Nanoparticles for Timely Supply of Oxygen under Near‐Infrared Light to Enhance the Radiotherapy of Cancer