2012
DOI: 10.1097/ede.0b013e31824cb93b
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Perfluorooctanoic Acid Exposure and Pregnancy Outcome in a Highly Exposed Community

Abstract: Background We assessed the association between perfluorooctanoic acid (PFOA) and pregnancy outcome in an area with elevated exposure to PFOA from drinking water contaminated by chemical plant releases. Methods Serum PFOA was measured and reproductive and residential histories were obtained in 2005 – 2006. We estimated serum PFOA levels at the time of pregnancy for 11,737 pregnancies occurring between 1990 and 2006 based on historical information on PFOA releases, environmental distribution, pharmacokinetic m… Show more

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Cited by 140 publications
(153 citation statements)
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“…No association was seen between elevated PFOA exposure and pregnancy outcomes, including miscarriage, stillbirth or birth defects, lowered birth weight [288,289], but for some suggestion of early preterm birth and possibly fetal growth restriction [290]. No association of PFOA with birth defects was found but further investigation was recommended for the brain [291].…”
Section: More Exposed Populationsmentioning
confidence: 85%
“…No association was seen between elevated PFOA exposure and pregnancy outcomes, including miscarriage, stillbirth or birth defects, lowered birth weight [288,289], but for some suggestion of early preterm birth and possibly fetal growth restriction [290]. No association of PFOA with birth defects was found but further investigation was recommended for the brain [291].…”
Section: More Exposed Populationsmentioning
confidence: 85%
“…They found a statistically significant association between prenatal PFOA exposure and low birth weight, but no effect of PFOS exposure (Fei et al, 2007). An American study conducted in areas with PFOA contaminated drinking water found no significant association between prenatal PFOA exposure and pregnancy outcome (preterm birth, gestational age, birth weight, still birth) even though the women had high PFOA exposure levels (PFOA mean, 31.0 ng/mL) (Darrow, Stein, & Steenland, 2013;Savitz et al, 2012). Similarly, two…”
Section: Discussionmentioning
confidence: 99%
“…The DNBC included serum samples collected from 1400 pregnant women and found an association between PFOA, but not PFOS, exposure and low birth weight (Fei et al 2007). A recent American study in a population exposed to PFOA-contaminated drinking water has found no association with pregnancy outcome (preterm birth, gestational age, birth weight, and stillbirth; Savitz et al 2012), similar to the findings reported by Monroy et al (2008). However, Savitz et al estimated pregnancy exposure levels by extrapolation from later samples and Monroy et al (2008) included only 101 women.…”
Section: Discussionmentioning
confidence: 99%