Perfluorooctanoic acid (PFOA) changes nutritional compositions in lettuce (Lactuca sativa) leaves by activating oxidative stress

Li, Pengyang; Xiao, Zhiyong; Xie, Xiaocan; Li, Zhifang; Yang, Hongju; Ma, Xin; Sun, Jiangnan; Li, Jiuyi

doi:10.1016/j.envpol.2021.117246

Cited by 25 publications

(3 citation statements)

References 59 publications

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“…PFBA induced significant oxidative stress even at the lowest treatment group of 100 pg/L ( Figure 4 a). Both SOD and CAT activities were also depressed in all treatment groups, consistent with studies showing inhibition of superoxidase dismutase (SOD) and catalase (CAT) activity [ 17 , 18 , 30 , 31 ]. Surprisingly, neither of these genes were downregulated in gene expression analysis, indicating that PFBA either leads to enhanced degradation of the enzymes after translation of the gene transcripts or is a direct inhibitor of these enzymes.…”

Section: Discussionsupporting

confidence: 87%

“…The BADH enzyme catalyzes the production of glycine betaine, which is an essential osmotic protectant in plants in response to abiotic stressors such as drought and salinity [ 40 , 41 ]. The very high expression of this gene suggests that the plants utilized glycine betaine in a non-enzymatic stress-response pathway, as was observed with other PFAS studies such as non-enzymatic ROS quenching in lettuce [ 19 , 30 ]. The role of alkaloids as secondary antioxidant molecules in plants in response to abiotic stress is also well established [ 20 , 30 , 42 , 43 , 44 , 45 ].…”

Section: Discussionsupporting

confidence: 62%

“…The very high expression of this gene suggests that the plants utilized glycine betaine in a non-enzymatic stress-response pathway, as was observed with other PFAS studies such as non-enzymatic ROS quenching in lettuce [ 19 , 30 ]. The role of alkaloids as secondary antioxidant molecules in plants in response to abiotic stress is also well established [ 20 , 30 , 42 , 43 , 44 , 45 ]. Thus, the enriched isoquinoline alkaloid biosynthesis and tropane piperidine and pyridine biosynthesis pathways in both the 100 ng/L and 1 mg/L groups may also represent a non-enzymatic oxidative stress response.…”

Section: Discussionsupporting

confidence: 62%

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Perfluorobutanoic Acid (PFBA) Induces a Non-Enzymatic Oxidative Stress Response in Soybean (Glycine max L. Merr.)

Omagamre

Mansourian

Liles

et al. 2022

IJMS

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Short-chain perfluoroalkyl substances (PFAS) are generally considered to be of less environmental concern than long-chain analogues due to their comparatively shorter half-lives in biological systems. Perfluorobutanoic acid (PFBA) is a short-chain PFAS with the most root–shoot transfer factor of all PFAS. We investigated the impact of extended exposure of soybean plants to irrigation water containing environmentally relevant (100 pg–100 ng/L) to high (100 µg–1 mg/L) concentrations of PFBA using phenotypical observation, biochemical characterization, and transcriptomic analysis. The results showed a non-monotonous developmental response from the plants, with maximum stimulation and inhibition at 100 ng/L and 1 mg/L, respectively. Higher reactive oxygen species and low levels of superoxide dismutase (SOD) and catalase (CAT) activity were observed in all treatment groups. However transcriptomic analysis did not demonstrate differential expression of SOD and CAT coding genes, whereas non-enzymatic response genes and pathways were enriched in both groups (100 ng/L and 1 mg/L) with glycine betaine dehydrogenase showing the highest expression. About 18% of similarly downregulated genes in both groups are involved in the ethylene signaling pathway. The circadian rhythm pathway was the only differentially regulated pathway between both groups. We conclude that, similar to long chain PFAS, PFBA induced stress in soybean plants and that the observed hormetic stimulation at 100 ng/L represents an overcompensation response, via the circadian rhythm pathway, to the induced stress.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 62%

Section: Discussionsupporting

confidence: 62%

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Perfluorobutanoic Acid (PFBA) Induces a Non-Enzymatic Oxidative Stress Response in Soybean (Glycine max L. Merr.)

Omagamre

Mansourian

Liles

et al. 2022

IJMS

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Phytotoxicity of 6PPD and its oxidized product 6PPD‐Q on pakchoi (Brassica rapa L. ssp. chinensis)

Liu,

Yu,

et al. 2024

Land Degrad Dev

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N‐(1,3‐dimethylbutyl)‐N′‐phenyl‐p‐phenylenediamine (6PPD) and N‐(1,3‐Dimethylbutyl)‐N′‐phenyl‐p‐phenylenediamine‐quinone (6PPD‐Q) are the derivatives of tire wear particles (TWPs) that can enter the agricultural environment. Their negative consequences on the agricultural environment remain unknown, particularly their toxic effects on edible plants. In this experiment, the toxicity of different concentrations of 6PPD and 6PPD‐Q on pakchoi (Brassica rapa L. ssp. chinensis) was explored by hydroponics. The results revealed that seed germination was inhibited by 6PPD and 6PPD‐Q to various degrees. However, we observed an increase in the fresh weight of pakchoi seedling. Environmental concentration (1 μg L−1) of 6PPD and 6PPD‐Q significantly increased ROS levels and caused changes in antioxidant enzyme activities. The MDA content of pakchoi was significantly elevated under 6PPD‐Q treatment, indicating severe oxidative damage. These results demonstrated the phytotoxicity induced by 6PPD and 6PPD‐Q, which is of great significance for assessing their potential ecological risks in the environment.

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Effects of physicochemical properties and co-existing zinc agrochemicals on the uptake and phytotoxicity of PFOA and GenX in lettuce

Wang

Zhang

Lamichhane³

et al. 2023

Environ Sci Pollut Res

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Perfluorooctanoic acid (PFOA) changes nutritional compositions in lettuce (Lactuca sativa) leaves by activating oxidative stress

Cited by 25 publications

References 59 publications

Perfluorobutanoic Acid (PFBA) Induces a Non-Enzymatic Oxidative Stress Response in Soybean (Glycine max L. Merr.)

Perfluorobutanoic Acid (PFBA) Induces a Non-Enzymatic Oxidative Stress Response in Soybean (Glycine max L. Merr.)

Phytotoxicity of 6PPD and its oxidized product 6PPD‐Q on pakchoi (Brassica rapa L. ssp. chinensis)

Effects of physicochemical properties and co-existing zinc agrochemicals on the uptake and phytotoxicity of PFOA and GenX in lettuce

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