Perforating dermatosis in a patient receiving azathioprine

Abstract

Azathioprine (AZA) is an imidazole derivative of mercaptopurine. It antagonizes purine metabolism, and it may inhibit synthesis of DNA, RNA, and proteins. The 6-thioguanine nucleotides appear to mediate the majority of AZAs immunosuppressive and toxic effects. While cutaneous adverse side-effects are not uncommon, perforating dermatosis has not been reported in association to AZA. We speculate that immunological disorders induced by AZA in susceptible individuals could be related to perforating dermatosis.

Transepidermal elimination of mucin is a very common but not yet reported phenomenon in digital myxoid cysts: a study of 35 cases

“…The nature of these elements varies in literature. Examples include pilomatricomas, follicular cysts, granuloma annulare, elastic fibers, collagen, leishmanias, foreign‐body type granulomas, carcinomatous cells or amyloids…”