Perforating folliculitis: Report of a case in an HIV-infected man

Rubio, F.A.; Pinto, Pedro Herranz; Robayna, G; Peña, José M.; Contreras, F.; Casado, Mariano

doi:10.1016/s0190-9622(99)70470-6

Cited by 25 publications

(11 citation statements)

References 14 publications

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“…Chronic viral infections have also been associated with APD, namely HIV infection and chronic viral hepatitis. 5,6,13,[26][27][28] Moreover, protease inhibitors, including telaprevir and indinavir, have been implicated in its development as these drugs can elicit pruritus. 26,29 Interestingly, in the present study, all patients with HIV infection presented in the setting of AIDS.…”

Section: Discussionmentioning

confidence: 99%

Acquired perforating dermatosis: clinicopathologic study of a 10‐year period at a tertiary teaching hospital

et al. 2019

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Background Acquired perforating dermatosis (APD) comprises an uncommon group of skin disorders that develop in adulthood in association with systemic diseases. The aim of this study was to characterize clinicopathologic features and treatment outcomes in a series of patients diagnosed with APD. Methods Retrospective study of all patients diagnosed with an APD over a 10‐year period (2009–2018) at a tertiary teaching hospital in Lisbon, Portugal. Results Fifty‐seven patients with APD were identified. Thirty‐five patients presented lesions in multiple anatomic areas (61.4%), and the lower limbs were the most common location. Forty‐six patients reported pruritus (80.7%), which was classified as severe in 21 of them (36.8%). An underlying systemic disease was identified in 53 patients (93.0%). Diabetes mellitus (DM) and chronic kidney disease (CKD) were the most common associated systemic diseases, but psychiatric disorders, malignancies, and chronic infections were present in a significant number of patients. The combination of topical steroids with antihistamines was the most prescribed initial treatment, but only 37.8% of the patients had a complete response. Acitretin, systemic steroids, and phototherapy were the treatments associated with the best outcome. Conclusion Acquired perforating dermatosis can be associated with many systemic disorders that have pruritus as a common factor. Chronic viral infections and an occult malignancy should be sought, particularly in the absence of DM and CKD. The management of APD is challenging and is best achieved with the control of the underlying systemic diseases.

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Section: Discussionmentioning

confidence: 99%

Acquired perforating dermatosis: clinicopathologic study of a 10‐year period at a tertiary teaching hospital

et al. 2019

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“…Acquired perforating dermatosis has also been reported in association with a wide variety of other systemic disorders (Table 3). [2][3][4][5][6][7][8][9][30][31][32][33][34][35][36][37][38][39] However, most of the reported patients had also DM and/or CRF. Only in cases with lymphomas, 2,3 pancreas carcinoma, 31 hypothyroidism, 4 myelodysplastic syndrome 33 and AIDS 36 there was no DM and/or CRF.…”

Section: Discussionmentioning

confidence: 99%

Acquired perforating dermatosis: clinicopathological features in twenty‐two cases

Saray

Seckın

Bilezikçi

2006

Acad Dermatol Venereol

168

197

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Background The term of acquired perforating dermatosis (APD) comprises the perforating dermatoses occurring in adult patients. Clinical and histological features of the disease are not uniform, and may resemble any of the four classic perforating disorders: elastosis perforans serpiginosa, reactive perforating collagenosis, perforating folliculitis or Kyrle's disease. Chronic renal failure and/ or diabetes mellitus usually accompany this skin disease. Objective The aim of this study was to delineate the clinical and histopathological features of acquired perforating dermatosis and to investigate the potential relationship between this disease and associated conditions. Methods Twenty-two patients with acquired perforating dermatosis were enrolled in this study. Clinical findings of acquired perforating dermatosis and the spectrum of associated diseases were investigated. Haematoxylin and eosin sections were re-examined, and immunohistochemical stainings (elastic van Gieson and Masson trichrome stains) and periodic acid-Schiff stain were also used for histopathological evaluation. Results Different clinical types of lesions resembling reactive perforating collagenosis, perforating folliculitis or Kyrle's disease were observed. Histopathological features were consistent with any of the four types of perforating dermatoses. Most of the patients (86.4%) had at least one systemic disease. Chronic renal failure (72.7%) and diabetes mellitus (50%) were the most commonly associated conditions. Most of the patients with diabetes mellitus (90.9%) had chronic renal failure due to diabetic nephropathy. All of the patients with chronic renal failure were on dialysis treatment. The other associated conditions were hepatitis (27.3%), anti-HCV Ab-positivity (13.6%), hypothyroidism (9.1%) and tuberculosis lymphadenitis (4.5%). Of the 22 patients, 13.6% were otherwise healthy, and 9.1% were renal transplant recipients. Conclusion Clinicopathological findings of our study indicate that the cases with APD represent the broad spectrum of perforating disorders rather than the variants of the same disease. Although APD is frequently associated with diabetes mellitus and chronic renal failure, this skin disorder may also develop in patients with other systemic disorders, and in those without any medical problems. This skin disease is probably linked to dialysis treatment in patients with chronic renal failure due to diabetes mellitus or other causes.

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“…ARPC is often associated with diabetes mellitus and chronic renal failure 1–3 . Recently, ARPC has been reported to occur with other diseases such as atopic dermatitis, 4 AIDS, 5 scabies 6 and malignancies, however, ARPC associated with dermatomyositis has never been reported in English and Japanese language published work 7 …”

mentioning

confidence: 99%

“…ARPC sporadically occurs in adults; however, it is frequently associated with systemic diseases, especially chronic renal failure and diabetes mellitus 1–3 . Other underlying conditions include HIV infection, 5 liver diseases and malignancies. Several pruritic diseases such as scabies, 6 insect bites, 9 atopic dermatitis 4 and prurigo have been also reported.…”

mentioning

confidence: 99%