Performance and characteristics evaluation of a sodium hyaluronate-based microneedle patch for a transcutaneous drug delivery system

Recent insights into cutaneous immunization: How to vaccinate via the skin

“…The most common technique for cutaneous vaccination involves the direct coating of antigen onto solid microneedles [15][16][17]. However, dissolving microneedles have also been extensively investigated [130,131]. The aim of this technology as regards vaccination is to pierce the stratum corneum bringing the vaccine in contact with cutaneous APCs [132].…”

Laser-engineered dissolving microneedle arrays for protein delivery: potential for enhanced intradermal vaccination

“…Dissolving MN arrays have been shown to enhance transdermal and intradermal delivery of numerous substances, including insulin,[2,3] 5‐aminolevulinic acid,[4] sulforhodamine B,[5] low molecular weight heparin,[6] ovalbumin (OVA),[7,8] adenovirus vector[8] and a variety of vaccine antigens [9–12]…”

Improvement of Transdermal Delivery of Sumatriptan Succinate Using a Novel Self-dissolving Microneedle Array Fabricated from Sodium Hyaluronate in Rats

“…Compared with the earlier studies, our present study employed high density SS-loaded MNs (500 needles/array). 25) Moreover, the present study paid more attention to the evaluation of the moisture absorption speed of our MNs at a high wet environment, and then mechanical strength of the moisture-conditioned MNs was accordingly measured to obtain a specific needle soften trend, providing an useful reference for the practical application. It was found that the MNs maintained their skin piercing capability for up to 30 min after being placed at a high relative humidity of 75%.…”

“…These results were well consistent with the research of Hiraishi et al, who demonstrated that the model antigen fluorescein isothiocyanate-labeled-ovalbumin (FITC-OVA) was gradually delivered from the epidermis to superficial dermis after applying the FITC-OVA-loaded self dissolving MNs to the mice skin. 25) Further, following the dissolution of MNs, the drug permeation pathways created by insertion of MNs gradually resealed over time because of the elastic nature of skin.…”

“…The following groups of animals were studied before and after drug administration. 24) (1) SS intravenous (i.v.) group, where SS solution (5.0 mg/kg in PBS, pH 7.4) was injected intravenously into the jugular vein using a hypodermic needle; (2) SS s.c. group, where SS solution (5.0 mg/kg) was injected subcutaneously into abdominal skin; (3) SS oral group, where SS solution (5.0 mg/kg) was administered orally using an intragastric needle; (4) MNs+SS solution group, where placebo MNs were applied onto abdominal skin and removed 5 min later, then a piece of cotton (diameter 10 mm) saturated with SS solution (5.0 mg/kg) was applied onto the treated skin site; (5) SS-loaded MNs group, where MNs containing three different amounts of SS (2.4, 5.0, and 9.6 mg/kg) were prepared and applied to abdominal skin, then fixed with gum tape.…”