This study aims to utilize pyrolysis oil produced from the pyrolysis of waste polyethylene in a direct injection (DI) diesel engine. In this paper, the performance and emission of a diesel engine have been studied using blends of waste polyethylene pyrolysis oil with diesel fuel under different loads condition. The waste polyethylene pyrolysis oil (WPO) used in this work was produced from the sequential pyrolysis and catalytic reforming of polyethylene bag after crushing and washing using natural zeolite (NZ) catalyst. Engine tests have been done using a four-cylinder and four-stroke diesel engine with the compression ratio of 22 and water cooling system. The experimental works were done at the rated engine speed of 1800 rpm. The results indicated that the brake thermal efficiencies are slightly higher as compared to that of diesel while the brake specific fuel consumption (BSFC) is slightly reduced when blending diesel fuel with WPO. Moreover, WPO-diesel fuel blends at various engine loads are also found to have influences on the emissions of CO, HC, NOx, and the smoke opacity. The NOx emission is found to be lowered by blending diesel with WPO. The decreased NOx emission is due to the decrease of the in-cylinder temperature by the effect of the non-homogeneity of WPO. The emissions of HC and CO of WPO-diesel blends are higher than that of diesel. Finally, the smoke opacity for WPO blends is slightly higher at higher loads.