Fuel additives from waste have been suggested to enhance low octane commercial gasoline in this study. Four samples were prepared in addition to pure commercial gasoline and denoted as GF0, GF4, GF8, GF12, and GF 16 which refer to fusel oil addition ratio of 0%, 4%, 8%, 12, and 16% respectively. Engine speed was controlled and increased manually from 1000 rpm to 3000 rpm at an increment of 500 rpm. Design of experiments is used to indicate the optimum additive dosage through response surface method optimization. Obtained results show that increasing engine speed significantly impacts the engine brake power, brake-specific fuel consumption, and brake thermal efficiency with a slight change for fusel oil ratio. Accordingly, it can be concluded that the maximum increase in output variables is statistically linked with the engine speed. The output response values at optimized conditions were 2.61812 kW brake power, 0.2431 kg/kW.hr brake-specific fuel consumption, and 36.5303% brake thermal efficiency. Based on the P-value, ANOVA data indicate that engine speed was a significant factor influencing output responses, while the fusel oil ratio was insignificant. However, fusel oil ratio of 8% has a significant effect on the brake thermal efficiency and BSFC.