Performance Characteristics of Body Fluid Cytology Analysis of 344 380 Responses From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology

Tabatabai, Z. Laura; Nayar, Ritu; Souers, Rhona J.; Crothers, Barbara A.; Davey, Diane D.

doi:10.5858/arpa.2016-0509-cp

Cited by 11 publications

(5 citation statements)

References 10 publications

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“…Hence, it is imperative that the cytopathologist should be able to recognize the malignant cells accurately, identify the tumor type and if possible, suggest the primary site of origin of the tumor 1 . It is generally agreed that detection of malignant cells is much more difficult and challenging in effusions and body fluids than in other cytologic samples 2,3 . Sometimes it may be difficult to obtain a diagnosis on the basis of cytomorphology alone.…”

Section: Introductionmentioning

confidence: 99%

“…Although effusions can occur any time during the course of lymphoreticular malignancies (LRMs); involvement of effusions by lymphoreticular malignancies per se is relatively rare, with the reported incidence ranging from 3% to 30% among different studies in the literature 2‐6 . The literature on cytomorphological features of LRMs in effusion fluids is sparse.…”

Section: Introductionmentioning

confidence: 99%

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Lymphoreticular malignancies in serous effusions: Cytomorphologic, flow cytometric and immunocytochemical analysis

Gupta

Pandey

Gautam

et al. 2021

Diagnostic Cytopathology

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Introduction Involvement of body fluids by lymphoreticular malignancies (LRM) is rare and often associated with poor prognosis and decreased overall survival. The present study was conducted to analyze the characteristic cytomorphologic, flow cytometric and immunocytochemical features of LRMs in serous effusions. Materials and methods This was a three‐year retrospective study. A total of 218 effusion samples, reported as involved by lymphoreticular malignancies, on cytology, were reviewed. All the cases wherein the cytological diagnosis was confirmed by flow cytometric (FCM) and/or immunocytochemical (ICC) studies were retrieved and studied in detail. FCM and/or ICC were performed in a total of 51/218(23.4%) samples, including 30 pleural (58.8%), 18 peritoneal (35.3%), and 3 pericardial fluid (5.9%) samples. Results The cytomorphologic diagnoses included infiltration by non‐Hodgkin lymphoma (NHL;n = 27), infiltration by LRM (n = 19), infiltration by chronic lymphocytic leukemia (CLL;n = 2), Hodgkin's lymphoma (HL;n = 1) and suggestive of infiltration by LRM (n = 2). FCM and/or ICC confirmed the diagnoses as infiltration by T‐cell lymphoblastic lymphoma in 18; mature B‐cell NHL in 10; Burkitt lymphoma in 7; diffuse large B‐cell lymphoma in 4; follicular lymphoma, T‐ cell NHL and CLL in 2 samples each and hairy cell leukemia, plasmablastic lymphoma and HL in 1 sample each. 94.1% concordance was noted between the initial and final cytologic diagnosis. Conclusions Involvement of body fluids and effusions by LRMs, though rare, carries an immense prognostic significance and hence the prompt detection is crucial. Detection of these malignancies by cytologic examination of effusions is challenging yet potentially useful and the least invasive method available to establish an early diagnosis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lymphoreticular malignancies in serous effusions: Cytomorphologic, flow cytometric and immunocytochemical analysis

Gupta

Pandey

Gautam

et al. 2021

Diagnostic Cytopathology

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“…Effusions can be caused by inflammatory, infectious, and benign; neoplastic or malignant; and primary or metastatic diseases. Such conditions in effusions may often have overlapping features and mimic one another both cytomorphologically and clinically, presenting diagnostic challenges [1].…”

Section: Introductionmentioning

confidence: 99%

Cytological study of body fluids for malignancy

Saba

Prakash

P.S

et al. 2019

Trop J Pathol Microbiol

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“…Penelitian ini sejalan dengan teori berikut yang menyatakan bahwa efusi pleura dapat terjadi pada pasien dengan karsinoma paru dari semua jenis histologi, namun lebih sering terjadi pada jenis adenokarsinoma (40% dari semua kasus efusi pleura). 7 Adenokarsinoma sebenarnya jenis histologi yang paling umum dari kelompok karsinoma bukan sel kecil, yaitu sekelompok sel dengan kecenderungan membentuk kelompok kohesif berkontur halus yang terdiri dari sel-sel besar dengan inti yang eksentrik, tampak ganas, nucleolus menonjol dan sitoplasma bervakuol 16 , jenis histology ini lebih sering tumbuh pada bagian perifer paru sehingga memudahkan untuk menyerang pleura. 17 Hal ini sesuai dengan hasil penelitian Ariyansyah, dkk dengan hasil dominan berupa adenokarsinoma.…”

Section: Pembahasanunclassified

Profil Sitologi Efusi Pleura di RSUD Zainoel Abidin Banda Aceh

Ismida

Yanti²,

Husna³

et al. 2021

JKS

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Efusi pleura merupakan problem diagnosticutama pada kelainanparukarena pleura merupakansuaturongga yang melapisiparutanpaadaaksesapapun. Analisissitologiefusi pleura seringkalidigunakansebagailinipertamapenapisandalampenegakan diagnosis dan tindakanpenatalaksananlebihlanjut. Pemeriksaansitologiefusi pleura sangatpentingkarenadapatmemberikaninformasiinflamasi, keganasan dan metastasis.Penelitianinimenggunakanmetodedeskriptif, mengamatiseluruhbahanefusi pleura yang dilakukananalisissitologiselamaperiodeduatahun dan diperoleh 697 kasusefusi pleura di laboratoriumPatologiAnatomiRumahSakitZainoelAbidin, Banda Aceh. Hasil pemeriksaansitologi 697 bahanefusi pleura ditemukan paling banyakmenunjukkan diagnosis klinistidakdapatdisimpulkan 344 efusi pleura dan diagnosis klinisbukansuatu proses keganasan 294 (total 91,52%), diantaranya paling banyakmenunjukkansuatuperadangankronisdengansebaransellimfosit yang dominanyaitu 124 (41.5%). Dan dari 59 bahanefusi pleura denganjeniskeganasanmenunjukkanbahwa paling banyakditemukan adenocarsinomayaitu 29 (49,1%) dan terdapat 22 (37,3%) bahanefusi pleura denganjeniskeganasan primer yaituSquamousCellCarsinoma. Sitologiefusi pleura merupakanmodalitasdiagnosticmudah dan sederhana yang sangatmembantudalammenegakkan diagnosis efusi pleura dan berperandalammelakukaneksplorasietiologi dan prognosis penyakit. Oleh karenaitu, semuakelainanefusi pleura yang belumterdiagnosissebaiknyadilakukanpemeriksaansitologiuntuk diagnosis awal dan manajemenpasienselanjutnya.

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Performance Characteristics of Body Fluid Cytology Analysis of 344 380 Responses From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology

Abstract: - This study illustrates the challenges associated with interpreting body fluid cytology, particularly in pericardial fluid, and the factors that may affect accurate diagnoses. The results also highlight the value of using multiple preparation types in challenging cases.

Cited by 11 publications

References 10 publications

Lymphoreticular malignancies in serous effusions: Cytomorphologic, flow cytometric and immunocytochemical analysis

Lymphoreticular malignancies in serous effusions: Cytomorphologic, flow cytometric and immunocytochemical analysis

Cytological study of body fluids for malignancy

Profil Sitologi Efusi Pleura di RSUD Zainoel Abidin Banda Aceh

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