During military training and operations, exposure to extremes of noise, temperature, humidity, pressure, or acceleration can induce levels of physiological strain that degrade cognitive and physical capabilities, threaten health and safety, and affect behavior and performance. The overarching purpose of this chapter is to discuss the impact of environmental stress on military personnel. Because each of the aforementioned stressors induces disparate effects, each section addresses a unique stressor in terms of (i) the nature of the threat, (ii) physiological and biomedical effects, (iii) the impact on performance, and (iv) management strategies. The evolution of next-generation wearable biosensors, smart performance algorithms, and scientifically based operational training methods including stress inoculation exposure that will contribute to improved training, adaptation, and tolerance to these operational stresses is discussed.